High serum concentration of selenium, but not calcium, cobalt, copper, iron, and magnesium, increased the risk of both hyperglycemia and dyslipidemia in adults: A health examination center based cross-sectional study

Liu, Aiping; Xu, Ping; Gong, Chunmei; Zhu, Yong; Zhang, Huimin; Nie, Wenjing; Zhou, Xiaoying; Liang, Xiongshun; Xu, Yuanfei; Huang, Changhua; Liu, Xiaoli; Zhou, Jinchuan

doi:10.1016/j.jtemb.2020.126470

Cited by 34 publications

(26 citation statements)

References 62 publications

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“…For example, hair Se levels were higher in subjects with obesity, although no effect of diabetes was observed in this research [57]. In a recently published cross-sectional study in an adult Chinese population, serum Se concentration was positively associated with the risks of both hyperglycemia and dyslipidemia, and both these metabolic disorders had higher BMI than their respective controls [58]. Although high serum Se levels were associated with increased BMI (23.9 ± 2.9 (Q1) vs. 25.5 ± 4.0 (Q4), p < 0.001), as well as other markers of MetS, the association between increased Se supply and insulin resistance was found to be obesity-independent [59].…”

Section: Se Blood Levels and Intake Patternscontrasting

confidence: 44%

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

et al. 2020

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Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.

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Section: Se Blood Levels and Intake Patternscontrasting

confidence: 44%

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

et al. 2020

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“…Focusing on factors related to serum magnesium concentrations, no statistically significant differences were detected per sex, age, BMI, or smoking status in our population. These factors have been analyzed in various studies [15,53,55,63,77,86], obtaining different results depending on the population analyzed. Mataix et al [15], in a study undertaken to identify factors influencing plasma magnesium levels in the general population of southern Spain, and in agreement with our results, did not observe any association between plasma levels of magnesium and sex, age, obesity, tobacco smoking, alcohol drinking, educational level or sedentarism.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, in observational studies, the results regarding total cholesterol and LDL-cholesterol are inconclusive [38]. Some studies showed a statistically significant inverse association between plasma magnesium and total or LDL-cholesterol [95,96], but other studies did not observe any significant association [38,55,57,97]. Moreover, there are numerous publications [53,56,57,98,99], that, in agreement with our results, found statistically significant direct associations between plasma magnesium concentrations and total and/or LDL-cholesterol levels, but they did not emphasize the findings.…”

Section: Discussionmentioning

confidence: 99%

“…Several prospective cohort studies have analyzed plasma magnesium concentrations and cardiovascular disease incidence and diabetes risk, and some of them reported inverse associations in a meta-analysis [51]. Although at the cross-sectional level numerous researchers have investigated associations between plasma magnesium concentrations and cardiovascular risk factors including plasma lipids, blood pressure, fasting glucose/diabetes, inflammation markers, among others, the consistency (except for type-2 diabetes), is still low [14,[52][53][54][55][56][57][58]. Therefore, further studies are required on different populations in order to better understand those associations as well as the demographic and lifestyle factors associated with plasma magnesium concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

et al. 2020

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Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize the biases derived from diet measurement, more objective biomarkers of magnesium status have been proposed. Although there is still no ideal biomarker for Mg, several studies have shown that plasma Mg concentrations could be a relatively acceptable biomarker for cardiovascular risk assessment. However, further studies are required to better characterize this marker in different populations. Our aim was to analyze the association between plasma Mg concentrations (measured through inductively coupled plasma mass spectrometry (ICP-MS)) methods, and cardiovascular risk factors in individuals from a general Mediterranean population (aged 18–80 years). The influence of demographic and lifestyle variables, including adherence to the Mediterranean diet, on plasma Mg concentrations was analyzed. The mean Mg level of the population studied was 0.77 ± 0.08 mmol/L, the prevalence of hypomagnesemia (<0.70 mmol/L) being 18.6%. We did not find any statistically significant differences between plasma Mg concentrations and sex, age, tobacco smoking and total adherence to the Mediterranean diet (p > 0.05). We found a statistically significant association between plasma Mg concentrations and the prevalence of type-2 diabetes (0.77 ± 0.08 mmol/L in non-diabetics versus 0.73 ± 0.13 mmol/L in diabetics; p = 0.009). Despite the low prevalence of type-2 diabetes in this population (11.24% in subjects with hypomagnesemia versus 3.91%, in normomagnesemia; p = 0.005), hypomagnesemia was associated with greater odds of being diabetic in comparison with normomagnesemia (OR = 3.36; p = 0.016, even after adjustment for sex, age, obesity, and medications). On the other hand, no statistically significant association of plasma Mg concentrations with obesity, hypertension, fasting triglycerides, HDL-cholesterol or uric acid was found. However, in contrast to what was initially expected, a statistically significant association was found between plasma Mg concentrations (basically in the highest quartile) and greater total cholesterol (p < 0.05) and LDL-cholesterol concentrations (p < 0.05). In conclusion, our results contribute to increasing the evidence gathered by numerous studies on the inverse association between hypomagnesemia and type-2 diabetes, as well as to the observation, previously reported in some studies, of a direct association with hypercholesterolemia. This paradoxical link should be deeply investigated in further studies.

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“…Regarding the association of selenium with total cholesterol and LDL-c, some studies show a direct association in the general population [48,49], while others display a negative correlation [50,51] or no association at all [52]. This inconsistency may be due to the sample size or even the lack of adjustment for confounding variables.…”

Section: Table 3 Comparison Of Biochemical Variables Of A-t Patients mentioning

confidence: 99%

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Andrade

Souza

Fonseca

et al. 2021

Orphanet J Rare Dis

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Introduction Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 μg/L (43.2–57.0) vs 54.6 (45.2–62.6) μg/dL, p = 0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I1, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p = 0.029] and lower Apo-A-I1/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p = 0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC = 0.849) and ALT (AUC = 0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

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High serum concentration of selenium, but not calcium, cobalt, copper, iron, and magnesium, increased the risk of both hyperglycemia and dyslipidemia in adults: A health examination center based cross-sectional study

Cited by 34 publications

References 62 publications

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity

Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

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