High-speed adaptive optics for imaging of the living human eye

Yu, Yongxin; Zhang, Tianjiao; Meadway, Alexander; Wang, Xiaolin; Zhang, Yuhua

doi:10.1364/oe.23.023035

Cited by 41 publications

(24 citation statements)

References 51 publications

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“…3 , right), suggesting that a loop rate between 10 and 40 corrections per second would cancel them (assuming typical latencies and gain) and achieve closed-loop performance near the diffraction limit (Strehl ratio > 0.8). 30 Later, aberration bandwidths of 30 Hz 31 – 33 or higher 34 were observed, suggesting that substantially higher rates may be beneficial. A recent study using a rate of 110 corrections per second demonstrated the predicted improvements in resolution and contrast.…”

Section: Improving Transverse Resolution With Adaptive Opticsmentioning

confidence: 98%

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A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

Jonnal

Kocaoglu

Zawadzki

et al. 2016

Invest. Ophthalmol. Vis. Sci.

140

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PurposeOptical coherence tomography (OCT) has enabled “virtual biopsy” of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to combine the microscopic transverse resolution of AO with the microscopic axial resolution of OCT, building AO-OCT systems with the highest three-dimensional resolution of any existing retinal imaging modality.MethodsWe surveyed the literature to identify the most influential antecedent work, important milestones in the development of AO-OCT technology, its applications that have yielded new knowledge, research areas into which it may productively expand, and nascent applications that have the potential to grow.ResultsInitial efforts focused on demonstrating three-dimensional resolution. Since then, many improvements have been made in resolution and speed, as well as other enhancements of acquisition and postprocessing techniques. Progress on these fronts has produced numerous discoveries about the anatomy, function, and optical properties of the retina.ConclusionsAdaptive optics OCT continues to evolve technically and to contribute to our basic and clinical knowledge of the retina. Due to its capacity to reveal cellular and microscopic detail invisible to clinical OCT systems, it is an ideal companion to those instruments and has the demonstrable potential to produce images that can guide the interpretation of clinical findings.

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Section: Improving Transverse Resolution With Adaptive Opticsmentioning

confidence: 98%

“…A recent study using a rate of 110 corrections per second demonstrated the predicted improvements in resolution and contrast. 33 …”

Section: Improving Transverse Resolution With Adaptive Opticsmentioning

confidence: 99%

A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

Jonnal

Kocaoglu

Zawadzki

et al. 2016

Invest. Ophthalmol. Vis. Sci.

140

View full text Add to dashboard Cite

show abstract

“…Across all of these applications, there is a distinct benefit to scanning at high speeds as it translates to higher throughput for optical targeting and actuation, for the acquisition of sensing and recording data, and for the processing of materials into desired products. 2,7 Despite the ubiquity of optical scanning across disciplines, specific embodiments of 3D scanning tools vary widely and in accordance with the diversity in performance needs across applications. Two important specifications driving this variety are the lateral (XY) and axial (Z) dimensions of both the whole volume and elemental pattern of interest.…”

Section: D Optical Scanningmentioning

confidence: 99%

Design framework for high-speed 3D scanning tools and development of an axial focusing micromirror-based array

Ersumo

Yalçın

Antipa

et al. 2020

MOEMS and Miniaturized Systems XIX

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Rapid 3D optical scanning of points or patterned light is widely employed across applications in microscopy, material processing, adaptive optics and surveying. Despite this broadness in applicability, embodiments of 3D scanning tools may vary considerably as a result of the specific performance needs of each application. We present here a micromirror arraybased modular framework for the systemic design of such high-speed scanning tools. Our framework combines a semicustom commercial fabrication process with a comprehensive simulation pipeline in order to optimally reconfigure pixel wiring schemes across specific applications for the efficient allocation of available degrees of freedom. As a demonstration of this framework and to address existing bottlenecks in axial focusing, we produced a 32-ring concentric micromirror array capable of performing random-access focusing for wavelengths of up to 1040 nm at a response rate of 8.75 kHz. By partitioning the rings into electrostatically driven piston-mode pixels, we are able to operate the array through simple openloop 30 V drive, minimizing insertion complexity, and to ensure stable operation by preventing torsional failure and curling from stress. Furthermore, by taking advantage of phase-wrapping and the 32 degrees of freedom afforded by the number of independently addressable rings, we achieve good axial resolvability across the tool's operating range with an axial fullwidth-half-maximum to range ratio of 3.5% as well as the ability to address focus depth-dependent aberrations resulting from the optical system or sample under study.

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“…First, wavefront sensing and adaptive optics can improve the spot size of the beam on the retina and account for aberrations in the eye. Such systems have been reported for human retinal OCT and scanning laser ophthalmoscope systems [27,28] and for murine retinal OCT systems [29,30]. Classically, these OCT systems employ a wavefront sensor (either with a Shack-Hartmann wavefront sensor or computationally).…”

Section: Corneal Contactmentioning

confidence: 99%

Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography

et al. 2018

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Optical coherence tomography (OCT), an optical imaging approach enabling cross-sectional analysis of turbid samples, is routinely used for retinal imaging in human and animal models of diseases affecting the retina. Scattering angle resolved (SAR-)OCT has previously been demonstrated as offering additional contrast in human studies, but no SAR-OCT system has been reported in detail for imaging the retinas of mice. An optical model of a mouse eye was designed and extended for validity at wavelengths of light around 1310 nm; this model was then utilized to develop a SAR-OCT design for murine retinal imaging. A Monte Carlo technique simulates light scattering from the retina, and the simulation results are confirmed with SAR-OCT images. Various images from the SAR-OCT system are presented and utility of the system is described. SAR-OCT is demonstrated as a viable and robust imaging platform to extend utility of retinal OCT imaging by incorporating scattering data into investigative ophthalmologic analysis.

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High-speed adaptive optics for imaging of the living human eye

Cited by 41 publications

References 51 publications

A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

Design framework for high-speed 3D scanning tools and development of an axial focusing micromirror-based array

Design Considerations for Murine Retinal Imaging Using Scattering Angle Resolved Optical Coherence Tomography

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