High-throughput analysis of tetracycline antibiotics and their epimers in liquid hog manure using Ultra Performance Liquid Chromatography with UV detection

Tylová, Tereza; Olšovská, Jana; Novák, Petr; Flieger, Miroslav

doi:10.1016/j.chemosphere.2009.11.020

Cited by 44 publications

(23 citation statements)

References 17 publications

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“…Besides medication, fish was supposed to reabsorb the antibiotics in manure, water, lower trophic population and sediment through food consumption. Previous researches reported that a large percentage of antibiotics were excreted in manure and accumulated in the aquatic environment because they were not fully metabolized in the animal's body (Tao et al 2010;Tylova et al 2010). Average levels in fish tissues from Dapeng'ao were higher than those from Hailing Island, which conciliated with the results obtained from the sediment samples.…”

Section: Fqs In Fish Tissue Samplessupporting

confidence: 90%

Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China

Wang

Nie

et al. 2011

Environ Geochem Health

118

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Concentrations and distributions of selected fluoroquinolones (norfloxacin, ciprofloxacin and enrofloxacin) in water, sediments and nine kinds of fish species collected from 6 sites in two marine aquaculture regions of the Pearl River Delta, China, were analyzed by using high-performance liquid chromatography with fluorescence detector (HPLC). The results showed that the concentrations of ciprofloxacin and enrofloxacin were below the limits of quantification (LOQ) in all water samples except for norfloxacin. Norfloxacin and ciprofloxacin concentrations ranged from 1.88 to 11.20 ng g(-1) dry wt, 0.76-2.42 ng g(-1) dry wt in sediments collected from the Dapeng'ao region (sites 1-3) and ranged from 2.31 to 4.75 ng g(-1) dry wt, 1.26-1.76 ng g(-1) dry wt in sediments collected from the Hailing Island region (sites 4-6), respectively. However, no enrofloxacin was found in all sediment samples. The three fluoroquinolones (FQs) were detected in all fish samples, and the concentrations were higher in liver tissues than those in muscle tissues. The levels of norfloxacin were higher than ciprofloxacin and enrofloxacin in both liver and muscle tissues. Among the nine marine fish species, Siganus fuscescens from Hailing Island had a significantly high level of norfloxacin in liver tissue (254.58 ng g(-1) wet wt), followed by Sparus macrocephalus (133.15 ng g(-1) wet wt) from Dapeng'ao, and the lowest value was Lutianus argentimaculatus (5.18 ng g(-1) wet wt) from Hailing Island. The obtained results of FQs in present study do not represent a risk to the human health in Guangdong coastal area, based on the maximum residue limits (MRLs) established by Chinese Government and the acceptable daily intake (ADI) recommended by the Food and Agriculture Organization and World Health Organization (FAO/WHO).

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Section: Fqs In Fish Tissue Samplessupporting

confidence: 90%

Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China

Wang

Nie

et al. 2011

Environ Geochem Health

118

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“…Satisfactory recoveries were observed for the parent compounds such as OTC, CTC and TC, but recoveries of degradation products were relatively low. The recoveries were usually in the same range as for other published methods (Hamscher et al, 2002;Martínez-Carballo et al, 2007;Tylová et al, 2010). The antibiotic concentrations were not corrected for recoveries.…”

Section: Sample Analysismentioning

confidence: 54%

“…Hamscher et al (2002) reported that liquid manure contained 100 μg/kg CTC, which was comparable to the samples from Jiaxing. Tylová et al (2010) detected CTC in liquid hog manure at a concentration of 5880 μg/kg. In China, the detection frequency of OTC or CTC was generally high.…”

