With the rapid development of the Internet, the security of network multimedia data has attracted increasingly more attention. The moving target defense (MTD) and cyber mimic defense (CMD) approaches provide a new way to solve this problem. To enhance the security of network multimedia data, this paper proposes a mimic encryption box for network multimedia data security. The mimic encryption box can directly access the network where the multimedia device is located, automatically complete the negotiation, provide safe and convenient encryption services, and effectively prevent network attacks. According to the principles of dynamization, diversification, and randomization, the mimic encryption box uses a reconfigurable encryption algorithm to encrypt network data and uses IP address hopping, port number hopping, protocol camouflage, and network channel change to increase the attack threshold. Second, the mimic encryption box has a built-in pseudorandom number generator and key management system, which can generate an initial random key and update the key with the hash value of the data packet to achieve “one packet, one key.” Finally, through the cooperation of the ARM and the FPGA, an access control list can be used to filter illegal data and monitor the working status of the system in real time. If an abnormality is found, the feedback reconstruction mechanism is used to “clean” the FPGA to make it work normally again. The experimental results and analysis show that the mimic encryption box designed in this paper has high network encryption performance and can effectively prevent data leakage. At the same time, it provides a mimic security defense mechanism at multiple levels, which can effectively resist a variety of network attacks and has high security.