High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study

Szulc, Paweł; Amri, Ez Zoubir; Varennes, Annie; Panaïa‐Ferrari, Patricia; Fontas, Éric; Goudable, J.; Chapurlat, Roland; Breuil, Véronique

doi:10.1016/j.diabres.2016.09.022

Cited by 28 publications

(29 citation statements)

References 47 publications

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“…In men and women, endogenous peripheral levels of oxytocin are high in those with obesity 88,89 and oxytocin levels in different populations across the weight spectrum are correlated with BMI and levels of body fat 66,89-91 . A notable exception is a study showing low levels of oxytocin in adults with obesity compared with adults of a normal weight; thus, oxytocin levels were negatively associated with BMI.…”

Section: Lipid Metabolism and Body Fatmentioning

confidence: 99%

“…Furthermore, higher oxytocin levels were associated with greater odds of metabolic syndrome after adjusting for confounders including leptin levels. 91 . High oxytocin levels were associated with increased central fat and waist circumference, which are surrogate markers for visceral fat 91 .…”

Section: Lipid Metabolism and Body Fatmentioning

confidence: 99%

“…91 . High oxytocin levels were associated with increased central fat and waist circumference, which are surrogate markers for visceral fat 91 .…”

Section: Lipid Metabolism and Body Fatmentioning

confidence: 99%

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The effects of oxytocin on eating behaviour and metabolism in humans

2017

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Section: Lipid Metabolism and Body Fatmentioning

confidence: 99%

Section: Lipid Metabolism and Body Fatmentioning

confidence: 99%

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The effects of oxytocin on eating behaviour and metabolism in humans

2017

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“…While lower oxytocin concentrations were found in obese compared with normal‐weight adults and children, oxytocin levels have also been found to be proportional to body weight . In a large sample of men with metabolic syndrome, oxytocin concentrations were elevated compared with healthy controls, whereas the obese subjects of the present experiment displayed lower baseline oxytocin levels than their lean counterparts. Decreased oxytocin concentrations were reported in patients with metabolic syndrome or diabetes mellitus, suggesting a certain degree of oxytocin deficiency in diabetic patients .…”

Section: Discussionmentioning

confidence: 68%

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Brede

Fehr

Man

et al. 2018

Diabetes Obesity Metabolism

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The hypothalamic neuropeptide oxytocin not only modulates psychosocial function, but also contributes to metabolic regulation. We have recently shown that intranasal oxytocin acutely improves beta-cell responsivity and glucose tolerance in normal-weight men. In the present experiment, we investigated the acute glucoregulatory impact of oxytocin in obese men with impaired insulin sensitivity. Fifteen obese healthy men with an average body mass index of 35 kg/m and an average body fat content of 33% received a single intranasal dose (24 IU) of oxytocin before undergoing an oral glucose tolerance test. Results were analysed according to the oral minimal model and compared with our findings in normal-weight participants. In contrast to the results in normal-weight subjects, oxytocin did not blunt postprandial glucose and insulin excursions in obese men, and moreover failed to enhance beta-cell responsivity and glucose tolerance. These results indicate that pronounced obesity may be associated with a certain degree of resistance to the glucoregulatory impact of exogenous oxytocin, and underlines the need for further investigations into the potential of oxytocin to improve glucose homeostasis in the clinical context.

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“…[17][18][19] The effects on food intake are rapid and sustained, 17,18 with obese rats appearing to be more sensitive to the effects of OT on weight loss than lean animals. 20 In humans, studies have shown that peripheral OT levels are elevated in obesity 21 and the metabolic syndrome, 22 and correlate with BMI and fat mass. 21,22 Conversely, OT concentrations may be lowered in the presence of overt diabetes.…”

Section: Phys I Olog I C Al Effec Tsmentioning

confidence: 99%

Oxytocin therapy in hypopituitarism: Challenges and opportunities

Bhargava

Daughters

Rees

2018

Clinical Endocrinology

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Summary Patients with hypopituitarism display impaired quality of life and excess morbidity and mortality, despite apparently optimal pituitary hormone replacement. Oxytocin is a neuropeptide synthesized in the anterior hypothalamus which plays an important role in controlling social and emotional behaviour, body weight and metabolism. Recent studies have suggested that a deficiency of oxytocin may be evident in patients with hypopituitarism and craniopharyngioma, and that this may be associated with deficits in cognitive empathy. Preliminary data hint at potential benefits of oxytocin therapy in improving these deficits and the accompanying metabolic disturbances that are common in these conditions. However, several challenges remain, including an incomplete understanding of the regulation and mechanisms of action of oxytocin, difficulties in accurately measuring oxytocin levels and in establishing a diagnosis of oxytocin deficiency, and a need to determine both the optimal mode of administration for oxytocin therapy and an acceptable safety profile with long‐term use. This review considers the data linking oxytocin to the neuropsychological and metabolic disturbances evident in patients with craniopharyngioma and hypopituitarism, and describes the challenges that need to be overcome before replacement therapy can be considered as a therapeutic option in clinical practice.

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High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study

Cited by 28 publications

References 47 publications

The effects of oxytocin on eating behaviour and metabolism in humans

The effects of oxytocin on eating behaviour and metabolism in humans

Intranasal oxytocin fails to acutely improve glucose metabolism in obese men

Oxytocin therapy in hypopituitarism: Challenges and opportunities

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