High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring's liver

Ergaz, Zivanit; Weinstein-Fudim, Liza; Ornoy, Asher

doi:10.1002/bdr2.1341

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Furthermore, the current literature suggests positive correlations between Cu and markers of oxidative balance, including total antioxidant status (TOS) and oxidative stress index (OSI) [ 106 ]. Although the relationship between the mentioned enzymes involved in maintaining the oxidative balance and Cu, in general, seems unquestionable, the relationship of these enzymes with dietary copper requires further investigation [ 107 ].…”

Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since the treatment options for this disease are still limited, and the cure rate is unsatisfactory, the search for ways to treat symptoms and modify the course of the disease is of key importance in improving the quality of life of patients with endometriosis. So far, the literature has shown that nutrition can influence endometriosis through hormonal modification and altering the inflammatory or oxidative response. Since the importance of nutrition in this disease is still a subject of scientific research, we aimed to summarize the current knowledge on the role of dietary modifications in endometriosis. Our review showed that nutrients with anti-inflammatory and antioxidant properties, including most vitamins and several trace elements, may influence the pathogenesis of endometriosis and can be considered as the nutrients preventing the development of endometriosis. However, despite the many discoveries described in this review, further interdisciplinary research on this topic seems to be extremely important, as in the future, it may result in the development of personalized therapies supporting the treatment of endometriosis.

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Section: The Role Of Selected Dietary Components In the Course Of End...mentioning

confidence: 99%

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

Abramiuk,

Mertowska,

Frankowska

et al. 2024

Nutrients

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“…²ìóíîã³ñòîõ³ì³÷í³ ìåòîäè îö³íþâàííÿ åêñïðåñ³¿ BAX âèêîðèñòîâóþòüñÿ ïðè äîñë³äaeåíí³ ñòàíó îðãàí³â òðàâíî¿ ñèñòåìè çà óìîâ ïîðóøåííÿ îáì³íó ðå÷îâèí. Çà äîïîìîãîþ öèõ ìåòîä³â âäàëîñÿ ïîêàçàòè íàÿâí³ñòü çì³í åêñïðåñ³¿ á³ëêó BAX ó ïå÷³íö³ åêñïåðèìåíòàëüíèõ ùóð³â, õâîðèõ íà ä³àáåò äðóãîãî òèïó [8].…”

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INFORMATIVE BIOMARKERS IN THE STUDY OF THE PROCESSES OF PROLIFERATION, APOPTOSIS AND AUTOPHAGY IN THE TISSUES OF THE DIGESTIVE SYSTEM IN EXPERIMENTAL METABOLIC SYNDROME. Review

Smirnov

2019

Med. Sci. of Ukr.

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Diabetes mellitus is a widespread disease in the world. Diabetes mellitus type 2 is more and more common in younger people and has many complications. In particular, diabetes causes complications in the gastrointestinal tract. A metabolic syndrome is a state in which metabolic disorders occur. A certain role in the development of metabolic syndrome belongs to the gastrointestinal tract. On the other hand, the presence of metabolic syndrome is a significant risk factor for diseases of the gastrointestinal tract. The development of complications of diabetes and metabolic syndrome is known to be associated with disorders of cell proliferation, apoptosis, and autophagy. Immunohistochemical methods are widely used in scientific research to evaluate the state of cell proliferation, apoptosis and autophagy in the tissues of the digestive system, in particular in the liver, stomach, pancreas, small intestine and colon. Immunohistological methods provide valuable data on the nature of changes in the processes of cell proliferation, apoptosis and autophagy in the tissues of the digestive system under conditions of metabolic disorders, in particular in diabetes and in metabolic syndrome. Therefore, the use of immunohistochemical methods to determine the proliferative activity by the expression of nuclear antigen Ki-67 and by the expression of nuclear antigen of proliferating cells PCNA , assessment of the state of apoptosis processes by expression of protein Bcl-2 and protein BAX, as well as to determine the nature of the processes of autopsy by expression of Beclin-1 (BECN1) in the tissues of the digestive system in experimental metabolic syndrome and diabetes mellitus type 2 is quite reasonable.

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Efectos sistémicos del consumo de sacarosa y su asociación con la respuesta inmunitaria: revisión sistemática

Martínez Carrillo,

Cruz Estrada,

Guadarrama López

et al. 2024

LATAM

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La sacarosa se consume en casi todos los alimentos, su principal fuente es el azúcar de caña. El objetivo fue identificar los efectos sistémicos del consumo de sacarosa y su asociación con la respuesta inmunitaria. Se utilizó la red EQUATOR y FAIRsharing, con la directriz de Elementos Preferidos de Informes para Revisiones Sistemáticas y Metanálisis (PRISMA), a través de búsquedas manuales y sistemáticas en cuatro bases de datos: PubMed, Multidisciplinary Digital Publishing Institute (MDPI), Frontiers, Cochrane del primero de enero de 2005 al 30 de abril de 2023. El consumo de sacarosa ocasiona efectos diversos en el organismo, en el sistema cardiovascular, estimula la inflamación subclínica, aumenta la PCR, IL-6, TNF-α, IL-β, así como los niveles de leptina. Se asocia con la presencia de sobrepeso/obesidad, Diabetes Mellitus Tipo 2 y en enfermedades musculoesqueléticas. Un elevado consumo de azúcar refinada, productos ultraprocesados o azúcares añadidos, condicionan un riesgo de padecer enfermedades crónico-degenerativas incluso más que las grasas saturadas. También conduce a enfermedad coronaria, hígado graso con resistencia a la insulina, niveles elevados de glucosa, hiperlipidemia, síndrome metabólico y producción de Especies Reactivas del Oxígeno. El consumo de azúcar es seguro, no hay limitación de consumo en alimentos o prácticas de fabricación, por tanto, es importante continuar investigando los efectos a corto, mediano y largo plazo del azúcar en la dieta, su concentración ideal de consumo y su influencia en la activación y regulación de la respuesta inmunitaria.

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High sucrose low copper diet in pregnant diabetic rats induces transient oxidative stress, hypoxia, and apoptosis in the offspring's liver

Cited by 3 publications

References 41 publications

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

How Can Selected Dietary Ingredients Influence the Development and Progression of Endometriosis?

INFORMATIVE BIOMARKERS IN THE STUDY OF THE PROCESSES OF PROLIFERATION, APOPTOSIS AND AUTOPHAGY IN THE TISSUES OF THE DIGESTIVE SYSTEM IN EXPERIMENTAL METABOLIC SYNDROME. Review

Efectos sistémicos del consumo de sacarosa y su asociación con la respuesta inmunitaria: revisión sistemática

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