High Serum Homocysteine Levels in Young Male Schizophrenic and Schizoaffective Patients With Tardive Parkinsonism and/or Tardive Dyskinesia

Lerner, Vladimir; Miodownik, Chanoch; Kaptsan, Alexander; Vishne, Tali; Sela, Ben‐Ami; Levine, Joseph

doi:10.4088/jcp.v66n1210

Cited by 14 publications

(10 citation statements)

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“…Interestingly, in spite of the marked difference in plasma homocysteine levels, no differences were observed in cerebrospinal fluid levels between SZ patients and controls . In at least one report, elevated plasma homocysteine was linked to tardive movement disorders (Lerner et al, 2005). Followup studies confirmed the original finding that elevated homocysteine was associated with SZ and suggested that a common polymorphism (677 C4T) in the MTHFR gene might be responsible (Muntjewerff et al, 2006).…”

Section: One Carbon Metabolism and Szmentioning

confidence: 79%

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Grayson

Guidotti

2012

Neuropsychopharmacol

244

214

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Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with psychosis (BP+ ) express a complex symptomatology characterized by positive symptoms, negative symptoms, and cognitive impairment. Postmortem studies of human SZ and BP+ brains show considerable alterations in the transcriptome of a variety of cortical structures, including multiple mRNAs that are downregulated in both inhibitory GABAergic and excitatory pyramidal neurons compared with non-psychiatric subjects (NPS). Several reports show increased expression of DNA methyltransferases in telencephalic GABAergic neurons. Accumulating evidence suggests a critical role for altered DNA methylation processes in the pathogenesis of SZ and related psychiatric disorders. The establishment and maintenance of CpG site methylation is essential during central nervous system differentiation and this methylation has been implicated in synaptic plasticity, learning, and memory. Atypical hypermethylation of candidate gene promoters expressed in GABAergic neurons is associated with transcriptional downregulation of the corresponding mRNAs, including glutamic acid decarboxylase 67 (GAD67) and reelin (RELN). Recent reports indicate that the methylation status of promoter proximal CpG dinucleotides is in a dynamic balance between DNA methylation and DNA hydroxymethylation. Hydroxymethylation and subsequent DNA demethylation is more complex and involves additional proteins downstream of 5-hydroxymethylcytosine, including members of the base excision repair (BER) pathway. Recent advances in our understanding of altered CpG methylation, hydroxymethylation, and active DNA demethylation provide a framework for the identification of new targets, which may be exploited for the pharmacological intervention of the psychosis associated with SZ and possibly BP+ .

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Section: One Carbon Metabolism and Szmentioning

confidence: 79%

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Grayson

Guidotti

2012

Neuropsychopharmacol

244

214

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“…The correlations between hyperhomocysteynaemia and Parkinson's disease (29), tardive dyskinesia or severe extra pyramidal symptoms induced by neuroleptic drugs (30) have been explained as a special vulnerability of D2-dopamine receptors to the toxic effect of Hcy (31).…”

Section: Hyperhomocysteinaemia and Degenerative Processesmentioning

confidence: 99%

Homocysteine levels in schizophrenia patients newly admitted to an acute psychiatric ward

Lorenzo

Amoretti²,

Baldini³

et al. 2015

Acta Neuropsychiatr.

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“…In fact, young male patients with schizoaffective disorders and at least one year of neurolepticinduced tardive movement disorders (TMD) -like tardive parkinsonism, tardive akatisia or tardive tremor -have levels of homocysteine higher than schizoaffective patients without TMD [55]. Regression analysis showed that age groups, sex and the presence of TMD -but not diagnosis -significantly influenced homocysteine levels [55]. Another study on patients with schizophrenia [56], found a positive correlation between homocysteine serum concentration and extrapyramidal symptoms, with gender, rather than age, as strong predictor.…”

Section: Are There Reasons Different From L-dopa Intake For Hyperhomomentioning

confidence: 99%

Homocysteine and Parkinson's disease: A dangerous liaison?

Martignoni

Tassorelli

Nappi

et al. 2007

Journal of the Neurological Sciences

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High Serum Homocysteine Levels in Young Male Schizophrenic and Schizoaffective Patients With Tardive Parkinsonism and/or Tardive Dyskinesia

Cited by 14 publications

References 0 publications

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Homocysteine levels in schizophrenia patients newly admitted to an acute psychiatric ward

Homocysteine and Parkinson's disease: A dangerous liaison?

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