High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Kishida, Ken; Nakagawa, Yasuhiko; Kobayashi, Hironori; Mazaki, Toru; Yokoi, Hiroyoshi; Yanagi, Koji; Funahashi, Tohru; Shimomura, Iichiro

doi:10.1186/1475-2840-13-9

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…The amount of C1q–APN complex was significantly higher in the blood of patients with CAD than in the controls with no CAD. Our result is concordant with the other study that serum C1q-APN levels were significantly higher in the acute coronary syndrome than in the normal coronary group [ 26 ]. Recently, the protein family C1q/TNF-related protein (CTRP) has been discovered as adiponectin paralog.…”

Section: Discussionsupporting

confidence: 94%

The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

Hong

Lim

Choi

et al. 2015

Cardiovasc Diabetol

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BackgroundThe complement component C1q triggers activation of the classical immune pathway and can bind to adiponectin (APN). Recently, some studies have been reported that serum C1q-APN/total APN ratio correlates with atherosclerosis and coronary artery disease (CAD). We assessed the relationships between C1q related variables and the severity of CAD, and investigated the localization of the C1q–APN complex.MethodsThe sample included 153 subjects comprising healthy controls and patients with subclinical or overt CAD. We measured the serum concentrations of C1q, total APN, and high-molecular weight (HMW)-APN, and the amount of C1q–APN complex. We identified the sites of C1q–APN complex deposition in various adipose tissues and blood vessels.ResultsSerum concentrations of C1q and HMW-APN and the C1q/HMW-APN ratio were independently associated with the severity of coronary stenosis. The amount of C1q–APN complex was significantly higher in patients with CAD compared with controls. C1q and APN co-localized in perivascular areas of subcutaneous, visceral, and pericardial fat tissues, and the internal mammary artery of patients with severe CAD.ConclusionsSerum C1q concentration and the C1q/HMW-APN ratio were independent markers of coronary artery stenosis. The amount of C1q–APN complex was significantly greater in serum from CAD patients. C1q and APN co-localized to perivascular areas in adipose tissue and blood vessels. The association between the increased amount of the C1q–APN complex and CAD should be investigated further.

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Section: Discussionsupporting

confidence: 94%

The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

Hong

Lim

Choi

et al. 2015

Cardiovasc Diabetol

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“…The increased C1q activity inhibited local inflammatory response in peripheral blood by combining with adiponectin. Therefore, it is an active defense against acute cardiovascular events and helps maintain autoimmune tolerance ( 55 ). Regrettably, ROC curve suggested that the accuracy in CAD by serum complement C1q activity was low.…”

Section: Discussionmentioning

confidence: 99%

Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease

Guo

Mao

et al. 2021

Front. Cardiovasc. Med.

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Background: Complement C1q plays a dual role in the atherosclerosis. Previous studies showed inconsistent results about the association of serum C1q levels and coronary artery disease (CAD). Here, we explored the associations of serum C1q activity with CAD, coronary stenosis severity, cardiovascular biomarkers, and 1-year restenosis after coronary artery revascularization.Methods: We enrolled 956 CAD patients and 677 controls to evaluate the associations of serum complement C1q activity to the presence and severity of obstructive CAD and non-obstructive CAD. Serum C1q activity and the concentrations of laboratory markers were measured in all subjects. All the data were analyzed using SPSS22.0 software.Results: Serum C1q activity in Obstructive CAD and Non-Obstructive CAD groups was significantly higher than the control group (195.52 ± 48.31 kU/L and 195.42 ± 51.25 kU/L vs. 183.44 ± 31.75 kU/L, P < 0.05). Greater C1q activity was significantly correlated with higher total cholesterol (TC) and triglyceride (TG) levels. C1q activity was associated with an increased Odds Ratio (OR) of CAD (OR = 1.322, 95% CI 1.168–1.496, P < 0.05) and 1-year restenosis after revascularization (the highest OR = 3.544, 95% CI 1.089–12.702, P < 0.05). Complement C1q activity was not correlated with Gensini score in the Obstructive CAD group after adjustment for confounders. C1q activity has low value in predicting the incidence of CAD.Conclusion: Serum complement C1q activity is associated with obstructive CAD.

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“…In the present study, PGZ addition enhanced the mRNA expression of PPARγ , PGC-1α and FABP3 , demonstrating an upregulated transport and accretion of fatty acids in the muscle of PGZ-fed animals. As a PPARγ agonist, PGZ has been shown to enhance the secretion of adipokines and increase adipocyte differentiation of progenitor cells ( Czarnowska et al., 2016 ; Kishida et al., 2014 ). Moreover, the IMF also increased in the longissimus thoracis muscle by activating PGC-1α and FABP3 ( Chen et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with pioglitazone hydrochloride and l-carnosine improves the growth performance, muscle fatty acid profiles and shelf life of yellow-feathered broiler chickens

et al. 2021

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The present study aimed to investigate the effects of dietary pioglitazone hydrochloride (PGZ) and l -carnosine (LC) supplementation on the growth performance, meat quality, antioxidant status, and meat shelf life of yellow-feathered broiler chickens. Five hundred broiler chickens were randomly assigned into 4 experimental diets using a 2 × 2 factorial arrangement with 2 PGZ supplemental levels (0 and 15 mg/kg) and 2 LC supplemental levels (0 and 400 mg/kg) in basal diets for 28 d. The feed-to-gain ratio decreased whereas the average daily gain increased with PGZ supplementation. Greater dressing percentages, contents of intramuscular fat (IMF) in breast and thigh muscles, C18:3n-6, C18:1n-9 and monounsaturated fatty acid (MUFA) percentages of thigh muscle were observed with PGZ addition. Additionally, significant synergistic effects between PGZ and LC on the C18:1n-9 and MUFA contents were found. Supplementation with LC decreased drip loss, cooking loss and total volatile basic nitrogen, and increased the redness ( a ∗) value, the superoxide dismutase and glutathione peroxidase activities in thigh muscles. Moreover, the malondialdehyde content decreased when diets were supplemented with LC, and there was a synergistic effect between PGZ and LC. Additionally, the mRNA abundance of lipogenesis-related genes, such as peroxisome proliferator-activated receptor γ ( PPARγ ), PPARγ co-activator 1α and fatty acid-binding protein 3, increased with PGZ supplementation, and relevant antioxidation genes, such as nuclear factor erythroid-2-related factor 2 and superoxide dismutase 1, were enhanced with LC supplementation. In conclusion, the results indicated that the supplementation of PGZ and LC could improve the growth performance, antioxidant ability, IMF content, and meat shelf life of yellow-feathered broiler chickens.

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High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Cited by 12 publications

References 35 publications

The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

Serum Complement C1q Activity Is Associated With Obstructive Coronary Artery Disease

Dietary supplementation with pioglitazone hydrochloride and l-carnosine improves the growth performance, muscle fatty acid profiles and shelf life of yellow-feathered broiler chickens

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