High Survivin and Low Zinc Finger of the Cerebellum 1 Expression Indicates Poor Prognosis in Triple-negative Breast Carcinoma

Shi, Chun-tao; Ma, Jun; Shi, Qifeng; Zhang, Ye; Wang, Haonan

doi:10.4048/jbc.2019.22.e20

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Therefore, the expression of survivin appeared to be of higher importance for the malignant progression of TNBC instead of non-TNBC, where patients with TNBC showing higher expression levels of survivin tended to exhibit more severe malignancy, resulting in poorer prognoses. Shi et al also drew a similar conclusion in a previous study with TNBC, whereby survivin-positive patients tended to have shorter OS and disease-free survival times (36), but Dogu et al and Jha et al did not observe any effects exerted by survivin on the prognosis of patients with TNBC (45,46). These discrepancies may be attributed to the different antibodies used, distinct sample groups or the cut-off criteria set prior to evaluation.…”

Section: Discussionmentioning

confidence: 69%

“…In terms of TNBC, Yamanaka et al found that inhibition of survivin expression can significantly suppress the metastasis of TNBC MDA-MB-231 cells, while also significantly prolonging the survival time of tumor-bearing mice (35). Furthermore, Shi et al (36) found that survivin expression was associated with the histological grade and TNM stage of patients with TNBC, where the survival rate of patients with survivin-positive TNBC was lower. Observations from these aforementioned studies suggest that survivin may be involved in the pathophysiological process of TNBC and therefore attention should be paid to the potential value of applying survivin as a prognostic indicator.…”

Section: Significance Of Combined Tgf-β1 and Survivin Expression On T...mentioning

confidence: 99%

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Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Liu

Jiang

et al. 2022

Oncol Lett

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Compared with other types of breast cancer, triple-negative breast cancer (TNBC) has the characteristics of rapid progression, a lack of specific molecular targets for treatment and a poor prognosis. However, based on previously published studies, TGF-β1 and survivin are potentially meaningful for the prognosis of patients with TNBC. The present study was therefore designed to measure and compare the expression of transforming growth factor-β1 (TGF-β1) and survivin in tissue samples of TNBC and non-TNBC patients in order to evaluate their ability as prognostic indicators. In total, 90 TNBC and 52 non-TNBC tissue specimens were selected, following which immunohistochemistry was used to detect the expression of TGF-β1 and survivin in the cancer tissues. Subsequently, the potential association between the expression levels of these two proteins and the clinicopathological variables was analyzed. The expression levels of TGF-β1 and survivin in TNBC tissues were found to be significantly higher compared with those in the non-TNBC tissues. In addition, the results of the present study demonstrated that TGF-β1 expression was positively associated with survivin expression in the TNBC samples, but no significant correlation was found between TGF-β1 and survivin expression in the non-TNBC samples. Kaplan-Meier (K-M) analysis was performed to assess the levels of TGF-β1 and survivin in regard to patient survival, and univariate and multivariate Cox analyses of TGF-β1 and survivin protein expression were performed to analyze the overall survival (OS) and progression-free survival (PFS) rates of patients with TNBC and non-TNBC. Although multivariate Cox analysis demonstrated that neither TGF-β1 or survivin were independent prognostic predictors of TNBC or non-TNBC, results of the K-M curve revealed that patients with TNBC with TGF-β1-and survivin-positive breast cancer exhibited shorter OS and PFS times. Multivariate Cox analysis demonstrated that in patients with TNBC, the combined expression of TGF-β1 and survivin may yield additional prognostic information, compared with patients with non-TNBC.

