High-temperature repetitive nerve stimulation in myasthenia gravis

Rutkove, Seward B.; Shefner, Jeremy M.; Wang, Annabel K.; Ronthal, Michael; Raynor, Elizabeth M.

doi:10.1002/(sici)1097-4598(199811)21:11<1414::aid-mus8>3.0.co;2-c

Cited by 21 publications

(10 citation statements)

References 17 publications

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“…The authors suggest that rise in core temperature may have worsened symptom severity in the patients, as has been seen before in studies of AT vs. RT in MS patients (52,53). While no adverse effects on the clinical status of the patients were noted, this observation should be examined further in future studies.…”

Section: Active Physical Exercise Intervention Studies In Mgsupporting

confidence: 54%

Myasthenia Gravis and Physical Exercise: A Novel Paradigm

2020

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The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheumatoid arthritis, and chronic obstructive pulmonary disease and is therefore recommended as part of the treatment regimen. Myasthenia Gravis (MG) is a chronic autoimmune disease that causes neuromuscular transmission failure resulting in abnormal fatigable skeletal muscle weakness. In spite of this fluctuating skeletal muscle weakness, it is reasonable to assume that MG patients, like healthy individuals, could benefit from some of the positive effects of physical exercise. Yet exercise-related research in the field of MG is sparse and does not provide any guidelines on how MG patients should perform physical training in order to obtain exercise's favorable effects without risking disease deterioration or more pronounced muscle fatigue. A handful of recent studies report that MG patients with mild disease activity can adhere safely to general exercise recommendations, including resistance training and aerobic training regimens, without subjective or objective disease deterioration. These findings indicate that MG patients can indeed improve their functional muscle status as a result of aerobic and high-resistance strength training. This knowledge is important in order to establish collective as well as personalized guidelines on physical exercise for MG patients. This review discusses the present knowledge on physical exercise in MG.

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Section: Active Physical Exercise Intervention Studies In Mgsupporting

confidence: 54%

Myasthenia Gravis and Physical Exercise: A Novel Paradigm

2020

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“…Though not statistically significant, the median score of the AT group increased almost twofold in all 3 questionnaires, adding further support to this notion. As heat aggravates symptom severity in MG, it is possible that the approximately 3 times greater increase in core temperature following aerobic exercise compared with resistance exercise reported in a study of MS patients may have negatively impacted the AT group. Although no adverse change in the clinical status of the AT group was observed, these patient‐reported findings give some concern and need to be monitored in future investigations.…”

Section: Discussionmentioning

confidence: 99%

Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training

et al. 2017

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“…It is important to note in these studies the comparison was made with patients who had undergone at least 15 minutes of eyelid closure. 6,7 By the very nature of the disease, rest will improve signs and symptoms but there is a rapid reduction in the time needed to elicit a positive result when ice is used and, therefore, must have some independent physiological effect on the patient's condition. The use of the ice pack test does have some drawbacks.…”

Section: Discussionmentioning

confidence: 99%