High Serum Levels of Caspase-3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage

Lorente, Leonardo; Martı́n, Marı́a; Pérez-Cejas, Antonia; González-Rivero, Agustín F.; Sabatel, Rafael; Ramos, Luís; Argüeso, Mónica; Solé‐Violán, Jordi; Cáceres, Juan J.; Jiménez, Alejandro; Garcı́a-Marı́n, Vı́ctor

doi:10.1007/s12028-020-01012-3

Cited by 5 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[98][99][100] In a study performed by our team with 145 patients with HCC undergoing LT, higher levels of caspase-3 in blood before LT were found in patients who died during the first year of LT than in survivors at 1 year. [101] These findings are in line with those of other studies reporting an association between high blood caspase-3 levels and an increased risk of mortality in patients with sepsis, [102] cerebral infarction, [103] traumatic brain injury [104] or cerebral hemorrhage. [105] The use of different agents decreased apoptosis and improved prognosis in animal models of sepsis, [106] traumatic brain injury, [107] cerebral infarction [108] and cerebral hemorrhage.…”

Section: Caspase-3supporting

confidence: 90%

Circulating biomarkers of mortality prediction in patients undergoing liver transplantation due to hepatocellular carcinoma

Lorente

2023

GIT

View full text Add to dashboard Cite

There are different macromorphological factors obtained prior to liver transplantation (LT) to predict the prognosis of hepatocellular carcinoma (HCC) patients undergoing LT. The use of blood biomarkers could help improve the prognosis prediction of these patients. Blood levels of alpha-fetoprotein (AFP) are the first and most studied prognostic blood biomarkers of HCC patients undergoing LT. This review is to summarize the evidence of prognostic blood biomarkers for HCC patients undergoing LT. A higher mortality rate has been found with high blood levels of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), C-reactive protein (CRP), albumin-bilirubin (ALBI) score, des-gamma-carboxy prothrombin (DCP), lactate dehydrogenase (LDH), gamma glutamyl transpeptidase (GGT), fibrinogen, vascular endothelial growth factor (VEGF), homocysteine, Golgi protein 73 (GP73), substance P, soluble CD40 ligand (sCD40L), caspase-cleaved cytokeratin (CCCK)-18, caspase-3, malondialdehyde and oxidized guanine species (OGS). A higher mortality rate has been found with low blood levels of lymphocyte-to-monocyte ratio (LMR), PD-L1, Galectin-9, total antioxidant capacity (TAC) and melatonin. Moreover, some studies with small sample sizes associate blood levels of metabolites and microRNAs (MIRs) with the prognosis of HCC patients undergoing LT. More research is warranted to determine the possible utility of these biomarkers to predict the prognosis of HCC.

show abstract

Section: Caspase-3supporting

confidence: 90%

Circulating biomarkers of mortality prediction in patients undergoing liver transplantation due to hepatocellular carcinoma

Lorente

2023

GIT

View full text Add to dashboard Cite

show abstract

“…Patients with SIH tend to have severe neurological impairment when they are admitted to the hospital. Several studies have indicated that intracerebral hemorrhage volume, herniation, intraventricular hemorrhage, admitted GCS have been associated with prognostic outcomes of intracerebral hemorrhage patients 1,13,14. Our data also indicated that compared with successful-removal urinary catheter group, the failed-removal urinary catheter group has higher intracerebral hemorrhage volume ( P <0.001), herniation ( P <0.001), intraventricular hemorrhage ( P <0.001), and lower admitted GCS ( P <0.001).…”

Section: Discussionsupporting

confidence: 57%

“…S pontaneous intracerebral hemorrhage (SIH) accounts for almost 10% to 15% of all strokes, which leads to significant morbidity and mortality. 1 With the continuous improvement of neurosurgery and therapeutic technics, the outcomes of patients with SIH have significantly improved. However, survivors with long-term severe neurological deficits have can become a heavy burden for society and family.…”

mentioning

confidence: 99%

Analysis of the Failure of Removal of the Urinary Catheter for Patients With Intracerebral Hemorrhage Postoperatively

