High Specific Absorption Rate and Transverse Relaxivity Effects in Manganese Ferrite Nanoparticles Obtained by an Electrochemical Route

Abstract

Superparamagnetic iron oxide-based nanoparticles (SPIONS) have attracted an enormous amount of attention for their potential use in biomedical applications, due to their good biocompatibility and low toxicity. The current study considers citric acidconjugated manganese ferrite and its synergy to be used in MRI and in hyperthermia treatment, thus showing theragnostic applications. High colloidal stability was obtained with this functionalization. SPIONS with superparamagnetic behavior of crystal sizes of approximately 20 nm were obtained via an electrochemical synthesis method. One of the highest specific absorption rate (SAR) values was achieved in this work (1661 W g −1 ), under a magnetic field of 30 mT at 717 kHz frequency, compared with other magnetic ferrites in the literature. These nanoparticles dissipate heat through Neél relaxation and, together with the high SAR value obtained, indicate an excellent material for hyperthermia treatment of cancer. In addition, these nanoparticles exhibit transverse relaxivity behavior, with an r 2 value of 394 mM −1 s −1 , i.e., at least two times higher than the value of a commercial magnetic contrast agent based on iron oxides. Finally, no toxicity effects of these nanoparticles are evidenced; as a result, these nanoparticles are appropriate for in vivo application.

Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe3O4 core–shell nanoparticles

“…Unlike gold nanoparticles which possess a mechanical weakness in photothermal process, most of the magnetic nanoparticles do not show obvious morphology changed during magnetic hyperthermia experiments. In recent years, many kinds of research have been made to prepare magnetic nanoparticles with high magnetic saturation value [17,18] for more effective heat generation [19][20][21].…”

Electrocatalytic Activity of Nanohybrids Based on Carbon Nanomaterials and MFe2O4 (M=Co, Mn) towards the Reduction of Hydrogen Peroxide

“…Synthesis of MFe 2 O 4 : Cobalt (CoFe 2 O 4 ) and manganese (MnFe 2 O 4 ) ferrite nanoparticles were prepared according to . Briefly, two anodes, one of iron (2 cm 2 ) and the other of cobalt or manganese (2 cm 2 ) parallel positioned between them, and a cylindrical iron counter electrode (120 cm 2 ) were placed in a 0.040 M tetrabuthyl ammonium bromide aqueous solutions.…”

Towards the design of contrast-enhanced agents: systematic Ga3+ doping on magnetite nanoparticles

“…12,13 In the case of dark contrast, the enhancement of T 2 relaxivity has been exploited not only by the strategy of doping but also by controlling morphologies and compositions. [14][15][16][17] Although MRI provides anatomical details with high spatial resolution, in the case of exploring cancer staging, nuclear imaging techniques such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT) are also applied due to high spatial resolution. In this way, the incorporation of 68 Ga in magnetite allows the development of multimodal nanosystems for PET/MRI imaging.…”