High serum YKL-40 is a poor prognostic marker in patients with advanced non-small cell lung cancer

Choi, In Keun; Kim, Yeul Hong; Kim, Jun Suk; Seo, Jae Hong

doi:10.3109/02841861003631503

Cited by 28 publications

(28 citation statements)

References 12 publications

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“…In keeping with these diverse sources and stimuli, elevated levels of Chi3l1 have been noted in a wide variety of diseases including infections, arthritis, inflammatory bowel disease, chronic obstructive lung disease, hepatitis, diabetes, atherosclerosis and giant cell arteritis (4–6,8,9). Studies over recent decades have also demonstrated that the levels of circulating Chi3l1 are increased in many malignancies including cancers involving the lung, prostate, colon, rectum, ovary, kidney, breast, glioblastomas and malignant melanoma (5,10,11). In these cases, the levels of Chi3l1 frequently correlate directly with disease progression and inversely with disease free interval and patient survival (10,12–14).…”

Section: Introductionmentioning

confidence: 99%

Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

Herzog

Lee

et al. 2015

Cancer Research

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The prototypic chitinase-like protein Chi3l1 is induced in cancers and portends a poor prognosis, but whether it contributes to cancer progression is unknown. To address this gap in knowledge we investigated the production of Chi3l1 in melanoma lung metastases. We found that Chi3l1 was induced during pulmonary melanoma metastasis and that this induction was regulated by the semaphorin Sema7a, interacting in stimulatory or inhibitory ways with its β1 integrin or Plexin C1 receptors, respectively. In mouse strains with genetic deletions of Chi3l1 or Sema7a, there was a significant reduction in pulmonary metastasis. Notably, antiserum raised against Chi3l1 or Sema7a phenocopied the reduction produced by genetic deletions. Melanoma lung metastasis was also decreased in the absence of IL-13Rα2, a recently identified receptor for Chi3l1, consistent with a key role for Chi3l1 in melanoma spread. We confirmed roles for Sema7a and Chi3l1 in pulmonary metastasis of EMT6 breast cancer cells. Taken together, our studies establish a novel pathway through which Sem7a and its receptors regulate Chi3l1, revealing a host axis involving IL-13Rα2 that plays a critical role in generating a pulmonary microenvironment that is critical to license metastasis.

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Section: Introductionmentioning

confidence: 99%

Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

Herzog

Lee

et al. 2015

Cancer Research

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“…Blood levels of CHi3L1 are negligible under normal physiologic conditions, however, elevated blood levels of CHi3L1 have been found in patients with chronic inflammatory conditions [25] and a wide variety of cancers including colorectal [22,26] , breast [27] , prostate [28] , lung [29,30] , thyroid [31] , endometrial [32] pancreatic [33] hepatocellular [34] , ovarian [35] , gastric cancer [36] , and malignant melanoma [37] . Additionally, for the majority of these malignancies, a correlation has been demonstrated between blood levels of CHi3L1 and a poor prognosis [26,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] . Also, increased expression of CHi3L1 in CRC has been shown to be strongly associated with increased microvascular density [22] .…”

Section: Introductionmentioning

confidence: 99%

Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

Kumara

Gaita

Miyagaki

et al. 2016

WJGO

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AIM:To assess blood chitinase 3-like 1 (CHi3L1) levels for 2 mo after minimally invasive colorectal resection (MICR) for colorectal cancer (CRC). METHODS: CRC patients in an Institutional ReviewBoard approved data/plasma bank who underwent elective MICR for whom preoperative (PreOp), early postoperative (PostOp), and 1 or more late PostOp samples [postoperative day (POD) 7-27] available were included. Plasma CHi3L1 levels (ng/mL) were determined in RESULTS:PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/ mL (n = 80). Significantly elevated (P < 0.001) median plasma levels (ng/mL) over PreOp levels were detected on POD1 (667.7 CI: 495.7, 771.7; n = 79), POD 3 (132.6 CI: 95.5, 173.7; n = 76), 136.9; n = 62), 287.4; n = 22), 137.4; n = 20, P = 0.001).No significant difference in plasma levels were noted on POD27-41.CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.

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“…Increased serum levels of CHI3L1 are associated with disease severity and shorter overall survival in many types of cancers. Given the important impact of CHI3L1 on the development and progression of several types of cancer, several studies have studied the prognostic role of CHI3L1 levels in patients with lung cancer [15][16][17][18][19]. However, the results of from those studies were controversial and the prognostic role of CHI3L1 in lung cancer still remained unclear.…”

Section: Introductionmentioning

confidence: 93%

“…Titles and abstracts screened, a total of 8 independent studies were preliminarily identified and were further assessed by reading full-text [15][16][17][18][19][27][28][29]. After reviewing the full-text, one study [29] was excluded and seven studies were eventually used in the present meta-analysis [15-19, 27, 28].…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients

Wang

Sheng

Yang

et al. 2016

Cell Physiol Biochem

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Background/Aims: The chitinase 3-like 1 (CHI3L1) has an important role in cancer progression, and high CHI3L1 expression is associated with the development and progression of cancers. Previous studies had been controversial with respect to the association between CHI3L1 expression and lung cancer prognosis. Thus, we performed a meta-analysis to investigate the prognostic value of CHI3L1 expression in lung cancer. Methods: We searched Pubmed, Embase, and Wanfang databases to identify eligible studies. Overall survival and disease free survival were collected from included studies. Pooled hazard ratios (HRs) with 95% confidence interval (95%CI) were calculated to estimate the association. Seven studies comprising 911 lung cancer patients were included in this meta-analysis. Results: The results showed high CHI3L1 expression was independently associated with poorer overall survival in lung cancer patients (HR = 1.71, 95%CI 1.24-2.37, P = 0.001). Subgroup analysis by histological type showed that high CHI3L1 expression was independently associated with poorer overall survival in both non small-cell lung cancer patients (HR = 2.23,95%CI 1.43-3.47, P < 0.001) and small-cell lung cancer patients (HR = 1.45, 95%CI 1.06-2.00, P = 0.021). In addition, sensitivity analysis by omitting single study by turns did not change the pooled outcomes obviously. Conclusion: Our results suggest that elevated serum CHI3L1 concentration is an independent prognostic biomarker for poorer survival in lung cancer patients.

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High serum YKL-40 is a poor prognostic marker in patients with advanced non-small cell lung cancer

Cited by 28 publications

References 12 publications

Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

Role of Chitinase 3–like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients

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