Optical Tomography and Spectroscopy of Tissue XV 2023
DOI: 10.1117/12.2651676
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High-speed spatial parameter recovery using multi-distance frequency-domain diffuse optical spectroscopy

Abstract: Frequency domain (FD) diffuse optical spectroscopy (DOS) can be used to recover absolute optical properties of biological tissue, providing valuable clinical feedback, including in diagnosis and monitoring of breast tumours. In this study, tomographic (3D) and topographic (2D) techniques for spatially-varying optical parameter recovery are presented, based on a multi-distance, handheld DOS probe. Processing pipelines and reconstruction quality are discussed and quantitatively compared, demonstrating the trade-… Show more

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“…The μs parameter is additionally indicative of tissue microstructure and can provide an additional biomarker for distinguishing malignant versus benign breast tumors 11 , 12 . Clinical adoption of frequency-domain diffuse optical tomography (FD-DOT) has so far been limited due to the size and complexity of the systems; however, recent hardware developments have significantly improved miniaturization, accuracy, and usability, 9 enabling accurate, high-speed, and depth-sensitive broadband FD-NIRS measurements at multiple modulation frequencies with a hand-held probe 13 and thereby high-speed two-dimensional (2D) imaging of bulk optical properties 14 …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The μs parameter is additionally indicative of tissue microstructure and can provide an additional biomarker for distinguishing malignant versus benign breast tumors 11 , 12 . Clinical adoption of frequency-domain diffuse optical tomography (FD-DOT) has so far been limited due to the size and complexity of the systems; however, recent hardware developments have significantly improved miniaturization, accuracy, and usability, 9 enabling accurate, high-speed, and depth-sensitive broadband FD-NIRS measurements at multiple modulation frequencies with a hand-held probe 13 and thereby high-speed two-dimensional (2D) imaging of bulk optical properties 14 …”
Section: Introductionmentioning
confidence: 99%
“…11,12 Clinical adoption of frequency-domain diffuse optical tomography (FD-DOT) has so far been limited due to the size and complexity of the systems; however, recent hardware developments have significantly improved miniaturization, accuracy, and usability, 9 enabling accurate, high-speed, and depth-sensitive broadband FD-NIRS measurements at multiple modulation frequencies with a hand-held probe 13 and thereby high-speed twodimensional (2D) imaging of bulk optical properties. 14 Reconstructing three dimensional (3D) as opposed to 2D images using DOT provides important additional information regarding the size, shape, and position of features such as tumors. This approach is ill-posed as the number of reconstruction voxels is generally far greater than the number of available measurements.…”
mentioning
confidence: 99%