High serum and urine neutrophil gelatinaseassociated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy

Rhee, Harin; Shin, Nari; Shin, Min Ji; Yang, Byung Yun; Kim, Il Young; Song, Sang Heon; Lee, Jun Young; Lee, Soo Bong; Kwak, Ihm Soo; Seong, Eun Young

doi:10.3904/kjim.2015.30.3.354

Cited by 15 publications

(9 citation statements)

References 27 publications

(42 reference statements)

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“…However, none of these markers are sensitive or specific; thus, predicting the risk of disease progression remains controversial. Several studies have described new kidney biomarkers that might predict renal outcome independently, such as kidney injury molecule-1, neutrophil gelatinase–associated lipocalin, and nestin, but these markers should be validated more thoroughly [5] , [6] , [7] .…”

Section: Introductionmentioning

confidence: 99%

Plasma endocan level and prognosis of immunoglobulin A nephropathy

Lee

Kim

et al. 2016

Kidney Research and Clinical Practice

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BackgroundEndocan, previously called endothelial cell–specific molecule-1, is a soluble proteoglycan that is secreted from vascular endothelial cells. Elevated plasma endocan levels were shown to be associated with poor cardiovascular outcomes in patients with chronic kidney disease (CKD). We investigated the clinical relevance of plasma and urine endocan levels in patients with immunoglobulin A nephropathy (IgAN).MethodsSixty-four patients with IgAN and 20 healthy controls were enrolled in this study. Plasma and urine endocan levels were measured. Clinical parameters, pathologic grades, and renal outcomes were compared among subgroups with different plasma and urine endocan levels.ResultsBoth plasma and urine endocan levels were significantly higher in patients with IgAN than in controls. Elevated serum phosphorus and C-reactive protein were independent determinants for plasma endocan, and elevated C-reactive protein was also an independent determinant for urine endocan levels in multivariate analysis. Plasma endocan level was not significantly different across CKD stages, but patients with higher plasma endocan levels showed adverse renal outcome. Urine endocan levels were also elevated in patients with poor renal function. Cox proportional hazard models showed that high plasma endocan was an independent risk factor for CKD progression after adjusting for the well-known predictors of outcome in patients with IgAN.ConclusionThis study suggested that plasma endocan might be useful as a prognostic factor in patients with IgAN.

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Section: Introductionmentioning

confidence: 99%

Plasma endocan level and prognosis of immunoglobulin A nephropathy

Lee

Kim

et al. 2016

Kidney Research and Clinical Practice

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“…Полученные нами данные об ассоциации гломерулосклероза, атрофии канальцевого эпителия и экскреции NGAL с мочой позволяют предполагать, что нарушение реабсорбции NGAL в эпителиоцитах проксимальных канальцев, обусловленное ишемией данного отдела нефрона из-за прогрессирующего гломерулосклероза, играет ключевую роль в увеличении экскреции данного пептида с мочой. В пользу данного обстоятельства говорят также и результаты экспериментальных работ, свидетельствующие о снижении продукции мРНК NGAL в почках по мере формирования фиброза тубулоинтерстиция и атрофии эпителиоцитов [29].…”

Section: рис 1 Roc-кривые с 95% доверительным интервалом (пунктирные линии) для различных биомаркеров относительно морфологических изменеunclassified

Diagnostic value of urinary biomarkers excretion in estimation of morphological lesions in patients with primary glomerulopathies

Saganova

Zubina

Bogdanova

et al. 2021

Terapevticheskii arkhiv

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Aim. To investigate the diagnostic value of biomarkers in assessing the severity of sclerotic and atrophic lesions in primary glomerulopathies. Materials and methods. One hundred patients were included in the study, according to the results of kidney biopsy in 9 (9%) cases minimal change disease was diagnosed, in 28 (28%) focal segmental glomerulosclerosis, in 26 (26%) membranous nephropathy and in 37 (37%) IgA nephropathy. The clinical course of nephropathy was evaluated, standard laboratory tests were performed, and urinary excretions of cystatin C, 1-microglobulin, 2-microglobulin and NGAL were measured. The degree of glomerulosclerosis was assessed quantitatively, tubulointerstitial sclerosis and tubular atrophy semiquantitatively. Results. According to the results of linear correlations and ROC-analysis, urinary excretion of cystatin C and 1-microglobulin had diagnostic value for early degree of tubulointerstitial sclerosis (cut-off value 319.9 and 10.94 mg/day, respectively). Urinary excretion of 2-microglobulin reflected the initial degree of tubalar atrophy (cut-off value of 0.224 mcg/day), as well as tubulointerstitial sclerosis of various degrees of severity (cut-off value 0.224 and 0.240 mkg/day). NGAL urinary excretion was the only marker of early degree of glomerulosclerosis with its excretion of more than 1445.4 ng/day and tubular atrophy, with a severity of 50% or more (cut-off value 4897.8 ng/day). Conclusion. A comprehensive assessment of sclerotic and atrophic lesions in the renal parenchyma, can be performed using a panel of traditional (GFR, proteinuria) and specific biomarkers (1-, 2-microglobulins, cystatin C, NGAL) to implement a comprehensive, personalized approach, as well as to assess the prognosis of nephropathy. In addition, the evaluation of the panel of different biomarkers can be used in those clinical situations where kidney biopsy can not be performed.

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“…On the other hand, urine levels of NGAL can be increased in conditions other than AKI such as is the case with serum NGAL. Urine NGAL is for instance increased in immunoglobulin A nephropathy (IgAN) [ 21 ]. Moreover, urinary NGAL seems to be increased also in acute urinary tract infections [ 22 ].…”

Section: Novel Biomarkersmentioning

confidence: 99%

Novel biomarkers for early diagnosis of acute kidney injury after cardiac surgery in adults

Gavrić

Kališnik

2016

kitp

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Acute kidney injury after cardiac surgery with cardiopulmonary bypass is a common and serious complication and it is associated with increased morbidity and mortality. Diagnosis of acute kidney injury is based on the serum creatinine levels which rise several hours to days after the initial injury. Thus, novel biomarkers that will enable faster diagnosis are needed in clinical practice. There are numerous urine and serum proteins that indicate kidney injury and are under extensive research. Despite promising basic research results and assembled data, which indicate superiority of some biomarkers to creatinine, we are still awaiting clinical application.

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High serum and urine neutrophil gelatinaseassociated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy

Cited by 15 publications

References 27 publications

Plasma endocan level and prognosis of immunoglobulin A nephropathy

Plasma endocan level and prognosis of immunoglobulin A nephropathy

Diagnostic value of urinary biomarkers excretion in estimation of morphological lesions in patients with primary glomerulopathies

Novel biomarkers for early diagnosis of acute kidney injury after cardiac surgery in adults

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