High Temperature- and High Pressure-Processed Garlic Improves Lipid Profiles in Rats Fed High Cholesterol Diets

Sohn, Chan Wok; Kim, Hyunae; You, Bo; Kim, Min Jee; Kim, Hyo Jin; Lee, Ji Yeon; Sok, Dai‐Eun; Kim, Jin Hee; Lee, Kun Jong; Kim, Mee Ree

doi:10.1089/jmf.2011.1922

Cited by 25 publications

(16 citation statements)

References 19 publications

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“…In this study, the treatment with Ator drug showed significant increase in WBC in the test groups compared to the control. A significant depletion in serum HDL level was recorded in obese rats as compared to lean control rats, this result was in agreement with Sohn et al [62] who reported that hypercholesterolemia and hypertriglyceridemia have been previously detected in obese rats. The reduction in serum triglycerides leads to decreased adipose tissue mass [63,18].…”

Section: Discussionsupporting

confidence: 92%

Interaction Between Ator and Fennel Remedies in the Treatment of Obesity in Rats

ghazaly¹,

Radwan²,

Zaatout³

et al. 2019

JOM

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Obesity can be defined as a condition of abnormal or excess fat accumulation in adipose tissue, to the extent that health may be impaired. Fennel is one of the oldest spice plants which widely grows in arid and semi -arid and due to its economic importance and pharmaceutical industry usage. This plant has anti-inflammatory and analgesic effect and is effective in gastrointestinal disorder treatment. The aim of the present study was to evaluate the phytochemical characteristics and therapeutic properties of this medicinal plant. The current study demonstrates that the alteration induced by high fat diet causing changes in blood parameters. These changes are exhibited through a decrease in RBCs, Ht, Hb and platelet and these changes could be due to oxidative stress, which lead to lipid peroxidation in RBCs membranes, auto oxidation of hemoglobin. As regards the total WBCs, lymphocytes and monocytes showed marked decrease. While a distinct increase in the percentage of neutrophils and eosinophil. The present, demonstrates that rats treated with (fennel), (ator) and (fennel with ator) exposure provided significant protection to the altered hematological variables. The effect of the treatment with fennel and ator more effect than fennel only and ator only. The finding of this study indicates that the concentration of Malondialdehyde (MDA) and Myeloperoxidase (MPO) in liver homogenates of the fennel and ator group significant decrease than group (3) and group (4) and the obese group. There is a growing awareness that obesity is a prime risk factor for the development of dyslipidemia profile and that oxidative stress may play a role in various adverse effects of obesity.

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Section: Discussionsupporting

confidence: 92%

Interaction Between Ator and Fennel Remedies in the Treatment of Obesity in Rats

ghazaly¹,

Radwan²,

Zaatout³

et al. 2019

JOM

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“…We verified similar trends in the CGP group, fed with 13.52 mg of allicin/kg of animal mass, to the study conducted by Elkayam et al [24]. Other studies conducted by Lee et al [25] and Sohn et al [9], both with diets enriched with garlic powder, did not show any change in food intake and in weight gain.…”

Section: Cultivarssupporting

confidence: 91%

“…Atherosclerosis is one of the highest risk factor in hypertension development and CVD [9]. CVD are the main causes of death among the Western population.…”

Section: Introductionmentioning

confidence: 99%

Lipid Profiles are Altered in Rats Fed with Different Garlic Cultivars

Silva¹,

Moretti²,

Mattos³

2015

Int J Biomed

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Garlic has antioxidant and hypocholesterolemic properties that are attributed to its organosulfur compounds being allicin, which is reported to be the most active of these compounds. We hypothesized that allicin content could reduce plasma concentrations of triglycerides (TG), total cholesterol (TC), HDL (high density lipoproteins), VLDL (very low density lipoproteins), and glucose. Two different cultivars of commercial garlic, Peruano and Jinxiang, were used. Thirty male Wistar rats were distributed into 6 groups and fed for 15 days with standard diet (Control), Control with Peruano garlic treatment (CGP), Control with Jinxiang garlic treatment (CGCH), cholesterol-added control diet (CholC), cholesterol-added diet with Peruano garlic treatment (CholGP), and cholesterol-added diet with Jinxiang garlic treatment (CholGCH). Garlic treatment consisted of a daily oral dose of 1ml of lyophilized garlic. We observed that garlic treatment in Control group significantly reduced plasma TG and VLDL concentrations. The CGCH group presented a significant increase in plasma TC levels (25.5%) and glucose (11%). No significant changes in TC, HDL, TG and VLDL were observed in CholGP and CholGCH, but levels of fasting plasma glucose were increased: CholGP (23%) and CholGCH (27.5%). Results suggested allicin treatments alter lipid profile in rats. Nevertheless, further studies are necessary to address the increase in plasma glucose levels.

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“…The authors of these previous studies believe that hypercholesterolemia should be considered as a risk factor for hepatic fibrosis, in addition to atherosclerosis and coronary artery disease 38 . Also shown in the study by Sohn CW was that the plasma TG level significantly increased after the feeding of high-cholesterol diets to rats 39 . Interestingly, our findings indicate no significant changes in the plasma TG but conspicuous steatosis and elevated triglycerides in the liver.…”

Section: Discussionmentioning

confidence: 87%

Chronic Moderate Alcohol Intakes Accelerate SR-B1 Mediated Reverse Cholesterol Transport

Diao

Liu

et al. 2016

Sci Rep

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Cholesterol is essential for all animal life. However, a high level of cholesterol in the body is strongly associated with the progression of various severe diseases. In our study, the potential involvement of alcohol in the regulation of high density lipoprotein (HDL) receptor scavenger receptor class B and type I (SR-B1)-mediated reverse cholesterol transport was investigated. We separated male C57BL/6 mice into four diets: control, alcohol, Control + HC and alcohol + HC. The SR-B1 level and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate- high- density lipoprotein (DiI-HDL) uptake were also measured in AML12 cells and HL7702 cells treated with alcohol. The control + HC diet led to increased hepatic triglyceride and cholesterol levels while alcohol + HC led no significant change. Compared with that of the control group, the SR-B1 mRNA level was elevated by 27.1% (P < 0.05), 123.8% (P < 0.001) and 343.6% (P < 0.001) in the alcohol, control + HC and alcohol + HC groups, respectively. In AML12 and HL7702 cells, SR-B1 level and DiI-HDL uptake were repressed by SR-B1 siRNA or GW9662. However, these effects were reversed through alcohol treatment. These data suggest that a moderate amount of alcohol plays a novel role in reverse cholesterol transport, mainly mediated by PPARγ and SR-B1.

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High Temperature- and High Pressure-Processed Garlic Improves Lipid Profiles in Rats Fed High Cholesterol Diets

Cited by 25 publications

References 19 publications

Interaction Between Ator and Fennel Remedies in the Treatment of Obesity in Rats

Interaction Between Ator and Fennel Remedies in the Treatment of Obesity in Rats

Lipid Profiles are Altered in Rats Fed with Different Garlic Cultivars

Chronic Moderate Alcohol Intakes Accelerate SR-B1 Mediated Reverse Cholesterol Transport

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