High serum bilirubin is associated with lower prevalence of peripheral arterial disease among cardiac patients

Ozeki, Michishige; Morita, Hideaki; Miyamura, Masatoshi; Fujisaka, Tomohiro; Fujita, Shuichi; Ito, Takahide; Shibata, Kensaku; Tanaka, Suguru; Sohmiya, Koichi; Hoshiga, Masaaki; Ishizaka, Nobukazu

doi:10.1016/j.cca.2017.11.013

Cited by 22 publications

(26 citation statements)

References 49 publications

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“…Chinese hypertensive males subjects, the mean age of our study participants was 63.86 ± 9.25 years, the median serum concentrations of TBiL was14.10 µmol/L (interquartile range 11.00 to 18.60 µmol/L); However, Ozeki et al's study (17) (8). Because the effect of these covariates on PAD is too signi cant to cover up the effect of serum bilirubin on PAD, the independent effect of serum bilirubin on PAD is only re ected after adjusting it.…”

Section: Discussionmentioning

confidence: 56%

“…Several previous studies had examined the relationships between TBiL levels and PAD (17)(18)(19). Ozeki et al (17) , and this association is more in uential in men compared with women (19). However, these studies did not discuss a nonlinear relationship between TBiL and PAD.…”

Section: Discussionmentioning

confidence: 99%

“…Bilirubin is a potent antioxidant under physiological conditions; a higher TBiL level could be a protector factor for atherosclerosis (13). At the same time, some studies have shown that elevated TBiL levels were negatively correlated with coronary artery disease (CAD) (14)(15)(16), arterial stiffness (12), and PAD (17)(18)(19). Excessive TBiL is probably an indicator of the potential liver cell damage associated with an increased risk of CVD (20).…”

Section: Introductionmentioning

confidence: 99%

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U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension

Shi

et al. 2020

Preprint

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Abstract Background: Previous studies indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain an uncertainty and had limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertension male subjects aged 27-93 years was included in the current study. The outcome was a peripheral arterial disease (PAD), defined as present when ABI of either sides was ≤ 0.90.Results: Of 5,129 hypertension male participants, 194 (3.78%) had PAD, and the median serum concentrations of TBiL were 14.10 μmol/L (interquartile range 11.00 to18.60 μmol/L). Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased risk of PAD for participants in both Q1 (OR,1.49; 95%CI: 1.04-2.14) and Q4 (OR,1.70; 95%CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and PAD, and calculated the inflection point was 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of an inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point, respectively. Similar results were found in various subgroups.Conclusions: This cross-sectional study had shown that there was a U-shaped curve for the risk of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension

Shi

et al. 2020

Preprint

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“…One Map Policy atau Kebijakan Satu Peta, Informasi Geospasial diperlukan oleh instansi pemerintah dan masyarakat di semua tingkatan untuk meningkatkan kualitas pengambilan keputusan dalam semua aspek pembangunan nasional (Dinarsih & Eddy, 2017). KSP bertujuan untuk membuat peta yang mengacu pada Satu Georeferensi, Satu GeoStandard, Satu Geodatabase, dan Satu GeoCustodian pada tingkat akurasi skala peta 1: 50.000.…”

Section: Pendahuluanunclassified

Teknik Ortorektifikasi Citra Pleiades Daerah Kabupaten Morowali Sulawesi Tengah Menggunakan Metode Aproksimasi

Riyadi

Arif

Massinai

2019

SNG

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Salah satu permasalahan yang menyebabkan rendahnya efisiensi penggunaan data citra penginderaan jauh ialah penggunaan georeferensi yang beragam baik itu pada data citra maupun data geospasial dan sejenisnya sehingga sering mengakibatkan tumpang tindih interpretasi lahan, ketidakakuratan dan kurang optimal dalam pemanfaatannya. Penggunaan citra resolusi tinggi semakin meningkat dikarenakan dengan tingginya daya guna yang dimiliki untuk perencanaan pembangunan yang berkelanjutan di Indonesia. Penelitian ini dilakukan dengan tujuan untuk umum untuk mendukung Kebijakan Satu Peta (KSP) atau One Map Policy dan menerapkannya dalam program nawacita dari pemerintah Indonesia dengan tujuan khusus menentukan secara manual titik GCP dan menghasilkan data citra Pleiades Morowali yang ter-ortorektifikasi. Data citra mentah Pleiades, data DEM, data titik-titik Ground Control Point (GCP) daerah Morowali kemudian dikumpulkan untuk melakukan proses ortorektifikasi dalam software PCI Geomatica menggunakan metode aproksimasi, dimana didapatkan hasil input data citra yang telah ter-ortorektifikasi dengan nilai RMSer yaitu 0.99 dan akurasi horizontal sebesar 1.97 Meter yang kemudian dibuatkan layout hasil ortorektifikasi citra Pleiades yang telah memenuhi persyaratan sistem georeferensi yang terintegrasi demi mendukung urgensi kebutuhan Indonesia dalam mencapai target kebijakan KSP ini.

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“…Bilirubin is a potent antioxidant under physiological conditions; a higher TBiL level could be a protective factor for atherosclerosis [13]. At the same time, some studies have shown that elevated TBiL levels were negatively correlated with coronary artery disease (CAD) [14][15][16], arterial stiffness [12], and PAD [17][18][19]. Excessive TBiL is probably an indicator of the potential liver cell damage associated with an increased risk of CVD [20].…”

Section: Introductionmentioning

confidence: 99%

U-shaped association between serum bilirubin levels and peripheral arterial disease in Chinese males with hypertension

Shi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Previous studies have indicated that serum total bilirubin might play an important role in peripheral artery disease (PAD). However, the effects of different levels of serum total bilirubin (TBiL) on PAD development remain uncertain, and there are limited data in male participants. We aimed to examine the prevalence of PAD and TBiL among Chinese male adults with hypertension.Methods: A total of 5129 hypertensive male subjects aged 27-93 years were included in the current study. The outcome was peripheral arterial disease (PAD), defined as present when the ABI of either side was ≤ 0.90.Results: Of 5129 hypertensive male participants, 194 (3.78%) had PAD, and the mean serum total bilirubin was 15.67 (7.76) μmol/L. Compared to participants in Q2-Q3 of LgTBiL, there was a significantly increased prevalence of PAD for participants in both Q1 (OR, 1.49; 95% CI: 1.04-2.14) and Q4 (OR, 1.70; 95% CI: 1.16-2.48). After adjusting for potential confounders, a nonlinear U-shaped relationship was detected between TBiL and the prevalence of PAD, and the inflection point was calculated to be 1.08 (LgTBiL = 1.08, TBiL = 12.02 μmol/L). The ORs (95% CIs) were 0.11 (0.02, 0.83) on the left side of the inflection point and 5.26 (1.59, 17.38) on the right side of the inflection point. Similar results were found in various subgroups.Conclusions: This cross-sectional study showed that there was a U-shaped curve for the prevalence of PAD with TBiL concentration in Chinese males with hypertension, with a turning point at 12.02 μmol/L.

show abstract

High serum bilirubin is associated with lower prevalence of peripheral arterial disease among cardiac patients

Cited by 22 publications

References 49 publications

U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension

U-Shaped Association Between Serum Bilirubin Levels and Peripheral Arterial Disease in Chinese Males with Hypertension

Teknik Ortorektifikasi Citra Pleiades Daerah Kabupaten Morowali Sulawesi Tengah Menggunakan Metode Aproksimasi

U-shaped association between serum bilirubin levels and peripheral arterial disease in Chinese males with hypertension

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