High serum level of soluble CD30 in acute primary HIV-1 infection

Pizzolo, Giovanni; Vinante, Fabrizio; Nadali, Gianpaolo; Krampera, Mauro; Morosato, L.; Chilosi, Marco; Raiteri, Riccardo; Sinicco, Alessandro

doi:10.1046/j.1365-2249.1997.d01-1005.x

Cited by 48 publications

(36 citation statements)

References 16 publications

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“…[12][13][14][15][16][17][18][19] Analyses of other immune activation markers such as soluble CD30 (tumor necrosis factor receptor superfamily, member 8) can be equally informative. [20][21][22] In addition, detection of intracellular cytokines, especially IFN-g, IL-2, and TNF-a, is increasingly used to gauge the functionality of HIVspecific T cells. 23,24 However, with few exceptions, 25 past research has rarely yielded longitudinal data that can elucidate the timing and trajectory of cytokine or chemokine profile after HIV-1 infection.…”

Section: Introductionmentioning

confidence: 99%

“…Of note, the three products (IL-10, IL-18, and soluble CD30) positively correlated with HIV-1 VL and inversely so with CD4 counts are all markers of immune activation, which is consistent with evidence from previous studies featuring different demographic characteristics. 13,17,[20][21][22]37,38 Among the three analytes, IL-10 has the best defined function properties in viral infection or clearance. [39][40][41] Compared with IL-18 and soluble CD30, use of plasma IL-10 as a biomarker for HIV-1 pathogenesis per se is somewhat compromised by its lack of persistent correlation with CD4 decline during HIV-1 infection (Table 3) and by its apparent fluctuation even in healthy subjects (Table 4).…”

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confidence: 99%

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Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth

Song

Li²,

Wilson³

et al. 2011

AIDS Research and Human Retroviruses

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To evaluate the stability and heterogeneity of cytokine and chemokine profiles in 80 youth with and without HIV-1 infection, we tested plasma samples at repeated visits without antiretroviral therapy. Among nine analytes that were quantified using multiplexing assays, interleukin 10 (IL-10), IL-18, and soluble CD30 persistently showed a positive correlation with HIV-1 viral load (Spearman r ¼ 0.40-0.59, p < 0.01 for all). A negative correlation with CD4 þ T cell counts (r ¼ À0.40 to À0.60, p < 0.01 for all) was also persistent for the three analytes. Analyses restricted to 48 AIDS-free youth (96 visits) yielded similar findings, as did multivariable models in which race, sex, age, body mass index, and time interval between visits were treated as covariates. These relationships reflected two novel features observed for all three analytes. First, their presence in plasma was relatively stable between visits (r ¼ 0.50-0.90, p < 0.03), regardless of HIV-1 infection status. Second, pairwise correlation was strong and persistent in HIV-1-seropositive youth (r ¼ 0.40-0.59, p < 0.01), but not in HIV-1, seronegatives ( p > 0.13). Additional analytes, especially eotaxin/CCL11 and SDF-1b/CXCL12, had no correlation with HIV-1-related outcomes despite their stability between visits. Overall, circulating IL-10, IL-18, and soluble CD30 could partially track unfavorable responses to HIV-1 infection in youth. These markers of persistent immune activation are individually and collectively indicative of HIV-1 pathogenesis.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth

Song

Li²,

Wilson³

et al. 2011

AIDS Research and Human Retroviruses

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“…In regard to HIV infection, elevated levels of the soluble form of CD30, sCD30, are predictors of progression to AIDS [15] and are also correlated with HIV viremia levels and clinical outcome in patients with primary HIV infection [16,17]. A direct link between CD30 and HIV replication is indicated by the demonstration that triggering of This range of CD30 expression was confirmed also by using primary non-conjugated anti-CD30 mAb (M44 and M67) followed by a FITC-and a PE-conjugated secondary Ab (data not shown), with Molt-3 and MT-2 at the minimum and maximum ends, respectively, and ACH-2, A301 and U937 Plus in the middle range.…”

