This study examined the high-temperature degradation behavior of two types of heat-resistant Si-Mo ductile cast iron (Fe-3.4C-3.7Si-0.4Mo and Fe-3.1C-4.5Si-1.0Mo) with particular attention paid to the mechanical properties and overall oxidation resistance. Tension and lowcycle fatigue properties were examined at 600°C and 800°C. The mechanical tests and metallographic and fractographic analyses showed that cast iron containing higher Si and Mo contents had a higher tensile strength and longer fatigue life at both temperatures than cast iron with lower levels due to the phase transformations of pearlite and carbide. The Coffin-Manson type equation was used to assess the fatigue mechanism suggesting that the higher Si-Mo alloy was stronger but less ductile than the lower Si-Mo alloy at 600°C. However, similar properties for both alloys were observed at 800°C because of softening and oxidation effects. Analysis of the isothermal oxidation behavior at those temperatures showed that mixed Fe 2 SiO 4 layers were formed and the resulting scaling kinetics was much faster for low Si-Mo containing iron. With increasing temperature, subsurface degradation such as decarburization, voids, and cracks played a significant role in the overall oxidation resistance.