High-throughput fabrication of silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) nanofibrous scaffolds for skin tissue engineering

Yin, Jing; Fang, Yue; Xu, Lan; Ahmed, Adnan

doi:10.1016/j.ijbiomac.2021.05.026

Cited by 34 publications

(21 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 A). The HPMC nanofibers are hypoallergenic and have excellent biocompatibility and skin adhesion 24 , 25 , while PVA is an excellent matrix for storing and releasing drug molecules 26 , 27 . The two HPMC layers are 5.2 μm thick and consist of 110 ± 20 nm nanofibers to provide structural support for the 30.5 mm thick electrospun PVA (200 ± 40) nm.…”

Section: Resultsmentioning

confidence: 99%

A new versatile x–y–z electrospinning equipment for nanofiber synthesis in both far and near field

Calzado-Delgado

Guerrero‐Pérez

Yeung

2022

Sci Rep

View full text Add to dashboard Cite

This work describes a versatile electrospinning equipment with rapid, independent, and precise x–y–z movements for large-area depositions of electrospun fibers, direct writing or assembly of fibers into sub-millimeter and micron-sized patterns, and printing of 3D micro- and nanostructures. Its versatility is demonstrated thought the preparation of multilayered functional nanofibers for wound healing, nanofiber mesh for particle filtration, high-aspect ratio printed lines, and freestanding aligned nanofibers.

show abstract

Section: Resultsmentioning

confidence: 99%

A new versatile x–y–z electrospinning equipment for nanofiber synthesis in both far and near field

Calzado-Delgado

Guerrero‐Pérez

Yeung

2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Despite the above advantages of SF for TE, there are still some disadvantages cannot be ignored, including poor cell adherence and growth, low biodegradability ( Cao and Wang, 2009 ). To cope with the drawbacks of not sufficient cells attach and growth, SF is often combined with other polymers to fabricate SF-based biomaterials with enhanced biological behavior ( Cai et al, 2017 ; Sarıkaya and Gümüşderelioğlu, 2021 ; Yin et al, 2021 ). Some literatures also reported the strategies to tune the degradation rate of SF.…”

Section: Strategies Involving Scaffolds For Tendon Tissue Engineeringmentioning

confidence: 99%

Recent advances in tendon tissue engineering strategy

Ning

Li²,

Gao³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Tendon injuries often result in significant pain and disability and impose severe clinical and financial burdens on our society. Despite considerable achievements in the field of regenerative medicine in the past several decades, effective treatments remain a challenge due to the limited natural healing capacity of tendons caused by poor cell density and vascularization. The development of tissue engineering has provided more promising results in regenerating tendon-like tissues with compositional, structural and functional characteristics comparable to those of native tendon tissues. Tissue engineering is the discipline of regenerative medicine that aims to restore the physiological functions of tissues by using a combination of cells and materials, as well as suitable biochemical and physicochemical factors. In this review, following a discussion of tendon structure, injury and healing, we aim to elucidate the current strategies (biomaterials, scaffold fabrication techniques, cells, biological adjuncts, mechanical loading and bioreactors, and the role of macrophage polarization in tendon regeneration), challenges and future directions in the field of tendon tissue engineering.

show abstract

“…In contrast, low values can generate an accumulation of exudate that can extend the wound healing process and promote infections. 80 The water vapor permeation (WVP) analysis of films prepared with PVA/SA and melanin nanoparticles indicated decreased WVP value. 72 The authors attributed the increase in the water vapor barrier properties to nanoparticles reducing the surface uniformity of the films, causing the water molecules to move randomly along the polymer chains and hindering passage through the matrix.…”

Section: Water Vapor Permeation and Water Vapor Transmission Ratementioning

confidence: 99%

“…Ideally, WVTR values close to human skin (2000–2500 g/m 2 /24 h) are desired, while high values of WVTR can cause the wounds to dry too quickly. In contrast, low values can generate an accumulation of exudate that can extend the wound healing process and promote infections 80 …”

Section: Alginate and Pva: Physicochemical Characterization And Biome...mentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

View full text Add to dashboard Cite

The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

show abstract

High-throughput fabrication of silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) nanofibrous scaffolds for skin tissue engineering

Cited by 34 publications

References 63 publications

A new versatile x–y–z electrospinning equipment for nanofiber synthesis in both far and near field

A new versatile x–y–z electrospinning equipment for nanofiber synthesis in both far and near field

Recent advances in tendon tissue engineering strategy

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Contact Info

Product

Resources

About