High terminal creatinine donors should not preclude simultaneous kidney and pancreas transplantation

Torabi, Julia; Melvin, Jeffrey; Rechnitzer, Alma; Rocca, Juan P.; Ajaimy, Maria; Lirano-Ward, Luz; Azzi, Yorg; Pynadath, Cindy; Alani, Omar; Akalin, Enver; Graham, Jay A.

doi:10.1016/j.amjsurg.2020.09.031

Cited by 5 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A donor serum creatinine level ≥2.5 mg/dl has been shown to be a risk factor for pancreas allograft failure in a multivariable model 20 . A more recent study in SPK recipients observed increased rates of kidney delayed graft function with donor acute kidney injury, but no impact on kidney and pancreas graft survival outcomes up to 12 months follow‐up 22 . Although PTx from a DCD donor may increase the risk of graft thrombosis, 23,24 excellent results can be obtained from otherwise ideal donors with short warm and cold ischemia times, particularly in SPK transplantation and with the use of extracorporeal support and normothermic perfusion devices 25,26 .…”

Section: Introductionmentioning

confidence: 99%

“…20 A more recent study in SPK recipients observed increased rates of kidney delayed graft function with donor acute kidney injury, but no impact on kidney and pancreas graft survival outcomes up to 12 months follow-up. 22 Although PTx from a DCD donor may increase the risk of graft thrombosis, 23,24 excellent results can be obtained from ) Negative perceptions created due to poor post-transplant outcomes in less optimal recipients Burden of cardiovascular disease Frailty, deconditioning, sarcopenia, malnutrition otherwise ideal donors with short warm and cold ischemia times, particularly in SPK transplantation and with the use of extracorporeal support and normothermic perfusion devices. 25,26 Donor hypertension and its duration may have an impact on long-term pancreas graft and patient survival rates.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Poor utilization of deceased donor pancreata in the United States: Time for action

Singh,

Stratta

2023

Clinical Transplantation

View full text Add to dashboard Cite

The number of solid organ pancreas transplants performed in the United States has declined over the past two decades despite improving outcomes and the known benefits associated with this procedure. Although the reasons are multifactorial, high rates of deceased donor pancreata nonrecovery and nonuse have at least in part contributed to the reduction in pancreas transplant activity. The pancreas has higher nonrecovery and nonuse rates compared to the kidney and liver because of more stringent donor selection criteria, particularly with respect to donor age and body mass index, although even marginally inferior donor pancreata likely still benefit some patients compared to alternative therapies. In this editorial, we present several donor‐, candidate‐, and center‐specific factors that are either confirmed or suspected of being associated with inferior outcomes, which contribute to high pancreas nonrecovery and nonuse rates. In addition, we have discussed several measures to increase pancreas recovery and reduce pancreas nonutilization.

show abstract