High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases

Oki, Yoshitsugu; Kikuchi, Makoto; Minai, Kosuke; Ogawa, Kazuo; Inoue, Yasunori; Morimoto, Satoshi; Tanaka, Toshikazu; Nagoshi, Tomohisa; Ogawa, Takayuki; Yoshimura, Michihiro

doi:10.1038/s41598-018-37053-0

Cited by 13 publications

(9 citation statements)

References 52 publications

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“…43,44 Uric Acid A number of studies indicated a significant association between high UA levels and cardiac functions in patients with cardiovascular disease. [23][24][25] However, our study showed that UA levels did not correlate with morphology, LVEF, or GLS in disease-free obese adolescents, even though higher levels were observed in obese subjects. These results support the Framingham Heart Study findings demonstrated that UA does not correlate with the risk of cardiovascular disease, at least in men.…”

Section: Leptin and Cardiac Functioncontrasting

confidence: 63%

“…Cicoira et al demonstrated that UA levels correlate with diastolic but not systolic dysfunction in ischemic cardiomyopathy patients, whereas other studies found a relationship between UA levels and LVEF in patients with ischemic heart disease and heart failure. [23][24][25][26] However, the relationship between UA and cardiac functions in healthy obese people has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Imerbtham¹,

Thitiwuthikiat²,

Jongjitwimol³

et al. 2020

DMSO

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The purposes of this study were to use speckle tracking echocardiography to confirm the influence of obesity on cardiac functions and to assess their relationships with leptin and uric acid levels in obese adolescents. Methods: Eighty-one participants aged 16-19 years were recruited and classified as either non-obese (n = 30) or obese (n = 51). Global longitudinal strain (GLS), leptin and uric acid levels for each group were assessed and compared. The data from obese participants were then compared based on their leptin levels and analyzed for correlation using regression analysis. Results: The obese group had significantly lower absolute GLS compared to the non-obese group (19.10 ± 0.30 versus 21.10 ± 0.30%, p < 0.001). In obese group, subclinical cardiac dysfunction was worse in the hyperleptinemic group than that of the normoleptinemic group (p = 0.03). Multivariate regression analysis showed that leptin and triglyceride levels were negatively associated with absolute GLS. Leptin could predict the absolute GLS with β = −0.35 (p = 0.02). Conclusion: Subclinical left ventricular systolic dysfunction was found in obese adolescents, while GLS was worse in the hyperleptinemic subjects. Leptin, but not uric acid, levels were associated with a worsening of GLS.

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Section: Leptin and Cardiac Functioncontrasting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Imerbtham¹,

Thitiwuthikiat²,

Jongjitwimol³

et al. 2020

DMSO

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“…The path analysis was performed using the IBM SPSS AMOS software program (version 25, Amos Development Corporation, Meadville, PA, USA). We have previously described how to write a path model [5][6][7][8][9][10][11][12][13][14] . In brief, the current models show the relationship between clinical factors and the LV cavity sizes or LVEF using some hierarchical regression models.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…

of a path diagram due to the solution of some disease status [5][6][7][8][9][10][11][12][13][14] . In this study, we tried to examine the effect of respective risk factors, such as aging, gender difference, body mass index (BMI), hypertension, diabetes, and dyslipidemia, on LV cavity sizes at the timing of systole and diastole in patients with IHD by using SEM.

…”

mentioning

confidence: 99%

Possible diverse contribution of coronary risk factors to left ventricular systolic and diastolic cavity sizes

Suzuki

Inoue

Ogawa

et al. 2021

Sci Rep

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It is generally believed that risk factors damage the coronary arteries, cause myocardial ischemia, and consequently change the shape of the heart. On the other hand, each of the risk factors may also have a negative effect on the heart. However, it is very difficult to examine the effects of each of these risk factors independently. Therefore, it is necessary to select an appropriate statistical method and apply it efficiently. In this study, the effects of coronary risk factors on left ventricular size and cardiac function were investigated using structure equation modeling (SEM), and were shown as Bayesian SEM-based frequency polygons using selected two-dimensional contours. This study showed that each risk factor directly affected the shape of the heart. Because vascular risk and heart failure risk are likely to evolve at the same time, managing risk factors is very important in reducing the heart failure pandemic.

