High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites
Taher Uddin,
Jing Xia,
Yong Fu
et al.
Abstract:Toxoplasma gondiicauses widespread chronic infections that are not cured by current treatments due to inability to affect semi-dormant bradyzoite stages within tissue cysts. To identify compounds to eliminate chronic infection, we developed a HTS using a recently characterized strain ofT. gondiithat undergoes efficient conversion to bradyzoites in intro. Stage-specific expression of luciferase was used to selectively monitor growth inhibition of bradyzoites by the Library of Pharmacological Active Compounds, c… Show more
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