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Section: Discussionmentioning

confidence: 69%

Section: Significance Of Combined Tgf-β1 and Survivin Expression On T...mentioning

confidence: 99%

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Liu

Jiang

et al. 2022

Oncol Lett

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“…According to the authors, survivin and epidermal growth factor receptor expression evaluated by immunohistochemistry were considered of prognostic value for TNBC. Likewise, survivin expression together with zinc finger of the cerebellum 1 also showed prognostic potential 13 ; in this case, the expression of these was evaluated in frozen tumor samples using quantitative polymerase chain reaction (qPCR) and in paraffin-embedded samples by immunohistochemistry. Our results show that the isolated expression of survivin obtained by qPCR can be considered a prognostic marker for all breast tumor subtypes, and that this evaluation can be performed on stored paraffin-embedded samples.…”

Section: Discussionmentioning

confidence: 99%

Survivin expression as a prognostic marker for breast cancer

Quidute,

Perez

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Due to the speed of development observed in breast cancer, several studies aimed at discovering new biomarkers have been carried out in order to arrive at an early diagnosis. As survivin plays a fundamental role in the evasion of apoptosis in tumor cells, the aim of this study was to verify the expression profile of the survivin gene in paraffin-embedded breast tumor samples and associate it with the clinical characteristics of the patients. METHODS: This is a cross-sectional study, for which 100 tumor samples were obtained from cancer patients treated throughout the year 2019 at Instituto de Mama do Cariri (Juazeiro do Norte, in the state of Ceará). This study included women over 30 years old who had confirmed breast cancer through anatomopathological examination but excluded those with non-neoplastic breast comorbidities, other neoplasms, or chronic diseases. Survivin gene expression was assessed by quantitative polymerase chain reaction. RESULTS: The expression of survivin is associated with the lack of expression of estrogen (p=0.027) and progesterone (p>0.0005) receptors. It means that survivin expression is higher in patients in which labeling was absent for estrogen receptor and progesterone receptor. CONCLUSION: Our data reinforce that survivin expression is higher in estrogen receptor-patients, thus representing an additional prognostic tool.

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“…Specific inhibition of survivin could induce apoptosis and suppress the proliferation of hepatocellular carcinoma (HCC), and similar effects were observed in CRC, leukemia, and breast cancer, among others. Therefore, survivin might be a promising target for tumor inhibition ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells

Shi¹,

Wang²,

Zhu³

et al. 2022

J Gastrointest Oncol

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Background: Colorectal carcinoma (CRC) treatment remains severe. Survivin is aberrantly overexpressed in CRC tissues and might be a potential target for CRC treatment. TDB-6 is a new taspine derivative. The purpose of this study is to investigate the inhibitory effect of TDB-6 on CRC and its underlying mechanism. Methods:The MTT assay and xenograft model were utilized to investigate the inhibitory effect of TDB-6 on LoVo cells in vitro and in vivo. Hoechst staining and Annexin-V FITC/PI analysis were conducted to study the effect of TDB-6 on LoVo cell apoptosis. Mitochondrial membrane potential (Δψm) assay was conducted to demonstrated whether TDB-6 could induce mitochondrial-mediated apoptosis of LoVo cells.Western blotting was conducted to investigate the effect of TDB-6 on survivin protein and caspase/Bcl-2/ Cyto-C signaling. Results:The results indicated that TDB-6 induced mitochondria-mediated apoptosis and inhibited the proliferation and growth of LoVo cells in vitro and in vivo. Mechanistic investigation utilizing western blotting indicated that TDB-6 inhibited survivin protein expression, and the inhibitory effect was augmented by TDB-6 and YM-155 co-administration, which revealed that TDB-6 might induce apoptosis of LoVo cells by targeted regulation of survivin. TDB-6 also regulated survivin downstream signaling. It significantly increased the protein level of cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, cleaved-PARP, and Cyto-C, and decreased the protein level of Bcl-2.Conclusions: TDB-6 might be a promising survivin inhibitor with great potential for CRC treatment.

show abstract

High Survivin and Low Zinc Finger of the Cerebellum 1 Expression Indicates Poor Prognosis in Triple-negative Breast Carcinoma

Cited by 7 publications

References 28 publications

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Survivin expression as a prognostic marker for breast cancer

Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells

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