Section: Introductionmentioning

confidence: 99%

CD30 ligation differentially affects CXCR4‐dependent HIV‐1 replication and soluble CD30 secretion in non‐Hodgkin cell lines and in γ δ T lymphocytes

et al. 2003

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We studied whether signaling through CD30, a member of the TNF receptor family, affected acute infection with HIV-1, encompassing its entire replicative cycle. Several non-Hodgkin cell lines, targets of CXCR4-dependent (X4) HIV-1 infection, were positive for CD30 expression. CD30 ligation induced up-regulation of viral replication only in certain CD30 + cell lines. Enhancement of X4 virus replication by CD30 engagement inversely correlated with both CD30 surface density and constitutive NF-‹ B activation. Conversely, expression of CD30, but not of other members of the TNF receptor family, was proportional to constitutive NF-‹ B binding. Concomitantly, secretion of soluble (s) CD30 increased in all cell lines by CD30 ligation. sCD30 release was enhanced by engagement of CD30 alone and, to a greater extent, by co-engagement of CD3 also in primary +ˇT lymphocytes, along with complementary modulations of their surface CD30 expression. sCD30-containing supernatant specifically inhibited HIV-1 expression induced by CD30 engagement in chronically infected ACH-2 T cells; thus sCD30 may act as a negative feed-back molecule. In conclusion, we have delineated novel features of CD30 biology and underline the peculiar link of CD30 expression to constitutive NF-‹ B activation which is pivotal to both HIV replication and cell survival.

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“…In addition, high serum concentrations of sCD30 have been detected in patients during the acute phase of viral infections, such as HIV-1 [30], Epstein-Barr virus infection [92], and chronic hepatitis B [31,32]. However, conflicting results have been reported about serum concentrations of sCD30 in patients with bacterial infections, such as tuberculosis [35] and Lyme disease [34].…”

Section: Intravascular Inflammation: a Physiologic Finding In Normal mentioning

confidence: 99%

“…High serum concentrations of sCD30 have been found in the acute phase of viral infections, such as HIV-1 [30] and chronic hepatitis B [31,32]. However, conflicting evidence have been reported concerning serum sCD30 concentration in patients with bacterial infections [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis

Kusanovic

Romero

Espinoza

et al. 2007

The Journal of Maternal-Fetal & Neonatal Medicine

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Objectives-Normal pregnancy is characterized by activation of the innate immunity and suppression of the adaptive limb of the immune response. However, pregnant women are more susceptible to the effects of infection and microbial products than non-pregnant women. CD30 is a member of the tumor necrosis factor receptor superfamily and is preferentially expressed by activated T cells producing Th2-type cytokines. Its soluble form (sCD30) is proposed to be an index of Th2 immune response. High serum concentrations of sCD30 have been found in the acute phase of viral infections, such as HIV-1 and hepatitis B. There is, however, conflicting evidence about serum sCD30 concentration in patients with bacterial infections. The objective of this study was to determine whether there are changes in the serum concentration of sCD30 in pregnant women with pyelonephritis.Methods-This cross-sectional study included normal pregnant women (N=89) and pregnant women with pyelonephritis (N=41). Maternal serum concentration of sCD30 was measured by a specific and sensitive enzyme-linked immunoassay. Non-parametric tests were used for comparisons. A p value <0.05 was considered statistically significant.Results-(1) Pregnant women with pyelonephritis had a significantly higher median serum concentration of sCD30 than those with a normal pregnancy (median: 44.3 U/ml, range: 16-352.5 vs. median: 29.7 U/ml, range: 12.2-313.2, respectively; p<0.001); and (2) No significant differences were found in the median maternal serum concentration of sCD30 between pregnant women with pyelonephritis who had a positive blood culture compared to those with a negative blood culture (median:47.7 U/mL, range: 17.1-118.8 vs. median: 42.6 U/mL, range: 16-352.5, respectively; p=0.86

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High serum level of soluble CD30 in acute primary HIV-1 infection

Cited by 48 publications

References 16 publications

Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth

Identification of Three Immunologic Correlates for HIV Type 1 Pathogenesis in Youth

CD30 ligation differentially affects CXCR4‐dependent HIV‐1 replication and soluble CD30 secretion in non‐Hodgkin cell lines and in γ δ T lymphocytes

Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis

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