High-speed videolaryngoscopy in early glottic carcinoma patients following transoral CO2 LASER cordectomy

Gandhi, Sachin; Bhatta, Subash; Ganesuni, Dushyanth; Ghanpur, Asheesh Dora; Saindani, Shraddha Jayant

doi:10.1007/s00405-020-06433-6

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…To the best of the authors' knowledge, the previous works by Shock et al, 4 Strohl et al, 6 and Lever et al 7 constitute the only investigations related to parameters of the human LAR other than its threshold stimulation intensity and onset latency. The benefits of high‐speed videolaryngoscopy with respect to laryngostroboscopy, particularly in the field of aperiodic events, have been discussed in numerous works 14–19 . In the context of the present work, the high temporal resolution enabled the detailed assessment of the VF kinematics during the LAR adduction phase.…”

Section: Discussionmentioning

confidence: 91%

“…The benefits of high-speed videolaryngoscopy with respect to laryngostroboscopy, particularly in the field of aperiodic events, have been discussed in numerous works. [14][15][16][17][18][19] In the context of the present work, the high temporal resolution enabled the detailed assessment of the VF kinematics during the LAR adduction phase. At present, high-speed laryngoscopes are scarce and can mainly be found at tertiary care centers.…”

Section: Discussionmentioning

confidence: 98%

“…2,12 The method relies on high-speed laryngoscopy to optically register the droplet-induced reflex response at a high temporal resolution. 13 This emerging imaging modality has shown promising results in the assessment of aperiodic vocal fold (VF) motion [14][15][16][17][18][19] ; in the specific case of the LAR, it enables the precise optical quantification of the reflex onset latency and the detailed study of the VF kinematics.…”

Section: Introductionmentioning

confidence: 99%

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Computational Analysis of the Droplet‐Stimulated Laryngeal Adductor Reflex in High‐Speed Sequences

et al. 2022

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Objectives/Hypothesis The laryngeal adductor reflex (LAR) is an important protective mechanism of the airways. Its physiology is still not completely understood. The available methods for LAR evaluation offer limited reproducibility and/or rely on subjective interpretation. A new approach, termed Microdroplet Impulse Testing of the LAR (MIT‐LAR), was recently introduced. Here, the LAR is elicited by a droplet and a laryngoscopic high‐speed recording is acquired simultaneously. In the present work, image‐processing algorithms for autonomous MIT‐LAR sequence analysis were developed. This allowed the automated approximation of kinematic LAR parameters in humans. Study Design Development and testing of computational methods. Methods Computational image processing enabled the autonomous estimation of the glottal area, the glottal angle, and the vocal fold edge distance in MIT‐LAR sequences. A suitable analytical representation of these glottal parameters allowed the extraction of seven relevant LAR parameters. The obtained values were compared to the literature. Results A generalized logistic function showed the highest average goodness of fit among four different analytical approaches for each of the glottal parameters. Autonomous sequence analysis yielded bilateral LAR response latencies of (229 ± 116) ms and (182 ± 60) ms for cases of complete and incomplete glottal closure, respectively. The initial/average/maximum angular vocal fold adduction velocity was estimated at (157 ± 115) °s−1/(891 ± 516) °s−1/(929 ± 583) °s−1 and (88 ± 53) °s−1/(421 ± 221) °s−1/(520 ± 238) °s−1 for complete and incomplete glottal closure, respectively. Conclusion The automated extraction of LAR parameters from laryngoscopic high‐speed sequences can potentially increase the objectiveness of optical LAR characterization and reduce the associated workload. The proposed methods may thus be helpful for future research on this vital reflex. Level of Evidence NA Laryngoscope, 132:2412–2419, 2022

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Computational Analysis of the Droplet‐Stimulated Laryngeal Adductor Reflex in High‐Speed Sequences

et al. 2022

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“…However after detection of organic lesions of the glottis, the most important is the differential diagnosis between benign and malignant lesions (Sigston et al 2006 ; Gandhi et al 2021 ). The golden standard remains clinical assessment with the establishment of the initial diagnosis, followed by a surgical approach—either biopsy or complete removal of the lesion with subsequent determination of the final diagnosis based on postoperative histopathology.…”

Section: Introductionmentioning

confidence: 99%

Value of high-speed videoendoscopy as an auxiliary tool in differentiation of benign and malignant unilateral vocal lesions

