High serum anti-BP180 IgE levels correlate to prominent urticarial lesions in patients with bullous pemphigoid

Cho, Yung-Tsu; Liao, Shu-Ling; Wang, Li-Fang; Chu, Chia-Yu

doi:10.1016/j.jdermsci.2016.03.009

Cited by 15 publications

(16 citation statements)

References 10 publications

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“…As shown in Table 2 , nine studies [ 7 , 11 , 18 , 26 , 32 , 34 , 39 , 40 , 57 ] found that anti-BP180 autoantibodies of IgE class are associated with increased severity of BP, in contrast to two studies [ 38 , 42 ] which did not find such an association. The two studies which reported no association did not seem to have any major differences in conduct from the rest of the studies which did report an association.…”

Section: Resultsmentioning

confidence: 99%

“…Since it has been demonstrated that total serum IgE levels correlate directly with the levels of IgE specific for BP180 and BP230 antigens [ 35 ] and that there is a good positive correlation between circulating IgE autoantibodies and total serum IgE [ 25 ], some studies have sought to determine whether disease severity correlates with total serum IgE levels: three studies reported a positive correlation between total serum IgE levels [ 11 , 34 , 35 ] and disease severity and one study [ 14 ] reported no correlation.…”

Section: Resultsmentioning

confidence: 99%

“…Table 3 shows the numbers of studies that have reported correlation (or lack of correlation) of various IgE parameters to the different phenotypes of BP [ 11 , 14 , 26 , 42 , 57 , 59 ]. Overall, these studies indicate that IgE autoantibodies are not specifically associated with the blisters and eruptions seen in the typical presentation of BP.…”

Section: Resultsmentioning

confidence: 99%

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IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review

et al. 2017

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Bullous pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP. Our objective was to determine whether there is strong evidence for an association between IgE class autoantibodies and the clinical severity or phenotype of BP. Three databases were searched for relevant studies and appropriate exclusion and inclusion criteria were applied. Data was extracted and assessed in relation to the study questions concerning the clinical significance of IgE autoantibodies in BP. Nine studies found that anti-BP180 autoantibodies of IgE class are associated with increased severity of BP, whereas two studies did not find such an association. The number of studies which found an association between higher IgE autoantibody levels and the erythematous urticarial phenotype of BP (5) was equal in number to the studies which found no such association (5). In conclusion, higher serum IgE autoantibody levels are associated with more severe clinical manifestations of BP. There is insufficient evidence to support higher IgE autoantibody levels being associated with specific clinical phenotypes of BP.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review

et al. 2017

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“…That is, the higher the serum levels of IgE autoantibodies against BP180, the greater are the number of urticarial lesions and infiltrating eosinophils. Hence, the level of IgE autoantibodies against BP180 correlates closely with the total score of BPDAI [9,45]. However, van Beek et al discovered that the anti-BP180NC16A antibodies were associated with the occurrence of erosions and blisters, but not urticarial and erythematous lesions [46].…”

Section: Both-related Factorsmentioning

confidence: 99%

Factors associated with the activity and severity of bullous pemphigoid: a review

et al. 2020

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Bullous pemphigoid (BP) is the most common subepidermal autoimmune blistering disease. It usually affects people older than 70 years of age. The two main autoantigens are BP180 and BP230, both of which are components of hemidesmosomes. Immunoglobulin (Ig)G and IgE autoantibodies to BP180 detected by the enzyme-linked immunoassay (ELISA) show close associations with the activity and severity of BP. In addition, inflammatory cells (eosinophils, neutrophils and mast cells) and cytokines (e.g. interleukins and CC chemokine ligands) play an important part in the pathogenesis, activity and severity of BP. We summarized the potential contribution of each factor postulated to be associated with the activity and severity of BP, and provide guidance for clinicians to pay timely and close attention to such parameters. This review may also promote the development of novel therapies for BP. KEY MESSAGES Bullous Pemphigoid Disease Area Index (BPDAI) is a scoring system which can reflect the extent of clinical involvement of BP patients. The titres of IgE autoantibodies and IgG autoantibodies against the NC16A domain of BP180 are closely correlated with the activity and severity of BP. Many inflammatory cells and molecules, such as eosinophils and interleukins, can also reflect the activity and severity of BP.

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“…In addition to the IgG autoantibodies, 22–100% BP patients also produce IgE autoantibodies against BP180 NC16A ( 24 , 46 , 96 , 97 ). The level of anti-NC16A IgE is correlated with disease activity ( 24 , 46 ), occurrence of urticarial lesions and erythema ( 46 , 98 , 99 ), higher prednisolone dosage, longer duration before remission, and more intensive therapies ( 100 ). Immunofluorescence revealed the deposition of IgE autoantibodies along the DEJ in up to 41% of BP patients ( 101 ).…”

Section: Autoantibodies Targeting Nc16a Of Bp180mentioning

confidence: 99%

BP180 Is Critical in the Autoimmunity of Bullous Pemphigoid

Liu

Xia

2017

Front. Immunol.

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Bullous pemphigoid (BP) is by far the most common autoimmune blistering dermatosis that mainly occurs in the elderly. The BP180 is a transmembrane glycoprotein, which is highly immunodominant in BP. The structure and location of BP180 indicate that it is a significant autoantigen and plays a key role in blister formation. Autoantibodies from BP patients react with BP180, which leads to its degradation and this has been regarded as the central event in BP pathogenesis. The consequent blister formation involves the activation of complement-dependent or -independent signals, as well as inflammatory pathways induced by BP180/anti-BP180 autoantibody interaction. As a multi-epitope molecule, BP180 can cause dermal–epidermal separation via combining each epitope with specific immunoglobulin, which also facilitates blister formation. In addition, some inflammatory factors can directly deplete BP180, thereby leading to fragility of the dermal–epidermal junction and blister formation. This review summarizes recent investigations on the role of BP180 in BP pathogenesis to determine the potential targets for the treatment of patients with BP.

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High serum anti-BP180 IgE levels correlate to prominent urticarial lesions in patients with bullous pemphigoid

Cited by 15 publications

References 10 publications

IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review

IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review

Factors associated with the activity and severity of bullous pemphigoid: a review

BP180 Is Critical in the Autoimmunity of Bullous Pemphigoid

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