High‑sensitivity troponin T as a prognostic marker in patients undergoing aortic valve replacement

Abstract

using EuroSCORE II. On the day before surgery, blood samples for the measurement of biomarker levels were collected from each patient. Complete blood count was performed with K 2 -EDTA samples, using a Cobas 6000 electronic counter (Roche, Mannheim, Germany). The plasma levels of cardiac TnT (cTnT) concentrations were measured by the Troponin T hs -STAT (Roche). The endpoint was all-cause death. Patients were followed by direct observation during hospitalization, telephone interviews, or clinic visits for 30 days after the surgery or until death. The study protocol was approved by an institutional review board.Statistical analysis A statistical analysis was performed using SAS version 9.2 (World Headquarters SAS Institute, Cary, North Carolina, United States). Logistic regression was used to assess relationships between variables. The following covariates were investigated for association with the endpoint in a univariate analysis: age, atrial fibrillation, body mass index, chronic obstructive pulmonary disease, CAD, current smoking, EuroSCORE II, hyperlipidemia, hypertension, insulin -dependent diabetes mellitus, left ventricular ejection fraction, New York Heart Association class, peripheral atherosclerosis, previous myocardial infarction, pulmonary blood pressure, history of stroke, tricuspid annulus plane systolic excursion, the levels of bilirubin, creatinine, high -sensitivity C -reactive protein, hs -TnT, hematocrit, hemoglobin, mean corpuscular hemoglobin, and N -terminal pro -B-type natriuretic peptide, glomerular filtration rate, mean corpuscular volume, and platelet and white blood cell counts.

The usefulness of selected biomarkers in aortic regurgitation

“…The predictive power of the preoperative TnT for death in 30-days follow-up in a group of 224 patients with surgically treated severe aortic stenosis was previously demonstrated [9]. Moreover, in a small group of 60 patients with severe aortic valve stenosis undergoing aortic surgery, preoperative TnT was an important predictor of serious post-operative complications in long-term follow-up [21].…”

“…Moreover TnT is a recognized biomarker of myocardial injury [1]. In the available literature, several studies have reported that elevated high-sensitivity TnT (hs-TnT) is associated with poor outcomes in patients with stable coronary heart disease, acute myocardial infarction (MI), heart failure (HF), dilated cardiomyopathy, atrial fibrillation or significant aortic stenosis [2][3][4][5][6][7][8][9].…”

Postoperative high-sensitivity troponin T as a predictor of sudden cardiac arrest in patients undergoing cardiac surgery

“…Therefore, TnT detected in plasma is a highly specific marker of myocardial injury [14][15][16]. To date, numerous publications have demonstrated a significant relationship between higher troponin values and worse prognosis in patients with acute myocardial infarction, heart failure or severe aortic valve disease [9][10][11][12][13]. It has also been described that TnT is a predictor of cardiac death in patients with CAD, atrial fibrillation or impaired left ventricular function [17][18][19][20][21].…”

“…Thanks to this, after obtaining specific monoclonal antibodies, it became possible to use them in the diagnosis of ischemia and hypoxia of cardiomyocytes [8]. In the available literature, numerous articles describe high sensitivity troponin T (hs-TnT) as a biomarker of predictive importance in various diseases of the cardiovascular system, such as heart failure, coronary artery disease (CAD) and aortic stenosis [9][10][11][12][13]. The usefulness of the hs-TnT as a predictor of perioperative SCA in patients with valve disease undergoing valve surgery is currently unknown.…”

High-sensitivity C-reactive protein as a prognostic marker in patients undergoing valve surgery

“…The results of the present study indicate that the ongoing inflammatory process is associated with worse work of individual organs and systems, as indicated by the significant correlation demonstrated between CRP and haemoglobin, RDW, LVEF, TnT, creatinine and BMI parameters, which may have a decisive effect on the cardiosurgical treatment. And although fairly good calibration and discrimination of the EuroSCORE II calculator have been confirmed in the group of Polish patients undergoing cardiac surgery, information about the predictive ability of the CRP parameter may be useful for doctors both during the process of qualifying patients for cardiac surgery and in the postoperative period during patient care in intensive care unit therapy [2,22,23].…”