High-speed video investigation of jet dynamics from narrow orifices for needle-free injection

Moradiafrapoli, M.; Marston, Jeremy

doi:10.1016/j.cherd.2016.10.023

Cited by 40 publications

(30 citation statements)

References 42 publications

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“…This result is consistent with other studies such as [9] where the authors mentioned that the highest impact of the waterjet can be achieved at the very beginning when the waterjet hits soft tissue, and after that the water starts to flow radially that results in decrease of the impact of the jet. This result is also consistent with the result of the DOC vs. time presented by Morad et al [34] in which the slope of the DOC vs. time decreased after about 30 (s), and also with the results of depth of cut vs. time presented in [35], [52], and [57]. In other words, the e↵ective velocity of the waterjet in soft medium is less than the velocity of waterjet coming out of the nozzle.…”

Section: Strain Gaugessupporting

confidence: 92%

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Predictive mechanics-based model for depth of cut (DOC) of waterjet in soft tissue for waterjet-assisted medical applications

Babaiasl

Boccelli

Chen

et al. 2020

Med Biol Eng Comput

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Section: Strain Gaugessupporting

confidence: 92%

“…Predicting DOC of liquid in soft tissue is also important from needle-free drug injections point of view [32,35]. In these devices, the desired drug is ejected from a nozzle of diameter in the range of 30 to 560 µm at a velocity of ⇡ 100 m s [47].…”

Section: Introductionmentioning

confidence: 99%

Predictive mechanics-based model for depth of cut (DOC) of waterjet in soft tissue for waterjet-assisted medical applications

Babaiasl

Boccelli

Chen

et al. 2020

Med Biol Eng Comput

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“…The focus is now shifting toward user-friendly disposable cartridge jet injectors for single-dose devices eliminating the risk of cross-contamination. 23 Future study should expand on tailored parameters pertaining to traditional and new indications of NFII to insure a safe and effective outcome.…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, future developments should focus on disposable cartridges for single-dose devices. 23 …”

Section: Risks and Challengesmentioning

confidence: 99%

Current trends in needle-free jet injection: an update

Barolet¹,

Benohanian²

2018

CCID

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BackgroundJet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin.ObjectiveThe aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use.MethodsA review of the literature was performed with no limits placed on publication date.ResultsNeedleless injectors not only reduce pain during drug delivery but also confine the drug more evenly in the dermis. Understanding skin properties of the injection site is a key factor to obtain optimal results as well as setting the right parameters of the jet injector. Until the advent of disposable jet injectors/cartridges, autoclaving of the injector remains the only reliable method to eliminate the risk of infection. Needle-free intradermal injection using corticosteroids and/or local anesthetics is well documented with promising indications being developed.LimitationsLimitations of the review include low-quality evidence, small sample sizes, varying treatment parameters, and publication bias.ConclusionNew developments may help reconsider the use of jet injection technology. Future studies should focus on measurable optimized parameters to insure a safe and effective outcome.

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“…A large scatter in the data is observed, which we attribute to the initial condition in the nozzle and the walls, e.g. the presence of water droplets from a previous jet ejection [64]. The jet speed is observed to increase under two specific conditions.…”

Section: Experimental and Numerical Results Comparison Of Jet Regimesmentioning

confidence: 77%

Microfluidics control the ballistic energy of thermocavitation liquid jets for needle-free injections

Galvez

Fraters

Offerhaus

et al. 2020

Journal of Applied Physics

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Illuminating a water solution with a focused continuous wave laser produces a strong local heating of the liquid that leads to the nucleation of bubbles, also known as thermocavitation. During the growth of the bubble, the surrounding liquid is expelled from the constraining microfluidic channel through a nozzle, creating a jet. The characteristics of the resulting liquid jet was imaged using ultra-fast imaging techniques. Here, we provide a phenomenological description of the jet shapes and velocities, and compare them with a Boundary Integral numerical model. We define the parameter regime, varying jet speed, taper geometry and liquid volume, for optimal printing, injection and spray applications. These results are important for the design of energy-efficient needle-free jet injectors based on microfluidic thermocavitation. arXiv:2003.00934v1 [physics.flu-dyn]

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High-speed video investigation of jet dynamics from narrow orifices for needle-free injection

Cited by 40 publications

References 42 publications

Predictive mechanics-based model for depth of cut (DOC) of waterjet in soft tissue for waterjet-assisted medical applications

Predictive mechanics-based model for depth of cut (DOC) of waterjet in soft tissue for waterjet-assisted medical applications

Current trends in needle-free jet injection: an update

Microfluidics control the ballistic energy of thermocavitation liquid jets for needle-free injections

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