High sodium intake adversely affects oxidative-inflammatory response, cardiac remodelling and mortality after myocardial infarction

Costa, Ana Paula; Paula, Rafaela C.S. de; Carvalho, Guilherme; Araújo, Juliana Pelissoni; Andrade, Joseilze Santos de; Almeida, Osório L.R.; Faria, Eliana Cotta de; Freitas, Wladimir M.; Coelho, Otávio Rizzi; Ramires, José Antônio Franchini; Silva, José C. Quinaglia e; Sposito, Andrei C.

doi:10.1016/j.atherosclerosis.2012.02.037

Cited by 25 publications

(19 citation statements)

References 26 publications

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“…The imbalance between ROS levels produced during metabolism and eliminated by the antioxidant system is termed “ oxidative stress ”. This oxidative stress has major clinical implications as it contributes to the pathology of myocardial infarction as shown in both experimental 3 , 8 and clinical patients after MI 9 . There is a strong association between the oxidative stress, inflammation, development of adverse cardiac remodeling 4 , 5 and heart failure after MI 10 .…”

Section: Introductionmentioning

confidence: 99%

Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction

Bezerra

França

Rocha

et al. 2017

Sci Rep

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We previously reported that cholinergic stimulation with pyridostigmine (PY) induces anti-inflammatory cell recruitment soon after myocardial infarction (MI). In this study, we evaluated the anti-inflammatory effects of PY during the proliferative phase of cardiac repair by analyzing the infiltration of macrophages, Treg lymphocytes, oxidative stress and inflammatory cytokines. Wistar rats underwent control sham surgery or ligation of the left coronary artery and were randomly allocated to remain untreated (untreated infarcted group, I) or to receive PY (30 mg·kg(−1)·day(−1)) in the supplied water (infarcted treated group, I + PY). Blood pressure and heart rate variability were registered at day 5 post-MI. The animals were euthanized 7 days after thoracotomy, when the hearts were removed and processed for immunohistochemistry (CD68, CD206, FOXP3), cytokines (IL-1β, IL-6, IL-10, TNF-α) and oxidative stress (superoxide dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation). PY treatment increased parasympathetic modulation, M2 macrophages and the anti-oxidant enzyme activity but reduced protein oxidation (carbonyls) and the concentration of IL-1β, IL-6, TNF-α and IL-10. Cholinergic stimulation induces parasympathetic neuro-immune modulation and anti-inflammatory cell enrollment as well as prevents oxidative stress and cytokine production after MI.

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Section: Introductionmentioning

confidence: 99%

Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction

Bezerra

França

Rocha

et al. 2017

Sci Rep

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“…[18][19][20] Overall, 22 studies did not meet all of the methodological criteria. Of those, 11 showed a health detriment, [21][22][23][24][25][26][27][28][29][30][31] four found a health benefit, [32][33][34][35] and seven had unclear effects of increasing dietary sodium. [36][37][38][39][40][41][42] There were no significant differences in the distribution of health outcomes for studies that did not meet all criteria compared with what would have been expected by chance ( Figure B, P = .42).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies that examined hard outcomes did not meet all quality criteria: four were associated with a health benefit, [32][33][34][35] four were associated with a health detriment, [28][29][30][31] and three had unclear effects with increasing dietary sodium. [36][37][38] Two studies that were associated with a health benefit from increasing dietary sodium met all except conflict of interest quality criteria.…”

Section: Resultsmentioning

confidence: 99%

Impact of quality of research on patient outcomes in the Institute of Medicine 2013 report on dietary sodium

Lucko

Doktorchik

Campbell

2018

J of Clinical Hypertension

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Assessment of Evidence" found inconsistent evidence of health benefit with dietary sodium intake <2300 mg/d. Different studies reported benefit and harm of population dietary intake <2300 mg/d. The Institute of Medicine committee, however, did not assess whether the methodology used in each of the studies was appropriate to examine dietary sodium and health outcomes. This review investigates the association of methodological rigor and outcomes of studies in the Institute of Medicine report. For the 13 studies that met all methodological criteria, nine found a detrimental impact of high sodium consumption on health, one found a health benefit, and in three the effect was unclear (P = .068). For the 22 studies that failed to meet all criteria, 11 showed a detrimental impact, four a health benefit, and seven had unclear effects from increasing dietary sodium (P = .42).

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“…A food frequency intake questionnaire (FFQ) previously validated in a Brazilian Population [11] was applied for assessment of zinc intake. Participants reported the intake of foods consumed during the previous month, which were clustered in 62 items, and the use of nutritional supplements.…”

Section: Methodsmentioning

confidence: 99%

Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

et al. 2014

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BackgroundReduced zinc intake has been related to atherogenesis and arteriosclerosis. We verified this assumption in very old individuals, which are particularly prone to both zinc deficiency and structural and functional changes in the arterial wall.MethodsSubjects (n = 201, 80–102 years) with uneventful cardiovascular history and who were not in use of anti-inflammatory treatments in the last 30-days were enrolled. Daily intake of zinc, lipid profile, plasma C-reactive protein (CRP), plasma zinc, flow-mediated dilation (FMD), carotid ultrasonography and cardiac computed tomography were obtained. Young's Elastic Modulus, Stiffness Index and Artery Compliance were calculated.ResultsThere was no significant difference in clinical or laboratorial data between subjects grouped according to plasma zinc tertile, except for CRP (p = 0.01) and blood leukocytes (p = 0.002), of which levels were higher in the upper tertiles. The average daily intake of zinc was not significantly correlated with zinc or CRP plasma levels.The plasma zinc/zinc intake ratio was inversely correlated with plasma CRP levels (− 0.18; p = 0.01). There was no significant difference between the plasma zinc tertiles and FMD, carotid intima–media thickness, coronary calcium score, carotid plaque presence, remodeled noncalcified coronary plaques, or low-attenuation noncalcified coronary plaques.ConclusionAlthough plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall.General significanceIn the very elderly plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis or atherosclerotic burden at coronary or carotid arteries.

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High sodium intake adversely affects oxidative-inflammatory response, cardiac remodelling and mortality after myocardial infarction

Abstract: Excessive sodium intake increases oxidative stress, inflammatory response, myocardial stretching and dilatation, and short and long-term mortality after STEMI.

Cited by 25 publications

References 26 publications

Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction

Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction

Impact of quality of research on patient outcomes in the Institute of Medicine 2013 report on dietary sodium

Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly

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