High-speed low-noise optical respiratory monitoring for spot scanning proton therapy

Belikhin, M. A.; Pryanichnikov, A. A.; Балакин, В.Е.; Shemyakov, A. E.; Zhogolev, P.; Chernyaev, A. P.

doi:10.1016/j.ejmp.2023.102612

Physica Medica

2023

DOI: 10.1016/j.ejmp.2023.102612

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High-speed low-noise optical respiratory monitoring for spot scanning proton therapy

M. A. Belikhin

A. A. Pryanichnikov

В.Е. Балакин³

et al.

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2024

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Cited by 2 publications

References 49 publications

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High‐speed bioimpedance‐based gating system for radiotherapy: Prototype and proof of principle

Belikhin,

Chernyaev,

Pryanichnikov

2024

J Applied Clin Med Phys

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PurposeTo investigate a novel bioimpedance‐based respiratory gating system (BRGS) designed for external beam radiotherapy and to evaluate its technical characteristics in comparison with existing similar systems.Materials and methodsThe BRGS was tested on three healthy volunteers in free breathing and breath‐hold patterns under laboratory conditions. Its parameters, including the time delay (TD) between the actual impedance change and the gating signal, temperature drift, root mean square (RMS) noise, and signal‐to‐noise ratio (SNR), were measured and analyzed.ResultsThe gate‐on TD and the gate‐off TD were found to be 9.0 ± 2.0 ms [mean ± standard deviation (M ± SD)] and 7.2 ± 1.3 ms, respectively. The temperature drift of the BRGS output signal was 0.02 Ω after 30 min of operation. RMS noise averaged 0.14 ± 0.05 Ω (M ± SD) for all subjects and varied from 0.08 to 0.20 Ω with repeated measurements. A significant difference in SNR (p < 0.001) was observed between subjects, ranging from 4 to 15.ConclusionThe evaluated bioimpedance‐based gating system showed a high performance in real‐time respiratory monitoring and may potentially be used as an external surrogate guidance for respiratory‐gated external beam radiotherapy. Direct comparison with commercially available systems, 4D correlation studies, and expansion of the patient sample are goals for future preclinical studies.

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High‐speed bioimpedance‐based gating system for radiotherapy: Prototype and proof of principle

Belikhin,

Chernyaev,

Pryanichnikov

2024

J Applied Clin Med Phys

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Interplay Effect in Spot-Scanning Proton Therapy with Rescanning, Breath Holding, and Gating: A Phantom Study

Belikhin,

Shemyakov,

Ivanov

et al. 2024

Applied Sciences

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The interplay effect is a challenge when using proton scanning beams for the treatment of thoracic and abdominal cancers. The aim of this study was to evaluate the facility-specific interplay effect in terms of dose distortion and irradiation time for different beam delivery modalities, including free breathing (FB) irradiation, rescanning, deep inspiration breath-hold (DIBH), and respiratory gating. This study was carried out at a synchrotron-based facility with spot-scanning beam delivery. A motion phantom with a radiochromic film was used to measure dose distributions. Regular and irregular motion patterns were studied. Dose homogeneity and the gamma index were calculated to quantify the interplay effect. The interplay effect significantly decreased the homogeneity and gamma passing rate by 12% and 46%, respectively, when FB irradiation without motion mitigation was used for 20 mm peak-to-peak motion. Rescanning and DIBH partially mitigated the distortions but doubled the irradiation time, while gating provided the superior dose distribution with only a 25% increase in time compared to FB irradiation without mitigation. The interplay effect was a function of motion amplitude and varied with the beam delivery modality. Gating may be a more preferable technique for the synchrotron-based facility in terms of minimizing dose distortion and treatment time.

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High-speed low-noise optical respiratory monitoring for spot scanning proton therapy

Cited by 2 publications

References 49 publications

High‐speed bioimpedance‐based gating system for radiotherapy: Prototype and proof of principle

High‐speed bioimpedance‐based gating system for radiotherapy: Prototype and proof of principle

Interplay Effect in Spot-Scanning Proton Therapy with Rescanning, Breath Holding, and Gating: A Phantom Study

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