High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine

Thaeomor, Atcharaporn; Wyss, J. Michael; Jirakulsomchok, Dusit; Roysommuti, Sanya

doi:10.1186/1423-0127-17-s1-s30

Cited by 21 publications

(26 citation statements)

References 39 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frequency domains of arterial pressure pulse spectrum were analyzed using the Acknowledge software to indirectly estimate the sympathetic (low frequency 0.3–0.5 Hz, LF) and the parasympathetic nerve activities (high frequency 0.5–4.0 Hz, HF). The percent power spectral densities of LF or HF to the total power of LF plus HF indicate sympathetic and parasympathetic nerve activity, respectively (Roysommuti S 2009; Thaeomor A 2010). Baroreflex sensitivity values were calculated from changes in heart rates (BSHR) or renal nerve activity (BSRA) per changes in mean arterial pressures.…”

Section: 2 Methodsmentioning

confidence: 99%

“…2010b), while perinatal taurine depletion paired with a high sugar diet after weaning blunts baroreflex function and depresses the autonomic nervous system control of arterial pressure (Roysommuti el al. 2009b; Thaeomor el al. 2010).…”

Section: 1 Introductionmentioning

confidence: 99%

“…In contrast, a high sugar diet markedly depresses baroreflex function and increases sympathetic nerve activity in both sexes (Roysommuti el al. 2009b; Thaeomor el al. 2010).…”

Section: 1 Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

Thaeomor

Wyss

Schaffer

et al. 2013

Advances in Experimental Medicine and Biology

Self Cite

View full text Add to dashboard Cite

In adult rats, perinatal taurine depletion followed by high sugar intake alters neural and renal control of arterial pressure via the renin-angiotensin system. This study tests the hypothesis that perinatal taurine supplementation predisposes adult female rats to the adverse arterial pressure effect of high sugar intake via the renin-angiotensin system, rather than via estrogen. Female Sprague-Dawley (SD) rats were fed normal rat chow with 3% taurine (TS) or water alone (C) from conception to weaning. Their female offspring were fed normal rat chow with either 5% glucose in tap water (TSG, CG) or tap water alone (TSW, CW). At 7-8 weeks of age, the female offspring's renin-angiotensin system or estrogen receptors were inhibited by captopril or tamoxifen, respectively. Body weight, heart weight, kidney weight, mean arterial pressures (MAP) and heart rates were not significantly different among control groups (without captopril or tamoxifen). Captopril (but not tamoxifen) decreased MAP but not heart rates in all groups. In TSG compared to TSW, CW and CG groups, baroreflex sensitivity of heart rate (BS-HR) and renal nerve activity (BS-RN) were significantly decreased. Neither captopril nor tamoxifen altered BS-HR in TSG, but tamoxifen (but not captopril) restored TSG BS-RN to CW or CG control levels. Perinatal taurine imbalance (either increase or decrease) did not disturb sympathetic and parasympathetic nerve activity in the adult rats on high or basal sugar intake. Compared to its effect in CW and CG groups, tamoxifen increased sympathetic but decreased parasympathetic activity less in TSG and TSW groups. Inhibition of the renin-angiotensin system did not affect autonomic nerve activity in any group. These data suggest that in adult female rats that are perinatally supplemented of taurine, high sugar intake after weaning blunts arterial baroreflex via an estrogen (but not renin-angiotensin) mechanism.

show abstract

Section: 2 Methodsmentioning

confidence: 99%

Section: 1 Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

Thaeomor

Wyss

Schaffer

et al. 2013

Advances in Experimental Medicine and Biology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Taurine supplementation was also reported to decrease systolic and diastolic blood pressure in young patients with borderline hypertension [18] , but not in healthy men [19] . In addition, perinatal taurine exposure affects adult susceptibility to sugar-induced hypertension in rats [20][21][22][23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

Taurine supplementation in spontaneously hypertensive rats: Advantages and limitations for human applications

