High sucrose intake exacerbates airway inflammation through pathogenic Th2 and Th17 response in ovalbumin (OVA)-induced acute allergic asthma in C57BL/6 mice

Kim, Hyo Jin; Dinh, Duong Thi Thuy; Yang, Jiwon; Herath, Kalahe Hewage Iresha Nadeeka Madushani; Seo, Seok Hee; Son, Young-Ok; Kang, Inhae; Jee, Youngheun

doi:10.1016/j.jnutbio.2023.109504

The Journal of Nutritional Biochemistry

2024

DOI: 10.1016/j.jnutbio.2023.109504

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High sucrose intake exacerbates airway inflammation through pathogenic Th2 and Th17 response in ovalbumin (OVA)-induced acute allergic asthma in C57BL/6 mice

Hyo Jin Kim,

Duong Thi Thuy Dinh,

Jiwon Yang

et al.

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2024

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Cited by 4 publications

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Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway

Kun,

Xiaomei,

Lei

et al. 2024

International Immunopharmacology

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Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway

Kun,

Xiaomei,

Lei

et al. 2024

International Immunopharmacology

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Excess dietary sugar and its impact on periodontal inflammation: a narrative review

Shanmugasundaram,

Karmakar

2024

BDJ Open

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Introduction Sugar is omnipresent in the current food environment and sugar consumption has drastically risen over the past century. Extensive evidence highlights the negative health consequences of consuming excess dietary sugars, leading the World Health Organization (WHO) and the American Heart Association (AHA) to devise guidelines to restrict sugar intake. According to the WHO’s Global Oral Health Status Report of 2022, oral diseases and severe periodontitis are a massive public health problem, and dietary sugars are a modifiable risk factor. Methods We conducted a literature review using key databases to summarise the health effects of excessive sugar consumption and their potential role in periodontal inflammation. Results and conclusion Available evidence suggests that excess dietary fructose and sucrose can cause low-grade systemic inflammation; and induce dysbiosis in both gut and the oral microbiota. Also, dietary sugar is potentially addictive and hypercaloric and its overconsumption can lead to obesity, metabolic syndrome, and other risk factors for periodontal inflammation. Hence, an unbalanced diet with excess dietary sugars holds the potential to initiate and aggravate periodontal inflammation. In the modern food environment that enables and facilitates a high-sugar diet, adopting a diverse diet and restricting sugar intake according to WHO and AHA guidelines seem beneficial to systemic and periodontal health. Since clinical evidence is limited, future research should study the effectiveness of dietary interventions that control sugar consumption in preventing and managing the global public health problem of periodontal inflammation.

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Positive association between dietary total sugar intake and eosinophil counts in asthmatic children and adolescents in the United States: a cross-sectional study

Du,

Sun,

Zhang

et al. 2024

Journal of Asthma

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High sucrose intake exacerbates airway inflammation through pathogenic Th2 and Th17 response in ovalbumin (OVA)-induced acute allergic asthma in C57BL/6 mice

Cited by 4 publications

References 59 publications

Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway

Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway

Excess dietary sugar and its impact on periodontal inflammation: a narrative review

Positive association between dietary total sugar intake and eosinophil counts in asthmatic children and adolescents in the United States: a cross-sectional study

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