Zhou¹,

He²,

Liu³

et al. 2022

The Neurologist

View full text Add to dashboard Cite

Background: We conducted this study to assess the value of clinically relevant data for predicting the failure of removing urinary catheters among patients with intracerebral hemorrhage postoperatively. Materials and Methods: We retrospectively analyzed the medical records of all patients with intracerebral hemorrhage who underwent surgery for removal of intracerebral hematoma between January 2014 and December 2019, all of whom retained their urinary catheter. The patients were classified into 2 groups. Group A included patients who underwent successful removal of the catheter while group B included patients who underwent a failed removal. Univariate analysis was performed to determine the relationship between the failure of catheter removal and the patients’ preoperative clinical characteristics. Independent prognostic predictors were identified using multivariate analyses. Results: The site of intracerebral hematoma (P=0.004), volume of hematoma (P<0.001), intraventricular hemorrhage (P<0.001), admitted Glasgow Coma Scale (GCS) (P<0.001), GCS before urinary catheter removal (P<0.001), smoking (P=0.011), herniation (P<0.001), urine protein (P=0.013), creatinine (P=0.037), and timing of urinary catheter removal (P<0.001) were significantly different among the 2 groups. Multiple logistical regression analysis indicated that GCS before urinary catheter removal (odds ratio=1.171; 95% confidence interval=1.050-1.306; P=0.005) and timing for urinary catheter removal (odds ratio=0.962; 95% confidence interval=0.944-0.981; P<0.001) were associated with failure of urinary catheter removal. Conclusions: This study demonstrated that GCS before urinary catheter removal and the timing of urinary catheter removal are independent factors associated with failure of urinary catheter removal among patients with intracerebral hemorrhage.

show abstract

“…Some potential biomarkers have been observed in circulating blood of ICH patients. For example, high serum caspase‐3 and oxidized guanine species levels are associated with mortality (Lorente, Martín, González‐Rivero, et al., 2020; Lorente, Martín, Pérez‐Cejas, et al., 2020); however; low serum calcium levels are associated with hematoma expansion and worse outcome (Jafari et al., 2019). Our study demonstrated that higher plasma D‐dimer level, which is a fibrin degradation product, measured within 1 hr of admission, was significantly associated with poor functional outcome and increased mortality at three months in 1,332 patients with ICH, which is consistent with previous reports.…”

Section: Discussionmentioning

confidence: 99%

Plasma D‐dimer predicts poor outcome and mortality after spontaneous intracerebral hemorrhage

et al. 2020

View full text Add to dashboard Cite

Background The elevation of plasma D‐dimer levels may predict a higher risk of thrombosis and play a role in the pathological process of patients after spontaneous intracerebral hemorrhage (ICH). However, its function in predicting the prognosis of ICH has not been verified on large cases. Patients and Methods Retrospective cohort study of 1,332 consecutive patients with spontaneous ICH at an academic medical center was conducted. Functional outcome at three months after ICH was dichotomized using the modified Rankin Scale (0–2 versus 3–6). D‐dimer level in blood was analyzed within 1 hr of admission. An ICH outcome score combining D‐dimer level for evaluating poor functional outcome and mortality was tested. Results The proportion of patients with poor functional outcome and mortality at three months was significantly higher in patients with elevated D‐dimer level ( p < .001). Multivariable analysis demonstrated that elevated D‐dimer level was an independent predictor of poor functional outcome (odds ratio 1.486, 95% confidence interval 1.086–2.060, p = .014) and mortality (odds ratio 2.015, 95% confidence interval 1.186–3.423, p = .01). An increasing ICH outcome score combining D‐dimer level was associated with increased poor functional outcome and mortality. Conclusions Elevated plasma D‐dimer level after spontaneous ICH is associated with poor functional outcome and mortality. The study suggests that elevated D‐dimer level has a predictive value for outcome and mortality in patients with spontaneous ICH.

show abstract

High Serum Levels of Caspase-3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage

Cited by 5 publications

References 25 publications

Circulating biomarkers of mortality prediction in patients undergoing liver transplantation due to hepatocellular carcinoma

Circulating biomarkers of mortality prediction in patients undergoing liver transplantation due to hepatocellular carcinoma

Analysis of the Failure of Removal of the Urinary Catheter for Patients With Intracerebral Hemorrhage Postoperatively

Plasma D‐dimer predicts poor outcome and mortality after spontaneous intracerebral hemorrhage

Contact Info

Product

Resources

About