Section: Occurrence Of Tetracyclines In Manurementioning

confidence: 99%

Fate of tetracyclines in swine manure of three selected swine farms in China

Qiao

Chen²,

et al. 2012

Journal of Environmental Sciences

114

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Veterinary antibiotics can enter the environment due to the common practice of land application of manure from treated animals. The environmental fate of tetracyclines in swine manure after composting and field application remains largely unknown. This study analyzed the concentrations of tetracyclines in manure, manure-based compost and compost amended soil in selected swine farms from Beijing, Jiaxing and Putian, China to determine the dilution effects of antibiotics when released into the soil environment. The results demonstrate that residues of antibiotics were detected in all samples and chlortetracycline as well as its degradation products should be regarded critically concerning their potential ecotoxicity. Application of manure-based compost to soil could reduce the possible risk posed by antibiotic contamination, but the trigger value of 100 μg/kg was still exceeded in soil samples (776.1 μg/kg dw) from Putian City after application of compost. Field studies such as the present one can help to improve the routine administration of antibiotic-containing composted manure.

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“…The later one is a trifunctionally bonded alkyl column, which can impact the retention, selectivity and sensitivity of ionizable compounds, thus has been used to separate PFAAs extensively [7,30,31,33]. The former one contains an embedded-polar group that combines the hydrophobicity of a straight-chain-alkyl ligand (C18) with the hydrophilicity of an embedded polar group (carbamate), which improves the retention of and peak shape of polyhydric substances [40,41]. Two ACQUITY UPLC BEH Shield RP18 columns with different lengths (50 mm × 2.1 mm and 150 mm × 2.1 mm) were compared and it was found that the longer column (150 mm × 2.1 mm) had both higher separation efficiency and better peak shape.…”

Section: Chromatograms Of Ftohs and Poly-and Perfluorinated Acidsmentioning

confidence: 99%

Determination of fluorotelomer alcohols and their degradation products in biosolids-amended soils and plants using ultra-high performance liquid chromatography tandem mass spectrometry

Zhang

Wen

et al. 2015

Journal of Chromatography A

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a b s t r a c tDegradation of fluorotelomer alcohols (FTOHs) was recognized as an additional source of perfluorocarboxylic acids (PFCAs). Quantification of FTOHs and their degradation products can help shed light on the sources and fates of PFCAs in the environment. In this study, an analytical method was developed for the determination of 6:2 and 8:2 FTOHs, and their degradation products of poly-and perfluorinated acids, including fluorotelomer saturated and unsaturated carboxylic acids (FTCAs and FTUCAs), secondary polyfluorinated alcohols and PFCAs in biosolids-amended soils and plants using ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The extract efficiencies of different methods including ethyl acetate and methanol (MeOH) for FTOHs and acetonitrile, MeOH, methyl tertbutyl ether (MTBE), NaOH-MeOH and NaOH-MTBE for poly-and perfluorinated acids were tested. The results showed that 6:2 and 8:2 FTOHs and their degradation products could be simultaneously and satisfactorily extracted by MeOH, cleaned up by Envi-Carb graphitized carbon and solid phase extraction, respectively, and determined by UPLC-MS/MS separately. NaOH in the extractant caused the conversion of 6:2 FTCA and 8:2 FTCA into the corresponding FTUCAs. The selected methods have matrix recoveries ranged from 52% to 102%, and detection limits of 0.01-0.46 ng/g dry weight for FTOHs and their degradation products in soil and plant. The optimized method was applied successfully to quantify FTOHs and their degradation products in two biosolids-amended soils and plants. The total concentrations of FTOHs in the soils were 44.1 ± 5.8 and 82.6 ± 7.1 ng/g, and in plants tissues 3.58 ± 0.25 and 8.33 ± 0.66 ng/g. The total concentrations of poly-and perfluorinated acids in the soils were 168.0 ± 13.2 and 349.6 ± 11.2 ng/g, and in plants tissues 78.0 ± 6.4 and 75.5 ± 5.3 ng/g.

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High-throughput analysis of tetracycline antibiotics and their epimers in liquid hog manure using Ultra Performance Liquid Chromatography with UV detection

Cited by 44 publications

References 17 publications

Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China

Residues of fluoroquinolones in marine aquaculture environment of the Pearl River Delta, South China

Fate of tetracyclines in swine manure of three selected swine farms in China

Determination of fluorotelomer alcohols and their degradation products in biosolids-amended soils and plants using ultra-high performance liquid chromatography tandem mass spectrometry

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