Suwanich

Wyss²,

Roysommuti³

2013

WJC

View full text Add to dashboard Cite

Taurine (2-aminoethanesulfonic acid) is a β-amino acid found in many tissues particularly brain, myocardium, and kidney. It plays several physiological roles including cardiac contraction, antioxidation, and blunting of hypertension. Though several lines of evidence indicate that dietary taurine can reduce hypertension in humans and in animal models, evidence that taurine supplementation reduces hypertension in humans has not been conclusive. One reason for the inconclusive nature of past studies may be that taurine having both positive and negative effects on cardiovascular system depending on when it is assessed, some effects may occur early, while others only appear later. Further, other consideration may play a role, e.g. , taurine supplementation improves hypertension in spontaneously hypertensive rats on a low salt diet but fails to attenuate hypertension on a high salt diet. In humans, some epidemiologic studies indicate that people with high taurine and low salt diets display lower arterial pressure than those with low taurine and high salt diets. Differences in techniques for measuring arterial pressure, duration of treatment, and animal models likely affect the response in different studies. This review considers both the positive and negative effects of taurine on blood pressure in animal models and their applications for human interventions.© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Arterial pressure; Circadian rhythm; Hypertension; Spontaneously hypertensive rat; NaCl; Taurine Core tip: Many reports indicate that dietary taurine can reduce hypertension in humans and in animal models; however, the hypotensive effect of taurine supplementation depends on many factors. Taurine supplementation improves hypertension in spontaneously hypertensive rats on a low salt diet but fails to attenuate hypertension on a high salt diet. In humans, some epidemiologic studies suggest that people with high taurine and low salt diets display lower arterial pressure than those with low taurine and high salt diets. This review considers both positive and negative effects of taurine on blood pressure in animal models of hypertension to apply for human interventions.Suwanich A, Wyss JM, Roysommuti S. Taurine supplementation in spontaneously hypertensive rats: Advantages and limitations for human applications.

show abstract

“…In such animals, the sympathetic nervous system can be markedly overactive in response to a high sugar diet (Roysommuti el al. 2009a; Thaeomor el al. 2010).…”

Section: 1 Introductionmentioning

confidence: 99%

Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats

Khimsuksri

Wyss

Thaeomor

et al. 2013

Advances in Experimental Medicine and Biology

Self Cite

View full text Add to dashboard Cite

Perinatal taurine excess or deficit influences adult health and disease, especially relative to the autonomic nervous system. This study tests the hypothesis that perinatal taurine exposure influences adult autonomic nervous system control of arterial pressure in response to acute electrical tooth pulp stimulation. Female Sprague-Dawley rats were fed normal rat chow with 3% β-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Their male offspring were fed normal rat chow and tap water throughout the experiment. At 8–10 weeks of age, blood chemistry, arterial pressure, heart rate and renal sympathetic nerve activity were measured in anesthetized rats. Age, body weight, mean arterial pressure, heart rate, plasma electrolytes, blood urea nitrogen, plasma creatinine and plasma cortisol were not significantly different among the three groups. Before tooth pulp stimulation, low (0.3–0.5 Hz) and high frequency (0.5–4.0 Hz) power spectral densities of arterial pressure were not significantly different among groups, while the power spectral densities of renal sympathetic nerve activity were significantly decreased in TD compared to control rats. Tooth pulp stimulation did not change arterial pressure, heart rate, renal sympathetic nerve and arterial pressure power spectral densities in the 0.3–4.0 Hz spectrum or renal sympathetic nerve firing rate in any group. In contrast, perinatal taurine imbalance disturbed very low frequency power spectral densities of both arterial pressure and renal sympathetic nerve activity (below 0.1 Hz), both before and after the tooth pulp stimulation. The power densities of TS were most sensitive to ganglionic blockade and central adrenergic inhibition, while those of TD were sensitive to both central and peripheral adrenergic inhibition. The present data indicate that perinatal taurine imbalance can lead to aberrant autonomic nervous system responses in adult male rats.

show abstract

High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine

Cited by 21 publications

References 39 publications

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

Taurine supplementation in spontaneously hypertensive rats: Advantages and limitations for human applications

Perinatal Taurine Exposure Programs Patterns of Autonomic Nerve Activity Responses to Tooth Pulp Stimulation in Adult Male Rats

Contact Info

Product

Resources

About