Malinowski,

Pietruszewska,

Kowalczyk

et al. 2024

J Cancer Res Clin Oncol

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Purpose The study aimed to assess the relevance of objective vibratory parameters derived from high-speed videolaryngoscopy (HSV) as a supporting tool, to assist clinicians in establishing the initial diagnosis of benign and malignant glottal organic lesions. Methods The HSV examinations were conducted in 175 subjects: 50 normophonic, 85 subjects with benign vocal fold lesions, and 40 with early glottic cancer; organic lesions were confirmed by histopathologic examination. The parameters, derived from HSV kymography: amplitude, symmetry, and glottal dynamic characteristics, were compared statistically between the groups with the following ROC analysis. Results Among 14 calculated parameters, 10 differed significantly between the groups. Four of them, the average resultant amplitude of the involved vocal fold (AmpInvolvedAvg), average amplitude asymmetry for the whole glottis and its middle third part (AmplAsymAvg; AmplAsymAvg_2/3), and absolute average phase difference (AbsPhaseDiffAvg), showed significant differences between benign and malignant lesions. Amplitude values were decreasing, while asymmetry and phase difference values were increasing with the risk of malignancy. In ROC analysis, the highest AUC was observed for AmpAsymAvg (0.719; p < 0.0001), and next in order was AmpInvolvedAvg (0.70; p = 0.0002). Conclusion The golden standard in the diagnosis of organic lesions of glottis remains clinical examination with videolaryngoscopy, confirmed by histopathological examination. Our results showed that measurements of amplitude, asymmetry, and phase of vibrations in malignant vocal fold masses deteriorate significantly in comparison to benign vocal lesions. High-speed videolaryngoscopy could aid their preliminary differentiation noninvasively before histopathological examination; however, further research on larger groups is needed.

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“…A discussion of statistics ended up with a plan for randomisation for calculations. High-speed video is usable to quantify vocal fold measurements [2][3][4][5][6][7][8][9]. Difficulties with light and spatial cameras have been discussed [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Laryngoscopy for Quantitative Vocal Fold Analysis in Combination with AI, A Cohort Study of Manual Artefacts

Sousa¹,

Almeida

Alves

2021

SJO

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Introduction:A cohort of high-speed videoendoscopies was evaluated for usability for deep learning. The aim of our study was to find the percentage of our high-speed videos (15.732) that could be used for deep learning (AI). A screening of the material showed that some videos had artefacts, making them non usable for deep learning. Material:A randomization was made with Wolfram Alpha random number generator selecting between 15.732 videos from 7.909 patients. The various non usable videos are described including the rear parts of the vocal folds not seen, the epiglottis or uvula blocking vision, parts of the vocal folds not seen, no vibration of the vocal folds, persistent constricted larynx, picture taken from an oblique angle, the front part of the vocal folds not seen, and parts of the arytenoid region not seen. Method:Assuming the assessments are independent with regards to whether there is a finding, the total number of assessments with a given finding is binomial distributed. With 100 assessments, an observed incidence of 1, 10 and 25 findings will result in estimated 95% confidence intervals of [0%-3%], [4%-16%] and [17%-33%], respectively. 95% confidence intervals are calculated as Wald test using the asymptotic Normal distribution assumption of the estimated proportion in the binomial distribution. Assuming the incidence of findings for each of the different findings was below 25%, the expected length of the 95% confidence interval is 16%-point (33-17), with 200 and 500 assessments, the corresponding length is 14%-point and 8%-point, respectively. Based on these calculations 100 randomised films were sufficient to be used for calculations. Results and Conclusion:The prospective cohort study of high-speed videos covered 12 years from the February 2007 to January 2019 in an otorhinolaryngology medical centre. 7.909 patients with a total of 15.732 high-speed video films of the larynx including the vocal folds had been consecutively sampled (4.000 frames per second, Richard Wolf Ltd. endocam 5562). Observations on high-speed video for the usable versus non usable videos with 95% confidence intervals, showed that only 51% were usable. The interesting result is that oblique angle pictures (10%) as well as insufficient pictures of the front of the vocal folds and arytenoids (14%) were the largest groups of the non-usable. They can be augmented by the examiner in the future. Various video and deep learning programs are discussed.

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High-speed videolaryngoscopy in early glottic carcinoma patients following transoral CO2 LASER cordectomy

Cited by 6 publications

References 42 publications

Computational Analysis of the Droplet‐Stimulated Laryngeal Adductor Reflex in High‐Speed Sequences

Computational Analysis of the Droplet‐Stimulated Laryngeal Adductor Reflex in High‐Speed Sequences

Value of high-speed videoendoscopy as an auxiliary tool in differentiation of benign and malignant unilateral vocal lesions

Accuracy of Laryngoscopy for Quantitative Vocal Fold Analysis in Combination with AI, A Cohort Study of Manual Artefacts

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