High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden

Johansson, Helena; Odén, Anders; Lerner, Ulf H.; Jutberger, Hans; Lorentzon, Mattias; Barrett‐Connor, Elizabeth; Karlsson, Magnus K.; Ljunggren, Östen; Smith, Ulf; McCloskey, Eugène; Kanis, John А.; Ohlsson, Claes; Mellström, Dan

doi:10.1002/jbmr.1591

Cited by 53 publications

(52 citation statements)

References 36 publications

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“…Nevertheless, most association studies showed negative correlations between BMD and adiponectin in premenopausal and postmenopausal women and in men (30,34,35). In the Osteoporotic Fractures in Men study, the risk of fracture increased in parallel with increasing serum adiponectin (36). Although adiponectin levels were low in obese and diabetic patients (37), in our study it increased with increasing fat mass in men and mediated for the negative effect of fat on BMD as well.…”

Section: Discussionmentioning

confidence: 57%

Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults

Aguirre

Napoli

Waters

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 57%

Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults

Aguirre

Napoli

Waters

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Several studies have suggested that higher levels of serum adiponectin are associated with incident fractures in elderly men [22], [23]. Barbour and colleagues [24] found a significant association between serum adiponectin and all fractures in men but not in women.…”

Section: Discussionmentioning

confidence: 99%

The Association between Aortic Calcification and Fracture Risk in Postmenopausal Women in China: The Prospective Chongqing Osteoporosis Study

Zhou

Cui

et al. 2014

PLoS ONE

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PurposeFractures are associated with cardiovascular diseases in the elderly. The purpose of the present study was to investigate the association between aortic calcification (AC) and the risk of vertebral fractures in postmenopausal Chinese women.MethodsA prospective study with 5 years of follow-up in 1724 postmenopausal women (aged 50 years old and older) was conducted from July 2005 to June 2010. Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density (BMD). Aortic calcification score (ACS) was determined by a semi-quantitative method and was further categorized into four groups. Cox proportional hazards models were established to assess the association between AC and the risk of vertebral fractures.ResultsFor subjects with AC, the incidence of vertebral fractures was higher than that of those without AC (p<0.01). After adjustment for age and other potential confounders, it was found that severe AC (G4, ACS>6; G3, ACS = 3–6) was associated with vertebral fractures. Severe AC (G4) was associated with non-vertebral fractures. There were higher risk for the vertebral fractures in two groups and higher risk for non-vertebral fractures in one group.ConclusionsThe results of the current study indicate that severe AC is associated with a significantly increased risk of vertebral fractures and non-vertebral fractures in postmenopausal women in China.

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“…In animal models, depletion of adiponectin has been shown to protect mice from ovariectomy-induced osteoporosis (30). Finally, a high adiponectin level has been shown to be associated with incident fractures in elderly males (31). In the present study, high plasma adiponectin levels were identified in patients with LDD.…”

Section: Discussionmentioning

confidence: 99%

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

Khabour

Abu-Rumeh

Al-Jarrah

et al. 2014

Experimental and Therapeutic Medicine

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Lumbar disc degeneration (LDD) is a widespread public health problem that may lead to disability and loss of productivity. Adiponectin is an adipokine secreted by adipose tissue and has been shown to be involved in cartilage homeostasis. In the present study, the association between the rs266729 (−11377C/G) and rs2241766 (45T/G) single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and LDD was investigated. In addition, the correlation between the plasma adiponectin level and LDD was examined. A total of 289 subjects, 168 patients with LDD and 122 healthy individuals, were recruited in the study. All subjects were genotyped for rs266729 and rs2241766 SNPs using polymerase chain reaction-restriction fragment length polymorphism. Circulating levels of adiponectin protein were measured using the ELISA technique. A strong association was found between adiponectin level and LDD (P<0.01), where high levels of adiponectin were found in patients compared with healthy controls. The increase in adiponectin level was not affected by gender. However, no significant differences were found in the genotype distribution or allelic frequency of the two examined polymorphisms between patients with LDD and healthy controls (P>0.05). In conclusion, adiponectin appears to be elevated in patients with LDD. The rs266729 and rs2241766 SNPs in the ADIPOQ gene are not associated with LDD.

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High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden

Cited by 53 publications

References 36 publications

Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults

Increasing Adiposity Is Associated With Higher Adipokine Levels and Lower Bone Mineral Density in Obese Older Adults

The Association between Aortic Calcification and Fracture Risk in Postmenopausal Women in China: The Prospective Chongqing Osteoporosis Study

Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration

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