High-throughput liquid chromatography mass-spectrometry-driven lipidomics discover metabolic biomarkers and pathways as promising targets to reveal the therapeutic effects of the Shenqi pill

Abstract

Lipidomics, a branch of metabonomics, could provide a powerful technique for discovery of lipid molecules to reveal disease status and drug efficacy.

High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis

“…Functional metabolomics as a promising method could be used for the discovery of biomarkers to reveal the metabolic effect and potential targets of natural products ( Wang et al, 2016 ; Qiu et al, 2017 ; Sun et al, 2018 ; Zhang et al, 2018 ; Wang et al, 2019 ; Zhang et al, 2019 ; Li et al, 2020 ; Qiu et al, 2020 ). The citric acid cycle is a process that release energy by oxidizing acetyl-Co A (Acetyl coenzyme A, acetyl-Co A) in all aerobic organisms.…”

Using machine learning approaches for multi-omics data analysis: A review

“…Liquid Chromatography -Mass Spectrometry (Li et al, 2020), High-performance Liquid Chromatography -Mass Spectrometry (Knittelfelder et al, 2014) and Direct-Infusion/Shotgun -Mass Spectrometry (Köfeler et al, 2012).…”

A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry

“…18 In 2003, the concept of lipidomics was proposed by researchers, which is an area of the metabolomics research eld for probing the species and biological function of lipid molecules on a largescale and complete molecular level. 19 Research on the identication and quantication of lipids involves fatty acids, glycerophospholipids, glycerolipids, sphingolipids, sterols, saccharolipids, prenol lipids and others in cells, tissues, and biological uids. It methodically expresses the small changes in the composition and expression of lipids triggered by stimuli in vivo and vitro, which offers a novel opportunity for comprehending the functional activity of various lipids in disease.…”