High Sensitivity of Gastric Mucosa to Ulcerogenic Effect of Indomethacin in Rats with Diabetes

Abstract

One week after injection of streptozotocin (60 mg/kg intravenously), rats developed diabetes associated with a significant increase of gastric mucosa sensitivity to the ulcerogenic effect of indomethacin (35 mg/kg subcutaneously). Since potentiation of the ulcerogenic effect of indomethacin was observed only in rats subjected to fasting before drug injection, we hypothesize that this effect was caused by a drop of high glucose level in the blood after fasting.

Diabetes is an independent risk factor for peptic ulcer bleeding: A nationwide population‐based cohort study

“…13 Animal studies show that diabetes increases susceptibility to acute gastric injury and impaired ulcer healing. [5][6][7]14 Diabetic patients are likewise inclined to have complicated PUD like PUB probably because they initially more asymptomatic or they have equivocal symptoms because of diabetic autonomic neuropathy. 4,15 In general, NSAID/aspirin usage, Helicobacter pylori infection, history of ulcer/ulcer bleeding, cirrhosis, and chronic renal disease are all important risk factors for PUB.…”

“…When these defensive and healing factors are less than the aggressive factors, mucosal injuries worsen, and ulcers develop . Animal studies show that diabetes increases susceptibility to acute gastric injury and impaired ulcer healing . Diabetic patients are likewise inclined to have complicated PUD like PUB probably because they initially more asymptomatic or they have equivocal symptoms because of diabetic autonomic neuropathy …”

“…4 Animal studies show delayed gastric ulcer healing and aggravated gastric mucosal susceptibility to ulcerogenic drugs or stress in diabetic rats. [5][6][7] Whether diabetes mellitus increases the risk of PUB still needs to be evaluated. This nationwide population-based study aimed to investigate the association between type II diabetes and PUB after adjusting for potential confounding factors like ulcerogenic medication and underlying comorbidity, and to identity independent risk factors for PUB in type II diabetic patients.…”

“…Diabetic patients have been found to have a higher incidence of peptic ulcer disease (PUD) than the non‐diabetic population . Animal studies show delayed gastric ulcer healing and aggravated gastric mucosal susceptibility to ulcerogenic drugs or stress in diabetic rats …”