High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients

Abstract

Circulating PCSK9 is associated with NODAT in RTRs. The PCSK9 pathway may contribute to the pathogenesis of NODAT.

Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance

“…The average PCSK9 level in the current study was similar to a that in a Chinese report [ 9 ] and lower than studies conducted in the United States [ 10 ] and Europe [ 8 ]. This discrepancy might suggest racial and ethnic differences between Asians and Caucasians and similarity among Asian countries.…”

“…The precise pathophysiology and relationship between prediabetes and cardiovascular risk are not fully understood; however, considering that PCSK9 is a main regulator of LDLR availability and the shared common denominator of lipid and glucose metabolism, there might be cross-talk between circulating PCSK9 and glycemic status. A previous study shows that PCSK9 level is positively correlated with insulin and HOMA-IR score [ 8 ]. We did not find any statistically significant differences in insulin resistance or BMI among the normal and prediabetes groups.…”

New‐onset diabetes mellitus among patients with glomerular diseases

“…We found that use of antilipid medication modified associations between the identified factors and NODAG (Table ). A postulated mechanism is through increased synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme regulating circulating LDL‐C levels recently found to be independently associated with post‐transplant diabetes . Although LDL‐C levels and antilipid medications were not associated with incident diabetes in this study, the role of PCSK9 in diabetes should be explored further.…”

The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside

“…New‐onset diabetes after transplant (NODAT) is a common and serious complication after all types of solid organ transplant . NODAT is associated with elevated risks of morbidity (eg,, infection, cardiovascular disease, and chronic kidney disease) and mortality .…”

“…New-onset diabetes after transplant (NODAT) is a common and serious complication after all types of solid organ transplant. [1][2][3] NODAT is associated with elevated risks of morbidity (eg,, infection, cardiovascular disease, and chronic kidney disease) and mortality. 3,4 Current known risk factors of NODAT include older age, family history, obesity, hepatitis C virus infection, and immunosuppressive agents.…”