2024
DOI: 10.1002/dta.3778
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High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Maria Fernanda Cifuentes Girard,
Patrick Knight,
Gérard Hopfgartner

Abstract: The use of differential mobility spectrometry at low pressure coupled to liquid chromatography‐mass spectrometry (LC‐vDMS‐MS) was investigated for the analysis of 13 drugs of abuse (DoA) including the following: cocaine, ecgonine methyl ester, cocaethylene, benzoylecgonine, norcocaine, tramadol, isomeric pairs of metabolites; O‐desmethyl‐cis‐tramadol and N‐desmethyl‐cis‐tramadol, and cannabinoids: Δ9‐tetrahydrocannabinol, Δ9‐tetrahydrocannabidiol, 11‐hydroxy‐Δ9‐tetrahydrocannabinol, 11‐nor‐9carboxy‐Δ9‐tetrahyd… Show more

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