High-throughput assays on the chip based on metal nano-cluster resonance transducers

Mayer, Christian; Stich, Norbert; Palkovits, Roland; Bauer, Georg; Pittner, Fritz; Schalkhammer, Thomas G. M.

doi:10.1016/s0731-7085(00)00545-8

Cited by 16 publications

(10 citation statements)

References 11 publications

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“…High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell HMGB1 overexpression has been reported in a variety of human cancers, including melanoma, 11 pancreatic cancer, prostate cancer, 12 colorectal cancer 13 and breast cancer. 14 HMGB2 have been significantly upregulated in glioblastoma tissues, compared with a low level of expression in normal human brain tissues.…”

Section: Introductionmentioning

confidence: 99%

High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell

Shin

Kim

et al. 2012

Cancer Biology & Therapy

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Section: Introductionmentioning

confidence: 99%

High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell

Shin

Kim

et al. 2012

Cancer Biology & Therapy

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“…Hofman et al developed an efficient sample delivery system and tested it with immunoassays on planar waveguides [191]. Mayer et al reported a novel transduction mechanism in which conformational changes of proteins can be monitored by surface-enhanced metal nanocluster resonance [192,193]. Microarrays of SPR elements integrated with an interferometer were developed leading to much lower sensitivities than those obtained with conventional SPR sensors and with a resolution in the micrometer range [194].…”

Section: Microbiosensors and Nanobiosensorsmentioning

confidence: 99%

Biosensors for environmental pollutants and food contaminants

Baeumner

2003

Analytical and Bioanalytical Chemistry

216

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This review article provides an overview of the most recent literature on biosensors for environmental pollutants and food contaminants. Due to the large number of publications, only papers published between 2000 and January 2003 were considered. Also, while not all of the published literature could be reviewed here, over 200 references are cited to provide a good overview of research undertaken in the last two years. Older publications are covered by a number of earlier review articles. This article provides an introduction into the field including specific consideration of the application areas, describes the typical biosensor assay format used, and is subsequently structured according to the biorecognition elements used (i.e., nucleic acids, enzymes, whole cells, tissue and whole organisms, antibodies and receptors, and biomimetic materials). In addition, a section on microbiosensing systems is provided. Since only very few microbiosensors with applications in environmental and food systems have been published, enabling technology is also covered in this article.

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“…Spherical metal clusters enhance absorption approximately 8 fold at the peak maximum, relative absorption enhancement is above 100 fold. Below a wavelength of 600nm the enhancement is independent of the way of application of the cluster layers, but depends strongly on the attachment of clusters under given conditions [25][26][27][28][29][30] . At any wavelength above 600nm the optical properties of the clusters become dependent on the manufacturing process, due to differences in asymmetry and the degree of crystallinity of the nano-structure.…”

Section: Sea-chipsmentioning

confidence: 99%

Cluster optical coding: from biochips to counterfeit security

Haglmueller¹,

Alguel²,

Mayer³

et al. 2004

SPIE Proceedings

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Spatially tuned resonant nano-clusters allow high local field enhancement when excited by electromagnetic radiation. A number of phenomena has been described and subsequently applied for the construction of novel nano-and bionano-devices. Easy to manufacture, cost efficient and high throughput transducers using metal cluster resonance technology are based on surface-enhancement of metal cluster light absorption (SEA). The optical phenomenon driving SEA in metal cluster films is the so-called anomalous absorption. At a well defined nanometric distance of a cluster to a mirror the reflected electromagnetic field has the same phase at the position of the absorbing cluster as the incident fields. This feedback mechanism strongly enhances the effective cluster absorption coefficient. Such a system is characterized by a narrow reflection minimum. Based on this SEA-phenomenon (licensed to and further developed by november AG) a number of commercial products has been constructed. Brandsealing R uses the patented SEA cluster technology to produce optical codings. Cluster SEA thin film systems show a characteristic color-flip effect and are extremely robust. Both properties are vital for application as a unique security feature. The specific narrow band multi-resonance of the cluster layers allow easy authentication of the optical code. This can be achieved with a hand-held reader being developed by november AG and Siemens AG. SEA features are machine-readable which makes them superior to comparable technologies. Cluster labels are available in two formats: as a label for tamper-proof product packaging, and as a direct label, where label and logo are permanently applied directly and unremovable to the product surface. Together with Infineon Technologies and HUECK FOLIEN, the SEA technology is currently developed as a direct label for e.g. SmartCards.

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High-throughput assays on the chip based on metal nano-cluster resonance transducers

Cited by 16 publications

References 11 publications

High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell

High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell

Biosensors for environmental pollutants and food contaminants

Cluster optical coding: from biochips to counterfeit security

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