High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis

Abstract

We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher (P‐value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune‐activation, and 76.2% patients had features of immune‐pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH.

Haemophagocytic lymphohistiocytosis: case series. Serum ferritin level as an indicator of treatment effectiveness

“…Lin et al [21] presented the usefulness of regular ferritin measurements in predicting treatment outcomes in patients with HLH. Additionally, Kohli et al [22] showed that high serum ferritin levels are highly predictive of mortality and morbidity.…”