2024
DOI: 10.1101/2024.09.16.612699
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High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

Laura M Haynes,
Matthew L Holding,
Hannah DiGiovanni
et al.

Abstract: While members of large paralogous protein families share structural features, their functional niches often diverge significantly. Serine protease inhibitors (SERPINs), whose members typically function as covalent inhibitors of serine proteases, are one such family. Plasminogen activator inhibitor-1 (PAI-1) is a prototypic SERPIN, which canonically inhibits tissue- and urokinase-type plasminogen activators (tPA and uPA) to regulate fibrinolysis. PAI 1 has been shown to also inhibit other serine proteases, incl… Show more

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