High-speed analysis of residual solvents by flow-modulation gas chromatography

Use of Mass Spectrometry Methods as a Strategy for Detection and Determination of Residual Solvents in Pharmaceutical Products

“…Over the last years, several GC methods for monitoring residual solvents in pharmaceutical samples have been reported in the literature. [4][5][6][7][8][9][10][11][12][13] Headspace (HS) generation 4,5,[9][10][11][12][13] is the preferred sampling technique over others, such as headspace-solid-phase microextraction (SPME). 6,7 In headspace analysis, a liquid or solid sample is placed in a sealed vial for equilibration at elevated temperature.…”

“…One of the most important applications of GC in the pharmaceutical industry is the analysis of residual solvents along the various stages of drug development. Over the last years, several GC methods for monitoring residual solvents in pharmaceutical samples have been reported in the literature. − Headspace (HS) generation 4,5,9-13 is the preferred sampling technique over others, such as headspace-solid-phase microextraction (SPME). , …”