High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults

Ma, Lina; Liu, P.; Zhang, Y.; Sha, Guiming; Zhang, L.; Li, Y.

doi:10.1007/s12603-020-1533-y

Cited by 25 publications

(13 citation statements)

References 8 publications

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“…3 Since each component is associated with adverse health events in older people, recent studies have focused on these components in combination. [6][7][8][9][10][11][12][13][14][15][16] As so, our in-depth understanding of the trajectory of IC decline may enable us to design innovative methods for the promotion of healthy ageing, 17 even during a catastrophic event such as the COVID-19. 18 Although the concept of IC has been used in several studies worldwide, 12 15 16 no studies have been conducted in China.…”

Section: Open Accessmentioning

confidence: 99%

Cross-sectional study examining the status of intrinsic capacity decline in community-dwelling older adults in China: prevalence, associated factors and implications for clinical care

Chhetri

Zhang

et al. 2021

BMJ Open

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ObjectivesIntrinsic capacity (IC) was proposed by the WHO as a new concept for capturing an individual’s functional capacities across their lifetime. We aimed to investigate the prevalence and factors associated with IC decline and examine associations between IC and adverse outcomes among community-dwelling older adults in China.DesignA cross-sectional study.SettingCommunity, China.ParticipantsData were derived from the China Comprehensive Geriatric Assessment Study, a population-based nationally representative sample. IC comprises of five domains: locomotion, cognition, vitality, sensory and psychology. Participants were deemed to have IC decline if they showed a decline in any of the five domains. Sociodemographic characteristics, chronic diseases, geriatric syndromes and adverse outcomes were also examined.ResultsOf the 5823 community-dwelling participants aged 60–98 years, 2506 had IC decline (weighted 39.9%): 57.7% in western, 38.3% in northern, 33.7% in northwest, 36.1% in middle, 16.9% in eastern and 19.8% in northeast China. The number of participants with decline in the locomotion, cognition, vitality, sensory and psychological domains were 1039 (17.8%), 646 (11.1%), 735 (12.6%), 824 (14.2%) and 713 (12.2%), respectively. Age, northern residence, low education, being unmarried, low income, less exercise, less meat intake, insomnia, memory loss, urinary incontinence, constipation, slowness, chronic obstructive pulmonary disease and osteoarthritis were related to IC decline. After adjusting for age, sex, area, district, marriage, education, waist–hip ratio, smoking, alcohol consumption, exercise, income and chronic diseases, IC decline was independently associated with risk of frailty, disability, falls, fractures and immobility.ConclusionThe prevalence of IC decline in China is high. IC decline was significantly associated with adverse outcomes, after adjustment for related variables. Efforts promoting IC to delay functional dependence should focus on modifiable factors, including negative social factors, poor lifestyle, chronic diseases and geriatric syndromes.

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Section: Open Accessmentioning

confidence: 99%

Cross-sectional study examining the status of intrinsic capacity decline in community-dwelling older adults in China: prevalence, associated factors and implications for clinical care

Chhetri

Zhang

et al. 2021

BMJ Open

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“…Moreover, participants with deteriorating IC reported significantly higher levels of plasma N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) than those with normal IC, and the former were associated with abnormal mobility, hearing, vision, and psychological function [ 25 ]. In addition, increased serum tumor necrosis factor receptor 1 (TNFR1) levels were independently associated with reduced IC, suggesting that chronic inflammation may be the basis for decline in IC [ 26 ]. Based on this evidence, some studies have proposed lifestyle interventions [ 27 - 29 ] or supplements of omega-3 (ω-3) polyunsaturated fatty acid (PUFA)— known for its anti-inflammatory effects [ 30 - 34 ]—to mitigate the effects on cognitive impairment [ 27 - 30 , 34 ] and other domains [ 31 - 33 ].…”

Section: Intrinsic Capacity Biomarkersmentioning

confidence: 99%

Intrinsic Capacity in Older Adults: Recent Advances

Zhou

2022

Aging and disease

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“…The allostatic load was a multi-system comprehensive index reflecting disorders of physiological systems by using ten biomarkers of five biological systems (hypothalamic-pituitary-adrenal axis, sympathetic nervous system, inflammatory system, metabolic system, and cardiovascular system), which applied the sex-specific parameters and was calculated as a composite score. 50 Besides, biomarkers that can reflect chronic inflammatory states, such as tumor necrosis factor receptor 1 (TNFR1), 37 C-reactive protein (CRP), 51 and Hcy, have been found to be related to the impairment of IC domains. In the MAPT study, the IC score decreased among participants with hyperhomocysteine during the five-year follow-up, but the group difference between normal Hcy and hyperhomocysteine on IC score did not persist after adjusting for confounders, and only handgrip strength remained significant.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic Capacity Declines with Elevated Homocysteine in Community-Dwelling Chinese Older Adults

Lin¹,

Wang²,

Zheng³

et al. 2022

CIA

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Purpose Intrinsic capacity (IC) reflects the overall health status of older adults and has great public health significance. But few studies described the related biomarkers for IC. The aim of this study was to investigate the association between homocysteine (Hcy) and IC in older adults. Participants and Methods This cross-sectional study included 1927 community-dwelling Chinese older adults aged 60–98 years from May 2020 to December 2020. Data were collected through interviews, physical examinations, and laboratory tests. IC involved five domains of cognition, locomotion, sensory, vitality, and psychology evaluated by the Mini-cog scale, 4-m walk test, self-reported visual and hearing conditions, MNA-SF scale, and GDS-4 scale, respectively. The score of each domain dichotomized as 0 (normal) and 1 (impaired) was added together to an IC total score. Low IC was defined as a score of 3–5, and high IC as 0–2. Hcy was measured by a two-reagent enzymatic assay. A restricted cubic spline regression model was used to explore the non-linear relationship between Hcy and low IC. Results Hcy was higher in the low IC group than in the high IC group. Restricted cubic spline analysis revealed a J-shaped nonlinear association between Hcy and low IC. The risk of IC decline was slowly decreased until 8.53 µmol/L of Hcy (OR=0.753, 95% CI=0.520–1.091, P=0.132), and increased with elevations of per 5 µmol/L Hcy afterwards (OR=1.176, 95% CI=1.059–1.327, P=0.005). Among the five domains of IC, Hcy had ORs of 1.116 (1.009–1.247) for cognition impairment, 1.167 (1.055–1.305) for vitality, and 1.160 (1.034–1.303) for psychology per 5 µmol/L increase in Hcy above the change point. Additional sensitivity analysis also demonstrated the nonlinear association between Hcy and low IC. Conclusion Hcy had a J-shaped association with low IC. Higher Hcy (Hcy ≥8.53µmol/L) might provide clinical implications for early identifying the risk of low IC.

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High Serum Tumor Necrosis Factor Receptor 1 Levels Are Related to Risk of Low Intrinsic Capacity in Elderly Adults

Cited by 25 publications

References 8 publications

Cross-sectional study examining the status of intrinsic capacity decline in community-dwelling older adults in China: prevalence, associated factors and implications for clinical care

Cross-sectional study examining the status of intrinsic capacity decline in community-dwelling older adults in China: prevalence, associated factors and implications for clinical care

Intrinsic Capacity in Older Adults: Recent Advances

Intrinsic Capacity Declines with Elevated Homocysteine in Community-Dwelling Chinese Older Adults

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