efficiency, the significance of tribology becomes evident in light of global challenges such as decreasing earth resources, i.e., fossil fuel and minerals, as well as steadily rising CO 2 emissions contributing to global warming. [4,5] In this context, friction and wear have been identified as notably contributing toward a downgraded energy efficiency, inviting the development of greener, smarter, and more sustainable tribological processes and lubricants.Since ancient times, the most straightforward approach to reduce friction and wear was to place a liquid lubricant (oil or grease) between the rubbing surfaces. This greatly reduces or eliminates the solid-solid contact, thus enabling low-friction and lowwear conditions. [6] However, after centuries of use, liquid lubricants have been pushed toward their limits due to the current trend of continuously reducing the lubricant viscosity and, therefore, the resulting film thickness. This, in turn, increases the amount of solid-solid contact, leading to harsher tribological conditions with increased friction and wear. Combined with more stringent regulations regarding the use of sulfur-and phosphorous-containing lubricant additives as well as efforts toward decarbonization to reduce CO 2 emissions and hazardous wastes, these factors propel the urgent development of alternative lubrication concepts. [4] In this context, nanomaterials used as additives in base oils or applied as solid lubricant coatings have gained notableThe large and rapidly growing family of 2D early transition metal carbides, nitrides, and carbonitrides (MXenes) raises significant interest in the materials science and chemistry of materials communities. Discovered a little more than a decade ago, MXenes have already demonstrated outstanding potential in various applications ranging from energy storage to biology and medicine. The past two years have witnessed increased experimental and theoretical efforts toward studying MXenes' mechanical and tribological properties when used as lubricant additives, reinforcement phases in composites, or solid lubricant coatings. Although research on the understanding of the friction and wear performance of MXenes under dry and lubricated conditions is still in its early stages, it has experienced rapid growth due to the excellent mechanical properties and chemical reactivities offered by MXenes that make them adaptable to being combined with other materials, thus boosting their tribological performance. In this perspective, the most promising results in the area of MXene tribology are summarized, future important problems to be pursued further are outlined, and methodological recommendations that could be useful for experts as well as newcomers to MXenes research, in particular, to the emerging area of MXene tribology, are provided.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202207757.