High Temperature Superconductor (HTS) based power cable is a technological marvel which can transmit bulk power over large distances without any joule heating as compared to a conventional copper cable, owing to its zero DC resistance in superconducting state. However, to maintain this superconducting state, the cable must be at a temperature below its critical temperature under self-field. Commonly used HTS material includes BSCCO (Tc = 110 K) and YBCO (Tc = 93 K) and thus, requires cryogenic liquid nitrogen (77 K) for attaining superconductivity. Further, the voltage drops across the various joints such as joint box and current leads in the termination unit must be monitored to ensure optimal operation of the cable. This demands for sophisticated instrumentation operating under extreme low cryogenic temperatures for safe operation, performance monitoring, cryogenic measurements, and control of the HTS power cable cryogenic process. This paper presents the instrumentation scheme followed for testing India’s first 6-meter HTS power cable. The instrumentation scheme involves housing of the various temperature sensors and location of voltage tapping, current measurement, cryogen flow measurements, operation of control valves, operation and measurement of high vacuum system, stray field measurement, insulation resistance measurement and dielectric measurements for cable are the important parameters for the successful operation of HTS power cable. To perform data logging NI-DAQ and LabVIEW software was used to develop in-house Supervisory Control and Data Acquisition (SCADA) system. This paper discusses intrinsic aspects of complete instrumentation and developed SCADA system for HTS power cable.