High specific activity tritiation of various methylated histamine analogues

Tritium NMR: A compilation of data and a practical guide

“…Reproduced with minor editing privilege from Filer et al [97] with the permission of Elsevier F I G U R E 6 6 Proton decoupled tritium NMR spectrum of [N-methyl-3 H] N-methylhistamine recorded in D 2 O at 320 MHz. Reproduced with minor editing privilege from Filer et al [96] with the permission of Springer Nature pirole, one of the dopamine D2 receptor agonists, provided additional evidence of the hindered internal rotation resulting in the methylene group separation; see Figure 69.…”

“…Filer and coworkers [ 96 ] performed a high specific activity tritiation of various methylated histamine analogues including ( R )‐[5‐ 3 H] alpha‐methylhistamine, [ N ‐methyl‐ 3 H] N ‐methylhistamine, and [ N , N dimethyl‐ 3 H] N , N ‐dimethylhistamine. Those species are known of their key role in such diverse areas as cell proliferation, embryonic development, wound healing as well as brain, cardiovascular and endocrine function.…”

“…Proton decoupled tritium NMR spectrum of [ N ‐methyl‐ 3 H] N ‐methylhistamine recorded in D 2 O at 320 MHz. Reproduced with minor editing privilege from Filer et al [ 96 ] with the permission of Springer Nature…”