2020
DOI: 10.3390/ijms21176370
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High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75

Abstract: Recently an increasing number of new adenovirus types associated with type-dependent pathogenicity have been identified. However, identification of these clinical isolates represents the very first step to characterize novel pathogens. For deeper analyses, these adenoviruses need to be further characterized in basic virology experiments or they could be applied in translational research. To achieve this goal, it is essential to get genetic access and to enable genetic modification of these novel adenovirus gen… Show more

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Cited by 13 publications
(20 citation statements)
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“…Recently, three additional Ads including Ad 70, 73, and 74 have been isolated from fecal samples and successfully tagged with a green-fluorescent protein (GFP) and nano- luciferase [ 3 ]. First, we hypothesized whether the transduction efficiency in NAEPCs can be dose-dependent.…”
Section: Resultsmentioning
confidence: 99%
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“…Recently, three additional Ads including Ad 70, 73, and 74 have been isolated from fecal samples and successfully tagged with a green-fluorescent protein (GFP) and nano- luciferase [ 3 ]. First, we hypothesized whether the transduction efficiency in NAEPCs can be dose-dependent.…”
Section: Resultsmentioning
confidence: 99%
“…For host cell infection, they utilize different cell surface molecules, including the coxsackie and adenovirus receptor (CAR), cluster of differentiation (CD46), desmoglein-2, GD1a ganglioside and sialic acid residues for virus entry usually followed by integrin-mediated virus internalization, which explains the broad tissue tropism of Ads [ 2 ]. Currently, the known human Ads are subdivided into seven species (A–G) with different hemagglutination properties, oncogenicity, DNA homology and genomic organization [ 3 , 4 ]. Ads are used in gene therapy to treat genetic disorders such as cystic fibrosis, as vector for vaccination studies or in virotherapy to treat cancer [ 5 , 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
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