High strength porous PLA gyroid scaffolds manufactured via fused deposition modeling for tissue-engineering applications

Alizadeh-Osgouei, M.; Li, Yuncang; Vahid, Alireza; Ataee, Arash; Wen, Cuie

doi:10.1016/j.smaim.2020.10.003

Cited by 97 publications

(56 citation statements)

References 77 publications

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“…Regardless of material composition, all scaffolds underwent elastic deformation, yielding, and rupture during the compressive tests. The activities under compression were different from others’ works, where the gyroid scaffolds underwent elastic deformation (linear stress increment), buckling/densification (insignificant stress increment), and finally deformation after densification along with increased compressive strain (substantial and non-linear stress increment) [ 10 , 39 ]. Meanwhile, the cracks propagated along the boundary of FDM-deposited layers were observed.…”

Section: Discussioncontrasting

confidence: 57%

Additive-Manufactured Gyroid Scaffolds of Magnesium Oxide, Phosphate Glass Fiber and Polylactic Acid Composite for Bone Tissue Engineering

Liu

Rudd

2021

Polymers

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Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability to release Ca, P, and Mg during degradation, thus promoting the bone repair. Nevertheless, glass degradation tends to acidify the surrounding aqueous environment, which may adversely affect the viability and bone-forming activities of osteoblasts. In this work, MgO was investigated as a neutralizing agent. Porous network-phase gyroid scaffolds were additive-manufactured using four different materials: PLA, MgO/PLA, PGF/PLA, and (MgO + PGF)/PLA. The addition of PGF enhanced compressive properties of scaffolds, and the resultant scaffolds were comparably strong and stiff with human trabecular bone. While the degradation of PGF/PLA composite induced considerable acidity in degradation media and intensified the degradation of PGF in return, the degradation media of (MgO + PGF)/PLA maintained a neutral pH close to a physiological environment. The experiment results indicated the possible mechanism of MgO as the neutralizing agent: the local acidity was buffered as the MgO reacted with the acidic degradation products thereby inhibiting the degradation of PGF from being intensified in an acidic environment. The (MgO + PGF)/PLA composite scaffold appears to be a candidate for bone tissue engineering.

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Section: Discussioncontrasting

confidence: 57%

Additive-Manufactured Gyroid Scaffolds of Magnesium Oxide, Phosphate Glass Fiber and Polylactic Acid Composite for Bone Tissue Engineering

Liu

Rudd

2021

Polymers

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“…Essential for developing nanofibrous scaffolds, homogenous mixtures made of fibres with high tensile strength [24] Process depends on many variables, problematic to obtain 3D structures with the required pore size needed for biomedical application [26,27] Freeze drying Used in a variety of purposes, capability of obtaining high temperature, manageable pore size by changing freezing method [24] High energy consumption, long term timescale, generation of irregular size pores [28] Gas foaming Porosity up to 56.71% [29] Temperature dependent, product obtained from decreased temperature might have closed pore structure or a solid polymeric skin [30] Thermal induced phase separation Porosity up to 80% [31], can use low temperature to integrate bioactive molecules [24] Only used for polymers amenable to phase separation [31] Rapid prototyping (RP) Bioprinting Low cost, higher accuracy, and greater shape complexity [24] Depends on the cells/biomaterials used [32] Fused deposition modelling (FDM) High tensile strength [24] Has limited application to biodegradable polymers [33] Solvent based extrusion free forming (SEF)…”

Section: Conventional Fabrication Techniques Electrospinningmentioning

confidence: 99%

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

2021

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Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

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“…Three-dimensional (3D) printing can readily fabricate complex 3D structures, which is hard to achieve by traditional processing methods [1,2]. Therefore, 3D printing has wide applications in various fields, such as electronics, biomedical engineering, energy industry, and aerospace [3][4][5][6][7][8][9][10][11][12][13][14]. There are many types of 3D printing technologies such as digital light processing (DLP), selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM), and direct ink writing (DIW) [15,16].…”

Section: Introductionmentioning

confidence: 99%

Self-healing materials enable free-standing seamless large-scale 3D printing

et al. 2021

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Three-dimensional (3D) printing has had a large impact on various fields, with fused deposition modeling (FDM) being the most versatile and cost-effective 3D printing technology. However, FDM often requires sacrificial support structures, which significantly complicates the processing and increase the cost. Furthermore, poor layer-to-layer adhesion greatly affects the mechanical stability of 3D-printed objects. Here, we present a new Print-Healing strategy to address the aforementioned challenges. A polymer ink (Cu-DOU-CPU) with synergetic triple dynamic bonds was developed to have excellent printability and room-temperature self-healing ability. Objects with various shapes were printed using a simple compact 3D printer, and readily assembled into large sophisticated architectures via self-healing. Triple dynamic bonds induce strong binding between layers. Additionally, damaged printed objects can spontaneously heal, which significantly elongates their service life. This work paves a simple and powerful way to solve the key bottlenecks in FDM 3D printing, and will have diverse applications.

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High strength porous PLA gyroid scaffolds manufactured via fused deposition modeling for tissue-engineering applications

Cited by 97 publications

References 77 publications

Additive-Manufactured Gyroid Scaffolds of Magnesium Oxide, Phosphate Glass Fiber and Polylactic Acid Composite for Bone Tissue Engineering

Additive-Manufactured Gyroid Scaffolds of Magnesium Oxide, Phosphate Glass Fiber and Polylactic Acid Composite for Bone Tissue Engineering

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Self-healing materials enable free-standing seamless large-scale 3D printing

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