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“…Gender, BMI, HR, LVEF, and LVEDP are widely known to be major determinants of BNP [20][21][22] . Since we recently reported that BNP might be related to HOMA-IR and UA, these two factors were also included in the path diagram [23][24][25] . We excluded patients with arterial fibrillation (AF) (n = 1) and those receiving insulin therapy (n = 8) to reduce possible bias.…”

Section: Concept Of the Proposed Path Model A: Investigation Of The Imentioning

confidence: 99%

A Highly-sensitized Response of B-type Natriuretic Peptide to Cardiac Ischaemia Quantified by Intracoronary Pressure Measurements

Itakura

Inoue

Ogawa

et al. 2020

Sci Rep

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B-type natriuretic peptide (Bnp) secretion is stimulated by cardiac dysfunction. However, it is unclear how finely myocardial ischaemia contributes to BNP secretion and whether increases in BNP secretion contribute to coronary vasodilation. this study investigated the direct interaction between plasma Bnp levels and cardiac ischaemia using the baseline distal-to-aortic pressure ratio (pd/pa). We examined the baseline Pd/Pa and fractional flow reserve (FFR) in 167 patients with intermediate coronary stenosis. the plasma Bnp level appeared to be associated with the baseline pd/pa in the study population, and this association appeared to become clear only in patients with an ffR ≤ 0.80. To examine the effect of the baseline pd/pa on the Bnp level in these patients, structural equation modeling (SeM) was performed. The baseline Pd/Pa significantly affected the BNP level (β: −0.37, p = 0.003) and the left ventricular ejection fraction (β: 0.43, p = 0.001). To examine the role of BNP in coronary vasodilation, we proposed another path model using a novel value obtained by dividing the ffR by the baseline pd/ Pa (FFR/baseline Pd/Pa) as an index of the hyperaemic response. The BNP level significantly affected the ffR/baseline pd/pa (β: 0.48, p = 0.037). This study demonstrated that BNP finely responded to an exacerbation of cardiac ischaemia and that increases in BNP secretion effectively ameliorated coronary vasoconstriction.B-type natriuretic peptide (BNP) is secreted mainly by the ventricles in heart failure, whereas normal atria secrete A-type natriuretic peptide (ANP) as well as BNP 1-5 . ANP and BNP have a wide range of biological effects; for instance, they induce vasodilation and natriuresis and inhibit the renin-angiotensin aldosterone system (RAAS) and the sympathetic nervous system 6,7 . Plasma BNP is elevated in heart failure caused by various heart diseases, including ischaemic heart disease (IHD) 8-10 .Previous reports have shown that myocardial hypoxia associated with a reduction in coronary blood flow increases cardiac BNP expression 11 . Moreover, the BNP level is elevated during early ischaemia, and an elevated BNP level is a significant risk factor for poor short-term and long-term prognoses 12 . Increases in the plasma BNP level are considered a compensatory response of the heart to ischaemia, because several reports have shown that BNP has a vasodilatory effect on the coronary artery system in humans 13,14 . However, it is still unclear how finely myocardial ischaemia itself contributes to BNP secretion and whether increases in BNP secretion actually induce vasodilation as a counter-adaptation. A precise analysis of the relationship between cardiac ischaemia and BNP secretion is the remaining action assignment.Coronary artery pressure wires are widely used in the clinic to assess the degree of coronary stenosis-induced myocardial ischaemia 15,16 . Pressure wires can be used to measure the fractional flow reserve (FFR), which requires the induction of maximal hyperaemia by drug administration, and the ...

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High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases

Cited by 13 publications

References 52 publications

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

<p>Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents</p>

Possible diverse contribution of coronary risk factors to left ventricular systolic and diastolic cavity sizes

A Highly-sensitized Response of B-type Natriuretic Peptide to Cardiac Ischaemia Quantified by Intracoronary Pressure Measurements

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