High-speed footage shows transient ultrasonic nucleation of different hydrophobic particles in suspension

Postema, Michiel; Matsumoto, Ryonosuke; Shimizu, Ri-ichiro; Poortinga, Albert T.; Kudo, Nobuki

doi:10.35848/1347-4065/ab7f19

Cited by 10 publications

(13 citation statements)

References 18 publications

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“…The high attenuation of antibubbles may be caused by the endoskeleton that may add a viscous behavior to the inner gas phase. Alternatively, the hydrophobic ZnO particles forming the endoskeleton were observed to be surrounded by a thin gaseous layer 67 . These tiny air pockets are acoustically active at low acoustic amplitudes, absorbing acoustic energy, and cavitating 67 …”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, the hydrophobic ZnO particles forming the endoskeleton were observed to be surrounded by a thin gaseous layer. 67 These tiny air pockets are acoustically active at low acoustic amplitudes, absorbing acoustic energy, and cavitating. 67 The attenuation measurement at 3.5 MHz, conducted with a Verasonics probe in echo-mode, yielded somewhat lower attenuation values for all UCAs than the through-transmission measurement with piston transducers.However,both measurements point out the same qualitative differences among UCAs.…”

Section: Discussionmentioning

confidence: 99%

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Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

et al. 2021

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An antibubble is an encapsulated gas bubble with an incompressible inclusion inside the gas phase. Current-generation ultrasound contrast agents are bubble-based: they contain encapsulated gas bubbles with no inclusions. The objective of this work is to determine the linear and nonlinear responses of an antibubble contrast agent in comparison to two bubble-based ultrasound contrast agents, that is, reference bubbles and SonoVue TM . Methods: Side scatter and attenuation of the three contrast agents were measured, using single-element ultrasound transducers, operating at 1, 2.25, and 3.5 MHz. The scatter measurements were performed at acoustic pressures of 200 and 300 kPa for 1 MHz, 300 kPa, and 450 kPa for 2.25 MHz, and 370 and 560 kPa for 3.5 MHz. Attenuation measurements were conducted at pressures of 13, 55, and 50 kPa for 1, 2.25, and 3.5 MHz, respectively. In addition, a dynamic contrast-enhanced ultrasound measurement was performed, imaging the contrast agent flow through a vascular phantom with a commercial diagnostic linear array probe. Results: Antibubbles generated equivalent or stronger harmonic signal, compared to bubble-based ultrasound contrast agents. The second harmonic sidescatter amplitude of the antibubble agent was up to 3 dB greater than that of reference bubble agent and up to 4 dB greater than that of SonoVue TM at the estimated concentration of 8 × 10 4 bubbles/mL. For ultrasound with a center transmit frequency of 1 MHz, the attenuation coefficient of the antibubble agent was 8.7 dB/cm, whereas the attenuation coefficient of the reference agent was 7.7 and 0.3 dB/cm for SonoVue TM . At 2.25 MHz, the attenuation coefficients were 9.7, 3.0, and 0.6 dB/cm, respectively. For 3.5 MHz, they were 4.4, 1.8, and 1.0 dB/cm, respectively. A dynamic contrast-enhanced ultrasound recording showed the nonlinear signal of the antibubble agent to be 31% greater than for reference bubbles and 23% lower than SonoVue TM at a high concentration of 2 × 10 6 bubbles/mL. Conclusion: Endoskeletal antibubbles generate comparable or greater higher harmonics than reference bubbles and SonoVue TM . As a result, antibubbles with liquid therapeutic agents inside the gas phase have high potential to become a traceable therapeutic agent. K E Y W O R D S harmonic imaging, linear attenuation, nonlinear scattering, pickering-stabilised bubbles, ultrasound contrast agentThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

et al. 2021

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“…Some of these particles have been observed to lose their surrounding voids whilst oscillating. Once dehydrophobised, they appeared to remain inactive in an ultrasound field [19]. Consequently, we speculate, that the state of hydrophobicity must influence the thermal damping of ultrasound propagating through the fluid.…”

Section: Introductionmentioning

confidence: 86%

“…Black tattoo ink comprises carbon black nanoparticles [17,18]. As carbon black nanoparticles demonstrate transient dynamic activity in an ultrasound field [19], we hypothesize that black tattoo ink exhibits similar behavior. The purpose of this study is to investigate transient and steady-state behavior of black tattoo ink under sonication.…”

Section: Introductionmentioning

confidence: 95%

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On the attenuation of ultrasound by pure black tattoo ink

et al. 2021

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Black tattoo ink comprises hydrophobic carbon black nanoparticles. We hypothesized that black tattoo ink demonstrates transient dynamic activity in an ultrasound field. Brightness-mode sonography was performed on cylindrical receptacles of different bore diameters, filled with black tattoo ink, water, saline, or air, using pulsed ultrasound with center frequencies of 13 MHz and 5 MHz.The scattering from black ink itself lasted less than ten minutes. At 13-MHz sonication, a transient drop in sound speed was observed, as well as a transient lessening of scattering from distal phantom tissue. The linear acoustic attenuation coefficient of pure black ink was measured to be 0.15±0.01 dB cm −1 MHz −1 , equal to whole blood.Low-intensity ultrasonic tattoo removal would be of interest as an alternative to techniques that damage surrounding tissue.

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Release of liposomally formulated near-infrared fluorescent probes included in giant cluster vesicles by ultrasound irradiation

et al. 2023

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High-speed footage shows transient ultrasonic nucleation of different hydrophobic particles in suspension

Cited by 10 publications

References 18 publications

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

On the attenuation of ultrasound by pure black tattoo ink

Release of liposomally formulated near-infrared fluorescent probes included in giant cluster vesicles by ultrasound irradiation

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