High Strain Rate Testing and Structural Analysis of Pericardial Bioprosthetic Materials

Lee, Jang-Ming; Sa, Haberer; Ca, Pereira; Wa, Naimark; Courtman, DW; Wilson, George D.

doi:10.1520/stp18091s

Cited by 17 publications

(6 citation statements)

References 26 publications

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“…Indeed, strain-rate sensitivity has been demonstrated for heart valve biomaterials under uniaxial 26 and biaxial 38 loading states. In these studies, peak stresses were increased by a factor of 2 when loading times were reduced from 1.0 to 0.1 s. Given the high strain rates observed in the current study ͓Figs.…”

Section: Influence Of Viscoelastic Leaflet Behaviormentioning

confidence: 99%

Surface Strains in the Anterior Leaflet of the Functioning Mitral Valve

Sacks

Baijens

et al. 2002

Annals of Biomedical Engineering

135

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Sacks, Michael S.; He, Z.; Baijens, L.; Wanant, S.; Shah, P.; Sugimoto, H.; Yoganathan, A.P. Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract-The mitral valve ͑MV͒ is a complex anatomical structure whose function involves a delicate force balance and synchronized function of each of its components. Elucidation of the role of each component and their interactions is critical to improving our understanding of MV function, and to form the basis for rational surgical repair. In the present study, we present the first known detailed study of the surface strains in the anterior leaflet in the functioning MV. The threedimensional spatial positions of markers placed in the central region of the MV anterior leaflet in a left ventricle-simulating flow loop over the cardiac cycle were determined. The resulting two-dimensional in-surface strain tensor was computed from the marker positions using a C 0 Lagrangian quadratic finite element. Results demonstrated that during valve closure the anterior leaflet experienced large, anisotropic strains with peak stretch rates of 500%-1000%/s. This rapid stretching was followed by a plateau phase characterized by relatively constant strain state. We hypothesized that the presence of this plateau phase was a result of full straightening of the leaflet collagen fibers upon valve closure. This hypothesis suggests that the MV collagen fibers are designed to allow leaflet coaptation followed by a dramatic increase in stiffness to prevent further leaflet deformation, which would lead to valvula...

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Section: Influence Of Viscoelastic Leaflet Behaviormentioning

confidence: 99%

Surface Strains in the Anterior Leaflet of the Functioning Mitral Valve

Sacks

Baijens

et al. 2002

Annals of Biomedical Engineering

135

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“…Reported studies on mechanical properties of bovine pericardium have utilized base to apex oriented pericardial samples to minimize the effect of tissue anisotropy . However, in this study random orientation was selected purposefully to avoid bias as base to apex orientation of commercially available glutaraldehyde‐treated bovine pericardium, which was used as control, was not known.…”

Section: Discussionmentioning

confidence: 99%

“…Reported studies on mechanical properties of bovine pericardium have utilized base to apex oriented pericardial samples to minimize the effect of tissue anisotropy. 16 However, in this study random orientation was selected purposefully to avoid bias as base to apex orientation of commercially available glutaraldehyde-treated bovine pericardium, which was used as control, was not known. Even then, the result of mechanical testing was unambiguous and showed commercially available glutaraldehyde-treated bovine pericardium to be superior to decellularised bovine pericardium with respect to elasticity and thickness.…”

Section: Discussionmentioning

confidence: 99%

Long-term healing of mildly cross-linked decellularized bovine pericardial aortic patch

Umashankar

Sabareeswaran

Shenoy

2016

J. Biomed. Mater. Res.

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Glutaraldehyde treated bovine pericardium is extensively used in cardiovascular surgery. However, frequent occurrence of failure modes, such as calcification and structural failure, has hard pressed the need for finding an alternate technology. Decellularized bovine pericardium is an emerging technology. Mildly cross-linked decellularized bovine pericardium promotes positive remodeling with insignificant calcification and acute inflammation. In the present study, mildly cross-linked decellularized bovine pericardium was evaluated as a cardiovascular patch by studying mechanical strength as well as graft remodeling, resistance to calcific degeneration and inflammatory response using long duration porcine aortic implantation. It was observed that decellularized bovine pericardium, although thinner and less elastic had equivalent tensile properties such as tensile strength and stiffness when compared to commercially available glutaraldehyde-treated bovine pericardium. It showed the potential for site appropriate remodeling evidenced by host cell incorporation, thinner neointima, graft degradation, and neocollagenisation making it suitable for vascular patch application, whereas glutaraldehyde-treated pericardium failed to integrate with host tissue through timely degradation and host cell incorporation or neocollagenization. Conversely, it elicited persistent acute inflammation and produced calcification. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2145-2152, 2017.

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“…In particular, the assumption that material relaxation ends when the experiment is stopped is unwarranted [5,29], for it is understood that the loading rate affects the stress relaxation [22,38] and that stress relaxation can continue well beyond the time allowed in typical experiments [14]. A clever method to obviate these difficulties has been recently developed by [4] and used in their application of QLV theory to the internal shearing of porcine aortic valve leaflets.…”

Section: Constitutive Equation and Parameter Estimationmentioning

confidence: 99%

A Quasi-linear Viscoelastic Constitutive Equation for the Brain: Application to Hydrocephalus

et al. 2006

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Hydrocephalus is a condition which occurs when an excessive accumulation of cerebrospinal fluid in the brain causes enlargement of the ventricular cavities. Modern treatments of shunt implantation are effective, but have an unacceptably high rate of failure in most reported series. One of the common factors causing shunt failure is the misplacement of the proximal catheter's tip, which can be remedied if the healed configuration of the ventricular space can be predicted. In a recent study we have shown that this is accomplished by a mathematical model which requires as input the knowledge of the speed at which the ventricular walls move inwardly. In this paper we report on a theoretical method of calculating this speed and show that it will become of great practical usefulness as soon as more experimental results become available. Mathematics Subject Classifications (2000) 74L15/92C10 · 74D10

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High Strain Rate Testing and Structural Analysis of Pericardial Bioprosthetic Materials

Cited by 17 publications

References 26 publications

Surface Strains in the Anterior Leaflet of the Functioning Mitral Valve

Surface Strains in the Anterior Leaflet of the Functioning Mitral Valve

Long-term healing of mildly cross-linked decellularized bovine pericardial aortic patch

A Quasi-linear Viscoelastic Constitutive Equation for the Brain: Application to Hydrocephalus

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