2021
DOI: 10.1063/5.0057204
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High-throughput screening of nanoparticles in drug delivery

Abstract: The use of pharmacologically active compounds to manage and treat diseases is of utmost relevance in clinical practice. It is well recognized that spatial-temporal control over the delivery of these biomolecules will greatly impact their pharmacokinetic profile and ultimately their therapeutic effect. Nanoparticles (NPs) prepared from different materials have been tested successfully in the clinic for the delivery of several biomolecules including non-coding RNAs (siRNA and miRNA) and mRNAs. Indeed, the recent… Show more

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Cited by 14 publications
(7 citation statements)
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“…In order to evaluate the connections between various physical and chemical factors and cytotoxicity, for instance, high-throughput screening technology has been developed. Nanoparticle (NP) and nanobiological system (NBS) interactions can be understood and predicted with the help of structure-based computational molecular modeling [ 189 ].…”
Section: Metal Nanoparticle Potential Cytotoxicitymentioning
confidence: 99%
“…In order to evaluate the connections between various physical and chemical factors and cytotoxicity, for instance, high-throughput screening technology has been developed. Nanoparticle (NP) and nanobiological system (NBS) interactions can be understood and predicted with the help of structure-based computational molecular modeling [ 189 ].…”
Section: Metal Nanoparticle Potential Cytotoxicitymentioning
confidence: 99%
“…Targeted delivery allows for reduction of potential side effects and increased payload delivery. 2 , 3 Nanoparticles (NPs) can achieve organ/cell specificity (through both passive and active targeting methods), payload release control, and solubility improvement. 3 Lipid nanoparticles (LNPs) in particular have emerged as a promising delivery vehicle for mRNA due to their ability to protect the mRNA and achieve targeting specificity.…”
Section: Main Textmentioning
confidence: 99%
“…This possibility will also open great opportunities in nanomedicine research, a field pioneered by Prof. Langer about 20 years ago ( 47 ), which has never been really developed. MTS or HTS assays for NPs will have a tremendous benefit for nanomedicine, especially now that nanoparticle-based mRNA therapeutics have been well recognized in clinics ( 48 , 49 ). Thus, the use of 3D culture technologies, MCTSs in primis , in cancer nanomedicine MTS/HTS is a compelling unmet need.…”
Section: Mctss In Nanomedicine Researchmentioning
confidence: 99%