PACS numbers:Recent experimental progress in table-top experiments [1,2] or gravitational-wave interferometers [3] has enlightened the unique displacement sensitivity offered by optical interferometry. As the mirrors move in response to radiation pressure, higher power operation, though crucial for further sensitivity enhancement, will however increase quantum effects of radiation pressure, or even jeopardize the stable operation of the detuned cavities proposed for next-generation interferometers [4,5,6]. The appearance of such optomechanical instabilities [7,8] is the result of the nonlinear interplay between the motion of the mirrors and the optical field dynamics. In a detuned cavity indeed, the displacements of the mirror are coupled to intensity fluctuations, which modifies the effective dynamics of the mirror. Such "optical spring" effects have already been demonstrated on the mechanical damping of an electromagnetic waveguide with a moving wall [9], on the resonance frequency of a specially designed flexure oscillator [10], and through the optomechanical instability of a silica micro-toroidal resonator [11]. We present here an experiment where a micro-mechanical resonator is used as a mirror in a very high-finesse optical cavity and its displacements monitored with an unprecedented sensitivity. By detuning the cavity, we have observed a drastic cooling of the microresonator by intracavity radiation pressure, down to an effective temperature of 10 K. We have also obtained an efficient heating for an opposite detuning, up to the observation of a radiation-pressure induced instability of the resonator. Further experimental progress and cryogenic operation may lead to the experimental observation of the quantum ground state of a mechanical resonator [12,13,14], either by passive [15] or active cooling techniques [16,17,18].The resonator is placed at the end of a linear cavity, along with a conventional coupling mirror (Fig. 1a). As we are only interested in the motion at frequencies Ω close to a resonance frequency Ω m of the resonator, the mirror dynamics can be approximated as the one of a single harmonic oscillator, with resonance frequency Ω m , mass M , damping Γ m and mechanical susceptibility:The resonator is submitted to a radiation pressure force F rad induced by the intracavity field. Depending on the detuning Ψ ≡ 4πL/λ [2π], where L is the cavity length and λ the laser wavelength, any small displacement x of the resonator induces a variation of the intracavity power P and of the radiation pressure (see Fig. 1b). As a consequence, the spring constant k = M Ω 2 m of the resonator is balanced by the radiation pressure force: for a positive detuning, the displacement creates a negative linear force and thereby an additional binding force, increasing the effective spring constant, whereas for a negative detuning, the force corresponds to a softening of the oscillator. Effects are null at resonance, maximum at half-width of the optical resonance, and proportional to the incident power. These effects hav...